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Open Access 01-12-2022 | Vasculitis | Case report

Amyloid-β related angiitis presenting as eosinophilic meningitis: a case report

Authors: Jeremy A. Tanner, Megan B. Richie, Cathryn R. Cadwell, Amity Eliaz, Shannen Kim, Zeeshan Haq, Nailyn Rasool, Maulik P. Shah, Elan L. Guterman

Published in: BMC Neurology | Issue 1/2022

Abstract

Background

Eosinophilic meningitis is uncommon and often attributed to infectious causes.

Case presentation

We describe a case of a 72-year-old man who presented with subacute onset eosinophilic meningitis, vasculitis, and intracranial hypertension with progressive and severe neurologic symptoms. Brain MRI demonstrated multifocal strokes and co-localized right temporo-parieto-occipital vasogenic edema, cortical superficial siderosis, and diffuse leptomeningeal enhancement. He ultimately underwent brain biopsy with immunohistochemical stains for amyloid-β and Congo red that were extensively positive in the blood vessel walls and in numerous diffuse and neuritic parenchymal confirming a diagnosis of amyloid-β related angiitis. He was treated with immunosuppression with clinical stabilization.

Conclusions

Amyloid-β related angiitis is an underrecognized cause of eosinophilic meningitis that can present fulminantly and is typically responsive to immunosuppression. The presence of eosinophils may provide additional clues to the underlying pathophysiology of amyloid-β related angiitis.

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Title: Amyloid-β related angiitis presenting as eosinophilic meningitis: a case report
Authors: Jeremy A. Tanner
Megan B. Richie
Cathryn R. Cadwell
Amity Eliaz
Shannen Kim
Zeeshan Haq
Nailyn Rasool
Maulik P. Shah
Elan L. Guterman
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Vasculitis
Vasculitis
Edema
Meningitis
Intracranial Hypertension
Published in: BMC Neurology / Issue 1/2022
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-022-02638-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Amyloid-β related angiitis presenting as eosinophilic meningitis: a case report

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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