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01-09-2021 | Venous Thrombosis | Original Article

Incidence and risk factors of venous thromboembolism after percutaneous nephrolithotomy: a single-center experience

Authors: Huimin Zeng, Meng Gao, Jinbo Chen, Yu Cui, Fang Huang, Feng Zeng, Zhongqing Yang, Yang Li, Zhiyong Chen, Zewu Zhu, Hequn Chen

Published in: World Journal of Urology | Issue 9/2021

Abstract

Purpose

To determine the incidence and risk factors of the venous thromboembolism (VTE) in patients undergoing percutaneous nephrolithotomy (PCNL).

Methods

We retrospectively reviewed the records of 896 consecutive cases receiving PCNL between July 2018 and August 2020 in our institution. Univariate analysis was performed to identify the risk factors of VTE, and multivariate logistic regression analysis was further performed to determine the independent risk factors. Furthermore, the corresponding nomogram was conducted to establish a predicted model for VTE.

Results

The overall incidence of VTE was 2.8%. The multivariate logistic regression analysis showed that discontinued anticoagulant or antiplatelet therapies (OR 4.505, 95% CI 1.410–14.401), increased postoperative 12-h d-dimer (OR 11.162, 95% CI 2.370–52.574), hydronephrosis (OR 3.303, 95% CI 1.303–8.375), higher Caprini risk assessment model (RAM) score (OR 3.233, 95% CI 1.207–8.659) and postoperative sepsis or septic shock (OR 3.784, 95% CI 1.163–12.306) were independent risk factors of VTE following PCNL. Moreover, the area under the curve of postoperative 12-h d-dimer, hydronephrosis and Caprini RAM score was 0.826, 0.621 and 0.660, respectively. Based on the identified independent risk factors, the well-calibrated nomogram showed a moderate discriminative ability with concordance index 0.731.

Conclusions

2.8% of patients developed VTE following PCNL. Regarding those patients who have independent risk factors in this study, due attention should be paid to the effective thromboprophylaxis and the early detection of VTE.

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Title: Incidence and risk factors of venous thromboembolism after percutaneous nephrolithotomy: a single-center experience
Authors: Huimin Zeng
Meng Gao
Jinbo Chen
Yu Cui
Fang Huang
Feng Zeng
Zhongqing Yang
Yang Li
Zhiyong Chen
Zewu Zhu
Hequn Chen
Publication date: 01-09-2021
Publisher: Springer Berlin Heidelberg
Keywords: Venous Thrombosis
Septicemia
Septicemia
Anticoagulant
Septic Shock
Venous Thrombosis
Published in: World Journal of Urology / Issue 9/2021
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-021-03658-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Incidence and risk factors of venous thromboembolism after percutaneous nephrolithotomy: a single-center experience

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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