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Virchows Archiv

Issue 4/2018

Content (21 Articles)

Review and Perspectives

Eighth Edition of the UICC Classification of Malignant Tumours: an overview of the changes in the pathological TNM classification criteria—What has changed and why?

Luca Bertero, Federica Massa, Jasna Metovic, Roberto Zanetti, Isabella Castellano, Umberto Ricardi, Mauro Papotti, Paola Cassoni

Open Access Review and Perspectives

Dilemmas for the pathologist in the oncologic assessment of pancreatoduodenectomy specimens

Eline Soer, Lodewijk Brosens, Marc van de Vijver, Frederike Dijk, Marie-Louise van Velthuysen, Arantza Farina-Sarasqueta, Hans Morreau, Johan Offerhaus, Lianne Koens, Joanne Verheij

Open Access Original Article

Multicenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics

B. Hirsch, V. Endris, S. Lassmann, W. Weichert, N. Pfarr, P. Schirmacher, V. Kovaleva, M. Werner, I. Bonzheim, F. Fend, J. Sperveslage, K. Kaulich, A. Zacher, G. Reifenberger, K. Köhrer, S. Stepanow, S. Lerke, T. Mayr, D. E. Aust, G. Baretton, S. Weidner, A. Jung, T. Kirchner, M. L. Hansmann, L. Burbat, E. von der Wall, M. Dietel, M. Hummel

Original Article

Most high-grade neuroendocrine tumours of the lung are likely to secondarily develop from pre-existing carcinoids: innovative findings skipping the current pathogenesis paradigm

Giuseppe Pelosi, Fabrizio Bianchi, Elisa Dama, Michele Simbolo, Andrea Mafficini, Angelica Sonzogni, Sara Pilotto, Sergio Harari, Mauro Papotti, Marco Volante, Gabriella Fontanini, Luca Mastracci, Adriana Albini, Emilio Bria, Fiorella Calabrese, Aldo Scarpa

Original Article

Population-level effect of molecular testing and targeted therapy in patients with advanced pulmonary adenocarcinoma: a prospective cohort study

Christine Schwegler, Dinu Kaufmann, David Pfeiffer, Stefan Aebi, Joachim Diebold, Oliver Gautschi

Open Access Original Article

Immune cell landscape in therapy-naïve squamous cell and adenocarcinomas of the lung

Luka Brcic, Stefanie Stanzer, Dagmar Krenbek, Ulrike Gruber-Moesenbacher, Gudrun Absenger, Franz Quehenberger, Arschang Valipour, Joerg Lindenmann, Herbert Stoeger, Mohamed Al Effah, Melanie Fediuk, Marija Balic, Helmut H. Popper

Original Article

Handling and reporting of transperineal template prostate biopsy in Europe: a web-based survey by the European Network of Uropathology (ENUP)

Solene-Florence Kammerer-Jacquet, Eva Compérat, Lars Egevad, Ondra Hes, Jon Oxley, Murali Varma, Glen Kristiansen, Daniel M. Berney

Original Article

Snail immunohistochemical overexpression correlates to recurrence risk in non-muscle invasive bladder cancer: results from a longitudinal cohort study

Raffaella Santi, Tommaso Cai, Stefania Nobili, Ilaria Camilla Galli, Andrea Amorosi, Eva Comperat, Gabriella Nesi

Original Article

Size and heterologous elements predict metastases in malignant phyllodes tumours of the breast

Valerie Cui Yun Koh, Aye Aye Thike, Nur Diyana Md Nasir, George Wai Cheong Yip, Boon Huat Bay, Puay Hoon Tan

Original Article

Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma

Judicaël Hotton, Mikaël Agopiantz, Agnès Leroux, Claire Charra-Brunaud, Béatrice Marie, Hélène Busby-Venner, Olivier Morel, Jean-Louis Guéant, Jean-Michel Vignaud, Shyue-Fang Battaglia-Hsu, Guillaume Gauchotte

Original Article

CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8+/Foxp3+ T cells

Hiroyuki Abe, Ruri Saito, Takashi Ichimura, Akiko Iwasaki, Sho Yamazawa, Aya Shinozaki-Ushiku, Teppei Morikawa, Tetsuo Ushiku, Hiroharu Yamashita, Yasuyuki Seto, Masashi Fukayama

Original Article

High immune cell score predicts improved survival in pancreatic cancer

Kyösti Tahkola, Jukka-Pekka Mecklin, Erkki-Ville Wirta, Maarit Ahtiainen, Olli Helminen, Jan Böhm, Ilmo Kellokumpu

Original Article

Histological activity score on baseline liver biopsy can predict non-response to steroids in patients with severe alcoholic hepatitis

Saggere Muralikrishna Shasthry, Archana Rastogi, Chhagan Bihari, Rajan Vijayaraghavan, Vinod Arora, Manoj Kumar Sharma, Shiv Kumar Sarin

Brief Report

CTNNB1-mutated melanocytic lesions with DPN like features: a distinct subtype of melanocytic tumors? A report of two cases

B. T. Teunissen, G. J. Knuiman, A. Eijkelenboom, C. A. P. Wauters, S. Wouda, W. A. M. Blokx