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Archives of Virology
Published in: Archives of Virology 7/2010

01-07-2010 | Brief Review

Viral interaction with molecular chaperones: role in regulating viral infection

Authors: Allen Xiao, Jerry Wong, Honglin Luo

Published in: Archives of Virology | Issue 7/2010

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Abstract

As essential effectors in protein quality control, molecular chaperones serve as the primary checkpoint to assist proper protein folding and prevent misfolded proteins from denaturation and aggregation. In addition, chaperones can function to direct terminally misfolded proteins to the proteolytic system for degradation. Viruses rely on host cell machineries for productive infection. Like for many other processes, various viruses have been shown to evolve mechanisms to utilize or subvert the host protein quality control machinery to support the completion of their life cycle. Furthermore, recent studies suggest that some viruses encode for their own chaperone-like proteins to enhance their infectivity. This review summarizes the current understanding of the interplay between molecular chaperones and viral proteins, highlights the chaperone activities of a number of viral proteins, and discusses potential antiviral therapeutic strategies targeting the virus-chaperone interactions.
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Metadata
Title
Viral interaction with molecular chaperones: role in regulating viral infection
Authors
Allen Xiao
Jerry Wong
Honglin Luo
Publication date
01-07-2010
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 7/2010
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-010-0691-3

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