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01-09-2013 | Case Report

Venovenous ECMO as a bridge to lung transplant and a protective strategy for subsequent primary graft dysfunction

Authors: Don Hayes Jr., Mark Galantowicz, Andrew R. Yates, Thomas J. Preston, Heidi M. Mansour, Patrick I. McConnell

Published in: Journal of Artificial Organs | Issue 3/2013

Abstract

Extracorporeal membrane oxygenation (ECMO) is an established therapy for primary graft dysfunction (PGD) in adults after lung transplant, while venovenous (VV) ECMO is an evolving therapy that can bridge patients to lung transplantation. This report describes a case of relatively quick improvement of grade 3 PGD, based on the PaO₂/FIO₂ (P/F) ratio, in a 17-year-old patient with cystic fibrosis who was bridged to lung transplantation with ambulatory VV ECMO and then received support with VV ECMO as a protective strategy during the initial phases of PGD after lung transplantation.

Garcia JP, Iacono A, Kon ZN, Griffith BP. Ambulatory extracorporeal membrane oxygenation: a new approach for bridge-to-lung transplantation. J Thorac Cardiovasc Surg. 2010;139:e137–9.PubMedCrossRef

Mangi AA, Mason DP, Yun JJ, Murthy SC, Pettersson GB. Bridge to lung transplantation using short-term ambulatory extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg. 2010;140:713–5.PubMedCrossRef

Turner DA, Cheifetz IM, Rehder KJ, Williford WL, Bonadonna D, Banuelos SJ, Peterson-Carmichael S, Lin SS, Davis RD, Zaas D. Active rehabilitation and physical therapy during extracorporeal membrane oxygenation while awaiting lung transplantation: a practical approach. Crit Care Med. 2011;39:2593–8.PubMed

Hayes D Jr, Kukreja J, Tobias JD, Ballard HO, Hoopes CW. Ambulatory venovenous extracorporeal respiratory support as a bridge for cystic fibrosis patients to emergent lung transplantation. J Cyst Fibros. 2012;11:40–5.PubMedCrossRef

Fischer S, Simon AR, Welte T, Hoeper MM, Meyer A, Tessmann R, Gohrbandt B, Gottlieb J, Haverich A, Strueber M. Bridge to lung transplantation with the novel pumpless interventional lung assist device NovaLung. J Thorac Cardiovasc Surg. 2006;131:719–23.PubMedCrossRef

Arcasoy SM, Fisher A, Hachem RR, Scavuzzo M, Ware LB, ISHLT Working Group on Primary Lung Graft Dysfunction. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part V: predictors and outcomes. J Heart Lung Transplant. 2005;24:1483–8.PubMedCrossRef

Christie JD, Carby M, Bag R, Corris P, Hertz M, Weill D, ISHLT Working Group on Primary Lung Graft Dysfunction. Report of the ISHLT working group on primary lung graft dysfunction part ii: definition. A consensus statement of the international society for heart and lung transplantation. J Heart Lung Transplant. 2005;24:1454–9.PubMedCrossRef

Christie JD, Bavaria JE, Palevsky HI, Litzky L, Blumenthal NP, Kaiser LR, Kotloff RM. Primary graft failure following lung transplantation. Chest. 1998;114:51–60.PubMedCrossRef

King RC, Binns OA, Rodriguez F, Kanithanon RC, Daniel TM, Spotnitz WD, Tribble CG, Kron IL. Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation. Ann Thorac Surg. 2000;69:1681–5.PubMedCrossRef

10.

Christie JD, Kotloff RM, Pochettino A, Arcasoy SM, Rosengard BR, Landis JR, Kimmel SE. Clinical risk factors for primary graft failure following lung transplantation. Chest. 2003;124:1232–41.PubMedCrossRef

11.

Christie JD, Sager JS, Kimmel SE, Ahya VN, Gaughan C, Blumenthal NP, Kotloff RM. Impact of primary graft failure on outcomes following lung transplantation. Chest. 2005;127:161–5.PubMedCrossRef

12.

Fiser SM, Kron IL, McLendon Long S, Kaza AK, Kern JA, Tribble CG. Early intervention after severe oxygenation index elevation improves survival following lung transplantation. J Heart Lung Transplant. 2001;20:631–6.PubMedCrossRef

13.

Smits JM, Mertens BJ, Van Houwelingen HC, Haverich A, Persijn GG, Laufer G. Predictors of lung transplant survival in eurotransplant. Am J Transplant. 2003;3:1400–6.PubMedCrossRef

14.

Wigfield CH, Lindsey JD, Steffens TG, Edwards NM, Love RB. Early institution of extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation improves outcome. J Heart Lung Transplant. 2007;26:331–8.PubMedCrossRef

15.

Fischer S, Bohn D, Rycus P, Pierre AF, de Perrot M, Waddell TK, Keshavjee S. Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: analysis of the Extracorporeal Life Support Organization (ELSO) registry. J Heart Lung Transplant. 2007;26:472–7.PubMedCrossRef

16.

Hartwig MG, Walczak R, Lin SS, Davis RD. Improved survival but marginal allograft function in patients treated with extracorporeal membrane oxygenation after lung transplantation. Ann Thorac Surg. 2012;93:366–71.PubMedCrossRef

Title: Venovenous ECMO as a bridge to lung transplant and a protective strategy for subsequent primary graft dysfunction
Authors: Don Hayes Jr.
Mark Galantowicz
Andrew R. Yates
Thomas J. Preston
Heidi M. Mansour
Patrick I. McConnell
Publication date: 01-09-2013
Publisher: Springer Japan
Published in: Journal of Artificial Organs / Issue 3/2013
Print ISSN: 1434-7229
Electronic ISSN: 1619-0904
DOI: https://doi.org/10.1007/s10047-013-0699-z

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Venovenous ECMO as a bridge to lung transplant and a protective strategy for subsequent primary graft dysfunction

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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