A 56-year-old patient was admitted in our institution for an acute ischemic stroke due to the occlusion of the right middle cerebral artery. Angio-CT scan performed upon admission showed lesions suggestive of COVID-19, which was confirmed by specific SARS-CoV-2 polymerase chain reaction (PCR). The next day, the patient developed abdominal pain and vomiting. CT scan was performed. It demonstrated a free-floating thrombus of the aortic arch (Fig. 1, panel a) associated with an occlusion of the superior mesenteric artery (Fig. 1, panel b). There was no sign of aortic atherosclerosis. Absence of enhancement of part of the small bowel wall was also noted (Fig. 1, panel c). The patient underwent endovascular thrombectomy and a laparotomy with the resection of two meters of the small bowel.