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Published in: Cardiology and Therapy 1/2021

Open Access 01-06-2021 | Varicosis | Review

Management of Lower Extremity Pain from Chronic Venous Insufficiency: A Comprehensive Review

Authors: Vwaire Orhurhu, Robert Chu, Katherine Xie, Ghislain N. Kamanyi, Bisola Salisu, Mariam Salisu-Orhurhu, Ivan Urits, Rachel J. Kaye, Jamal Hasoon, Omar Viswanath, Aaron J. Kaye, Jay Karri, Zwade Marshall, Alan D. Kaye, Dua Anahita

Published in: Cardiology and Therapy | Issue 1/2021

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Abstract

Purpose of Review

Chronic venous insufficiency is found to some extent in a large proportion of the world’s population, especially in the elderly and obese. Despite its prevalence, little research has been pursued into this pathology when compared to similarly common conditions. Pain is often the presenting symptom of chronic venous insufficiency and has significant deleterious effects on quality of life. This manuscript will describe the development of pain in chronic venous insufficiency, and will also review both traditional methods of pain management and novel advances in both medical and surgical therapy for this disease.

Recent Findings

Pain in chronic venous insufficiency is a common complication which remains poorly correlated in recent studies with the clinically observable extent of disease. Although lifestyle modification remains the foundation of treatment for pain associated with chronic venous sufficiency, compression devices and various pharmacologic agents have emerged as safe and effective treatments for pain in these patients. In patients for whom these measures are insufficient, recently developed minimally invasive vascular surgical techniques have been shown to reduce postsurgical complications and recovery time, although additional research is necessary to characterize long-term outcomes of these procedures.

Summary

This review discusses the latest findings concerning the pathophysiology of pain in chronic venous insufficiency, conservative and medical management, and surgical strategies for pain relief, including minimally invasive treatment strategies.
Literature
1.
go back to reference Beebe-Dimmer JL, et al. The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol. 2005;15(3):175–84.PubMed Beebe-Dimmer JL, et al. The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol. 2005;15(3):175–84.PubMed
2.
go back to reference Evans CJ, et al. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Commun H. 1999;53(3):149–53. Evans CJ, et al. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Commun H. 1999;53(3):149–53.
3.
go back to reference Criqui MH, et al. Chronic venous disease in an ethnically diverse population: the San Diego Population Study. Am J Epidemiol. 2003;158(5):448–56.PubMedPubMedCentral Criqui MH, et al. Chronic venous disease in an ethnically diverse population: the San Diego Population Study. Am J Epidemiol. 2003;158(5):448–56.PubMedPubMedCentral
4.
go back to reference Eberth-Willershausen W, Marshall M. Prevalence, risk factors and complications of peripheral venous diseases in the Munich population. Hautarzt. 1984;35(2):68–77.PubMed Eberth-Willershausen W, Marshall M. Prevalence, risk factors and complications of peripheral venous diseases in the Munich population. Hautarzt. 1984;35(2):68–77.PubMed
5.
go back to reference Adhikari A, et al. The epidemiology of chronic venous diseases. Phlebolymphology. 2004;47:299–303. Adhikari A, et al. The epidemiology of chronic venous diseases. Phlebolymphology. 2004;47:299–303.
6.
go back to reference Criqui MH, et al. Risk factors for chronic venous disease: the San Diego Population Study. J Vasc Surg. 2007;46(2):331–7.PubMedPubMedCentral Criqui MH, et al. Risk factors for chronic venous disease: the San Diego Population Study. J Vasc Surg. 2007;46(2):331–7.PubMedPubMedCentral
7.
go back to reference Brand FN, et al. The epidemiology of varicose veins: the Framingham Study. Am J Prev Med. 1988;4(2):96–101.PubMed Brand FN, et al. The epidemiology of varicose veins: the Framingham Study. Am J Prev Med. 1988;4(2):96–101.PubMed
8.
go back to reference Raetz J, Wilson M, Collins K. Varicose veins: diagnosis and treatment. Am Fam Physician. 2019;99(11):682–8.PubMed Raetz J, Wilson M, Collins K. Varicose veins: diagnosis and treatment. Am Fam Physician. 2019;99(11):682–8.PubMed
9.
go back to reference Boccalon H, et al. Characteristics of chronic venous insufficiency in 895 patients followed in general practice. Int Angiol. 1997;16(4):226–34.PubMed Boccalon H, et al. Characteristics of chronic venous insufficiency in 895 patients followed in general practice. Int Angiol. 1997;16(4):226–34.PubMed
10.
go back to reference Maffei FHA, et al. Varicose veins and chronic venous insufficiency in Brazil: prevalence among 1755 inhabitants of a country town. Int J Epidemiol. 1986;15(2):210–7.PubMed Maffei FHA, et al. Varicose veins and chronic venous insufficiency in Brazil: prevalence among 1755 inhabitants of a country town. Int J Epidemiol. 1986;15(2):210–7.PubMed
11.
go back to reference Rabe E, et al. Bonner venenstudie der deutschen gesellschaft für phlebologie. Phlebologie. 2003;32(01):1–14. Rabe E, et al. Bonner venenstudie der deutschen gesellschaft für phlebologie. Phlebologie. 2003;32(01):1–14.
12.
go back to reference Vuylsteke ME, et al. The influence of age and gender on venous symptomatology. An epidemiological survey in Belgium and Luxembourg. Phlebology. 2016;31(5):325–33.PubMed Vuylsteke ME, et al. The influence of age and gender on venous symptomatology. An epidemiological survey in Belgium and Luxembourg. Phlebology. 2016;31(5):325–33.PubMed
13.
go back to reference Criqui MH, et al. Epidemiology of chronic peripheral venous disease. In: The vein book. Amsterdam: Elsevier; 2007. p. 27–37. Criqui MH, et al. Epidemiology of chronic peripheral venous disease. In: The vein book. Amsterdam: Elsevier; 2007. p. 27–37.
14.
go back to reference Bonkemeyer Millan S, Gan R, Townsend PE. Venous ulcers: diagnosis and treatment. Am Fam Physician. 2019;100(5):298–305.PubMed Bonkemeyer Millan S, Gan R, Townsend PE. Venous ulcers: diagnosis and treatment. Am Fam Physician. 2019;100(5):298–305.PubMed
15.
go back to reference Mekky S, Schilling RSF, Walford J. Varicose veins in women cotton workers. An epidemiological study in England and Egypt. Br Med J. 1969;2(5657):591–5.PubMedPubMedCentral Mekky S, Schilling RSF, Walford J. Varicose veins in women cotton workers. An epidemiological study in England and Egypt. Br Med J. 1969;2(5657):591–5.PubMedPubMedCentral
16.
go back to reference Zolotukhin IA, et al. Prevalence and risk factors for chronic venous disease in the general Russian population. Eur J Vasc Endovasc Surg. 2017;54(6):752–8.PubMed Zolotukhin IA, et al. Prevalence and risk factors for chronic venous disease in the general Russian population. Eur J Vasc Endovasc Surg. 2017;54(6):752–8.PubMed
17.
go back to reference Dindelli M, et al. Risk factors for varicose disease before and during pregnancy. Angiology. 1993;44(5):361–7.PubMed Dindelli M, et al. Risk factors for varicose disease before and during pregnancy. Angiology. 1993;44(5):361–7.PubMed
18.
go back to reference Gourgou S, Dedieu F, Sancho-Garnier H. Lower limb venous insufficiency and tobacco smoking: a case-control study. Am J Epidemiol. 2002;155(11):1007–15.PubMed Gourgou S, Dedieu F, Sancho-Garnier H. Lower limb venous insufficiency and tobacco smoking: a case-control study. Am J Epidemiol. 2002;155(11):1007–15.PubMed
19.
go back to reference Abramson JH, Hopp C, Epstein LM. The epidemiology of varicose veins. A survey in western Jerusalem. J Epidemiol Commun H. 1981;35(3):213–7. Abramson JH, Hopp C, Epstein LM. The epidemiology of varicose veins. A survey in western Jerusalem. J Epidemiol Commun H. 1981;35(3):213–7.
20.
go back to reference Labropoulos N, Delis KT, Nicolaides AN. Venous reflux in symptom-free vascular surgeons. J Vasc Surg. 1995;22(2):150–4.PubMed Labropoulos N, Delis KT, Nicolaides AN. Venous reflux in symptom-free vascular surgeons. J Vasc Surg. 1995;22(2):150–4.PubMed
21.
go back to reference Tüchsen F, et al. Prolonged standing at work and hospitalisation due to varicose veins: a 12 year prospective study of the Danish population. Occup Environ Med. 2005;62(12):847–50.PubMedPubMedCentral Tüchsen F, et al. Prolonged standing at work and hospitalisation due to varicose veins: a 12 year prospective study of the Danish population. Occup Environ Med. 2005;62(12):847–50.PubMedPubMedCentral
22.
go back to reference Lee AJ, et al. Pregnancy, oral contraception, hormone replacement therapy and the occurrence of varicose veins: Edinburgh vein study. Phlebology. 1999;14(3):111–7. Lee AJ, et al. Pregnancy, oral contraception, hormone replacement therapy and the occurrence of varicose veins: Edinburgh vein study. Phlebology. 1999;14(3):111–7.
23.
go back to reference Eberhardt RT, Raffetto JD. Chronic venous insufficiency. Circulation. 2014;130(4):333–46.PubMed Eberhardt RT, Raffetto JD. Chronic venous insufficiency. Circulation. 2014;130(4):333–46.PubMed
24.
go back to reference Meissner MH, et al. The hemodynamics and diagnosis of venous disease. J Vasc Surg. 2007;46(6):S4–24. Meissner MH, et al. The hemodynamics and diagnosis of venous disease. J Vasc Surg. 2007;46(6):S4–24.
25.
go back to reference Labropoulos N, et al. Where does venous reflux start? J Vasc Surg. 1997;26(5):736–42.PubMed Labropoulos N, et al. Where does venous reflux start? J Vasc Surg. 1997;26(5):736–42.PubMed
26.
go back to reference Crawford JM, et al. Pathophysiology of venous ulceration. J Vasc Surg Venous Lymphat Disord. 2017;5(4):596–605.PubMed Crawford JM, et al. Pathophysiology of venous ulceration. J Vasc Surg Venous Lymphat Disord. 2017;5(4):596–605.PubMed
27.
go back to reference Miteva M, Romanelli P, Kirsner RS. Lipodermatosclerosis. Derm Ther. 2010;23(4):375–88. Miteva M, Romanelli P, Kirsner RS. Lipodermatosclerosis. Derm Ther. 2010;23(4):375–88.
28.
go back to reference Grosse SD, Nelson RE, Nyarko KA, Richardson LC, Raskob GE. The economic burden of incident venous thromboembolism in the United States: a review of estimated attributable healthcare costs. Thromb Res. 2016;137:3–10.PubMed Grosse SD, Nelson RE, Nyarko KA, Richardson LC, Raskob GE. The economic burden of incident venous thromboembolism in the United States: a review of estimated attributable healthcare costs. Thromb Res. 2016;137:3–10.PubMed
30.
go back to reference Di Nisio M, van Es N, Büller HR. Deep vein thrombosis and pulmonary embolism. Lancet. 2016;388(10063):3060–73.PubMed Di Nisio M, van Es N, Büller HR. Deep vein thrombosis and pulmonary embolism. Lancet. 2016;388(10063):3060–73.PubMed
31.
go back to reference Santler B, Goerge T. Chronic venous insufficiency—a review of pathophysiology, diagnosis, and treatment. J Dtsch Dermatol Ges. 2017;15(5):538–56.PubMed Santler B, Goerge T. Chronic venous insufficiency—a review of pathophysiology, diagnosis, and treatment. J Dtsch Dermatol Ges. 2017;15(5):538–56.PubMed
32.
go back to reference Bergan JJ, et al. Chronic venous disease. N Engl J Med. 2006;355(5):488–98.PubMed Bergan JJ, et al. Chronic venous disease. N Engl J Med. 2006;355(5):488–98.PubMed
33.
go back to reference Carpentier PH, et al. Appraisal of the information content of the C classes of CEAP clinical classification of chronic venous disorders: a multicenter evaluation of 872 patients. J Vasc Surg. 2003;37(4):827–33.PubMed Carpentier PH, et al. Appraisal of the information content of the C classes of CEAP clinical classification of chronic venous disorders: a multicenter evaluation of 872 patients. J Vasc Surg. 2003;37(4):827–33.PubMed
34.
go back to reference Lee AJ, et al. Progression of varicose veins and chronic venous insufficiency in the general population in the Edinburgh Vein Study. J Vasc Surg Venous Lymphat Disord. 2015;3(1):18–26.PubMed Lee AJ, et al. Progression of varicose veins and chronic venous insufficiency in the general population in the Edinburgh Vein Study. J Vasc Surg Venous Lymphat Disord. 2015;3(1):18–26.PubMed
35.
go back to reference Kaplan RM, et al. Quality of life in patients with chronic venous disease: San Diego population study. J Vasc Surg. 2003;37(5):1047–53.PubMed Kaplan RM, et al. Quality of life in patients with chronic venous disease: San Diego population study. J Vasc Surg. 2003;37(5):1047–53.PubMed
36.
go back to reference Green J, et al. The impact of chronic venous leg ulcers: a systematic review. J Wound Care. 2014;23(12):601–12.PubMed Green J, et al. The impact of chronic venous leg ulcers: a systematic review. J Wound Care. 2014;23(12):601–12.PubMed
37.
go back to reference Ruckley CV. Socioeconomic impact of chronic venous insufficiency and leg ulcers. Angiology. 1997;48(1):67–9.PubMed Ruckley CV. Socioeconomic impact of chronic venous insufficiency and leg ulcers. Angiology. 1997;48(1):67–9.PubMed
38.
go back to reference Van den Oever R, et al. Socio-economic impact of chronic venous insufficiency. An underestimated public health problem. Int Angiol. 1998;17(3):161–7.PubMed Van den Oever R, et al. Socio-economic impact of chronic venous insufficiency. An underestimated public health problem. Int Angiol. 1998;17(3):161–7.PubMed
39.
go back to reference Young YJ, Lee J. Chronic venous insufficiency and varicose veins of the lower extremities. Korean J Intern Med. 2019;34(2):269–83. Young YJ, Lee J. Chronic venous insufficiency and varicose veins of the lower extremities. Korean J Intern Med. 2019;34(2):269–83.
40.
go back to reference Lurie F, Passman M, Meisner M, Dalsing M, Masuda E, Welch H, Bush RL, Blebea J, Carpentier PH, De Maeseneer M, Gasparis A, Labropoulos N, Marston WA, Raffeto J, Santiago F, Shortell C, Uhl JF, Urbanek T, van Rij A, Eklof B, Gloviczki P, Kistner R, Lawrence P, Moneta G, Padberg F, Perrin M, Wakefield T. The 2020 update of the CEAP classification system and reporting standards. J Vasc Surg Venous Lymphat Disord. 2020;8(3):342–52.PubMed Lurie F, Passman M, Meisner M, Dalsing M, Masuda E, Welch H, Bush RL, Blebea J, Carpentier PH, De Maeseneer M, Gasparis A, Labropoulos N, Marston WA, Raffeto J, Santiago F, Shortell C, Uhl JF, Urbanek T, van Rij A, Eklof B, Gloviczki P, Kistner R, Lawrence P, Moneta G, Padberg F, Perrin M, Wakefield T. The 2020 update of the CEAP classification system and reporting standards. J Vasc Surg Venous Lymphat Disord. 2020;8(3):342–52.PubMed
41.
go back to reference Burrus MT, et al. Chronic leg pain in athletes. Am J Sport Med. 2015;43(6):1538–47. Burrus MT, et al. Chronic leg pain in athletes. Am J Sport Med. 2015;43(6):1538–47.
42.
go back to reference Branisteanu DE, et al. Impact of chronic venous disease on quality of life: results of vein alarm study. Exp Ther Med. 2019;17(2):1091–6.PubMed Branisteanu DE, et al. Impact of chronic venous disease on quality of life: results of vein alarm study. Exp Ther Med. 2019;17(2):1091–6.PubMed
43.
go back to reference Escudero Rodríguez JR, Fernández Quesada F, Bellmunt Montoya S. Prevalence and clinical characteristics of chronic venous disease in patients seen in primary care in Spain: results of the international study vein consult program. Cir Espan. 2014;92(8):539–46. Escudero Rodríguez JR, Fernández Quesada F, Bellmunt Montoya S. Prevalence and clinical characteristics of chronic venous disease in patients seen in primary care in Spain: results of the international study vein consult program. Cir Espan. 2014;92(8):539–46.
44.
go back to reference Aguilar-Ferrándiz ME, et al. Evaluation of pain associated with chronic venous insufficiency in Spanish postmenopausal women. Menopause. 2015;22(1):88–95.PubMed Aguilar-Ferrándiz ME, et al. Evaluation of pain associated with chronic venous insufficiency in Spanish postmenopausal women. Menopause. 2015;22(1):88–95.PubMed
45.
go back to reference Andreozzi G, et al. Quality of life in chronic venous insufficiency. Int Angiol. 2005;24(3):272e7. Andreozzi G, et al. Quality of life in chronic venous insufficiency. Int Angiol. 2005;24(3):272e7.
46.
47.
go back to reference Danziger N. Physiopathologie de la douleur au cours de la maladie veineuse. J Mal Vascul. 2007;32(1):1–7. Danziger N. Physiopathologie de la douleur au cours de la maladie veineuse. J Mal Vascul. 2007;32(1):1–7.
48.
go back to reference Lim RKS, et al. Visceral receptors concerned in visceral pain and the pseudaffective response to intra-arterial injection of bradykinin and other algesic agents. J Comp Neurol. 1962;118(3):269–93.PubMed Lim RKS, et al. Visceral receptors concerned in visceral pain and the pseudaffective response to intra-arterial injection of bradykinin and other algesic agents. J Comp Neurol. 1962;118(3):269–93.PubMed
49.
go back to reference Mansilha A, Sousa J. Pathophysiological mechanisms of chronic venous disease and implications for venoactive drug therapy. Int J Mol Sci. 2018;19(6):1669.PubMedCentral Mansilha A, Sousa J. Pathophysiological mechanisms of chronic venous disease and implications for venoactive drug therapy. Int J Mol Sci. 2018;19(6):1669.PubMedCentral
50.
go back to reference Michiels C, Bouaziz N, Remacle J. Role of the endothelium and blood stasis in the appearance of varicose veins. Int Angiol. 2002;21(1):1–8.PubMed Michiels C, Bouaziz N, Remacle J. Role of the endothelium and blood stasis in the appearance of varicose veins. Int Angiol. 2002;21(1):1–8.PubMed
51.
go back to reference Takase S, Bergan JJ, Schmid-Schönbein G. Expression of adhesion molecules and cytokines on saphenous veins in chronic venous insufficiency. Ann Vasc Surg. 2000;14(5):427–35.PubMed Takase S, Bergan JJ, Schmid-Schönbein G. Expression of adhesion molecules and cytokines on saphenous veins in chronic venous insufficiency. Ann Vasc Surg. 2000;14(5):427–35.PubMed
52.
go back to reference Howlader MH, Coleridge Smith PD. Symptoms of chronic venous disease and association with systemic inflammatory markers. J Vasc Surg. 2003;38(5):950–4.PubMed Howlader MH, Coleridge Smith PD. Symptoms of chronic venous disease and association with systemic inflammatory markers. J Vasc Surg. 2003;38(5):950–4.PubMed
53.
go back to reference Newland MR, et al. Neuropathy and gait disturbances in patients with venous disease: a pilot study. Arch Dermatol. 2009;145(4):485–6.PubMed Newland MR, et al. Neuropathy and gait disturbances in patients with venous disease: a pilot study. Arch Dermatol. 2009;145(4):485–6.PubMed
54.
go back to reference Shami SK, et al. Peripheral nerve function in chronic venous insufficiency. Eur J Vasc Surg. 1993;7(2):195–200.PubMed Shami SK, et al. Peripheral nerve function in chronic venous insufficiency. Eur J Vasc Surg. 1993;7(2):195–200.PubMed
55.
go back to reference Reinhardt F, et al. Peripheral neuropathy in chronic venous insufficiency. Muscle Nerve. 2000;23(6):883–7.PubMed Reinhardt F, et al. Peripheral neuropathy in chronic venous insufficiency. Muscle Nerve. 2000;23(6):883–7.PubMed
56.
go back to reference Bradbury A, et al. The relationship between lower limb symptoms and superficial and deep venous reflux on duplex ultrasonography: the Edinburgh Vein Study. J Vasc Surg. 2000;32(5):921–31.PubMed Bradbury A, et al. The relationship between lower limb symptoms and superficial and deep venous reflux on duplex ultrasonography: the Edinburgh Vein Study. J Vasc Surg. 2000;32(5):921–31.PubMed
57.
go back to reference Duque MI, et al. Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of life. J Am Acad Dermatol. 2005;53(3):503–7. Duque MI, et al. Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of life. J Am Acad Dermatol. 2005;53(3):503–7.
58.
go back to reference Chiesa R, et al. Chronic venous disorders: correlation between visible signs, symptoms, and presence of functional disease. J Vasc Surg. 2007;46(2):322–30.PubMed Chiesa R, et al. Chronic venous disorders: correlation between visible signs, symptoms, and presence of functional disease. J Vasc Surg. 2007;46(2):322–30.PubMed
59.
go back to reference Wrona M, et al. Association of venous disorders with leg symptoms: results from the Bonn vein study 1. Eur J Vasc Endovasc Surg. 2015;50(3):360–7.PubMed Wrona M, et al. Association of venous disorders with leg symptoms: results from the Bonn vein study 1. Eur J Vasc Endovasc Surg. 2015;50(3):360–7.PubMed
60.
go back to reference Özdemir ÖÇ, Surmeli M. Conservative management of chronic venous insufficiency. In: Clinical physical therapy (2017). InTech, Houston. Özdemir ÖÇ, Surmeli M. Conservative management of chronic venous insufficiency. In: Clinical physical therapy (2017). InTech, Houston.
61.
go back to reference Abu-Own A, Scurr JH, Coleridge Smith PD. Effect of leg elevation on the skin microcirculation in chronic venous insufficiency. J Vasc Surg. 1994;20(5):705–10.PubMed Abu-Own A, Scurr JH, Coleridge Smith PD. Effect of leg elevation on the skin microcirculation in chronic venous insufficiency. J Vasc Surg. 1994;20(5):705–10.PubMed
62.
go back to reference Vaidyanathan S, et al. Chronic venous disorders of the lower limbs: a surgical approach. New York: Springer; 2014. Vaidyanathan S, et al. Chronic venous disorders of the lower limbs: a surgical approach. New York: Springer; 2014.
63.
go back to reference Nilsson A, Zhang Q, Styf J. The amplitude of pulse-synchronous oscillations varies with the level of intramuscular pressure in simulated compartment syndrome. J Exp Orthop. 2015;2(1):3.PubMedPubMedCentral Nilsson A, Zhang Q, Styf J. The amplitude of pulse-synchronous oscillations varies with the level of intramuscular pressure in simulated compartment syndrome. J Exp Orthop. 2015;2(1):3.PubMedPubMedCentral
64.
go back to reference Wiger P, Styf JR. Effects of limb elevation on abnormally increased intramuscular pressure, blood perfusion pressure, and foot sensation: an experimental study in humans. J Orthop Trauma. 1998;12(5):343–7.PubMed Wiger P, Styf JR. Effects of limb elevation on abnormally increased intramuscular pressure, blood perfusion pressure, and foot sensation: an experimental study in humans. J Orthop Trauma. 1998;12(5):343–7.PubMed
65.
go back to reference Simka M et al. Calf muscle pump dysfunction in the patients with severe chronic venous insufficiency. Phlebolymphology. 2004. 47. Simka M et al. Calf muscle pump dysfunction in the patients with severe chronic venous insufficiency. Phlebolymphology. 2004. 47.
66.
go back to reference Kügler C, Strunk M, Rudofsky G. Venous pressure dynamics of the healthy human leg. Role of muscle activity, joint mobility and anthropometric factors. J Vasc Res. 2001;38(1):20–9.PubMed Kügler C, Strunk M, Rudofsky G. Venous pressure dynamics of the healthy human leg. Role of muscle activity, joint mobility and anthropometric factors. J Vasc Res. 2001;38(1):20–9.PubMed
67.
go back to reference Stein PD, Yaekoub AY, Ahsan ST, et al. Ankle exercise and venous blood velocity. Thromb Haemost. 2009;101(6):1100–3.PubMed Stein PD, Yaekoub AY, Ahsan ST, et al. Ankle exercise and venous blood velocity. Thromb Haemost. 2009;101(6):1100–3.PubMed
68.
go back to reference Kwon OY, Jung DY, Kim Y, Cho SH, Yi CH. Effects of ankle exercise combined with deep breathing on blood flow velocity in the femoral vein. Aust J Physiother. 2003;49(4):253–8.PubMed Kwon OY, Jung DY, Kim Y, Cho SH, Yi CH. Effects of ankle exercise combined with deep breathing on blood flow velocity in the femoral vein. Aust J Physiother. 2003;49(4):253–8.PubMed
69.
go back to reference Kropp AT, Meiss AL, Guthoff AE, et al. The efficacy of forceful ankle and toe exercises to increase venous return: a comprehensive Doppler ultrasound study. Phlebology. 2018;33(5):330–7.PubMed Kropp AT, Meiss AL, Guthoff AE, et al. The efficacy of forceful ankle and toe exercises to increase venous return: a comprehensive Doppler ultrasound study. Phlebology. 2018;33(5):330–7.PubMed
70.
go back to reference O’Brien J, et al. Evaluating the effectiveness of a self-management exercise intervention on wound healing, functional ability and health-related quality of life outcomes in adults with venous leg ulcers: a randomised controlled trial. Int Wound J. 2017;14(1):130–7.PubMed O’Brien J, et al. Evaluating the effectiveness of a self-management exercise intervention on wound healing, functional ability and health-related quality of life outcomes in adults with venous leg ulcers: a randomised controlled trial. Int Wound J. 2017;14(1):130–7.PubMed
71.
go back to reference Yang D, Vandongen YK, Stacey MC. Effect of exercise on calf muscle pump function in patients with chronic venous disease. Br J Surg. 1999;86(3):338–41.PubMed Yang D, Vandongen YK, Stacey MC. Effect of exercise on calf muscle pump function in patients with chronic venous disease. Br J Surg. 1999;86(3):338–41.PubMed
72.
go back to reference Alguire P, Mathes B. Medical management of lower extremity chronic venous disease. UpToDate. 2012. Alguire P, Mathes B. Medical management of lower extremity chronic venous disease. UpToDate. 2012.
73.
go back to reference Kan YM, Delis KT. Hemodynamic effects of supervised calf muscle exercise in patients with venous leg ulceration: a prospective controlled study. Arch Surg. 2001;136(12):1364–9.PubMed Kan YM, Delis KT. Hemodynamic effects of supervised calf muscle exercise in patients with venous leg ulceration: a prospective controlled study. Arch Surg. 2001;136(12):1364–9.PubMed
74.
go back to reference Klonizakis M, et al. Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomized controlled feasibility trial. Br J Dermatol. 2018;178(5):1072–82.PubMedPubMedCentral Klonizakis M, et al. Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomized controlled feasibility trial. Br J Dermatol. 2018;178(5):1072–82.PubMedPubMedCentral
75.
go back to reference Mutlak O, Aslam M, Standfield N. The influence of exercise on ulcer healing in patients with chronic venous insufficiency. Int Angiol. 2018;37(2):160–8.PubMed Mutlak O, Aslam M, Standfield N. The influence of exercise on ulcer healing in patients with chronic venous insufficiency. Int Angiol. 2018;37(2):160–8.PubMed
76.
go back to reference Gianesini S, Tessari M, Bacciglieri P, et al. A specifically designed aquatic exercise protocol to reduce chronic lower limb edema. Phlebology. 2017;32(9):594–600.PubMed Gianesini S, Tessari M, Bacciglieri P, et al. A specifically designed aquatic exercise protocol to reduce chronic lower limb edema. Phlebology. 2017;32(9):594–600.PubMed
77.
go back to reference van Stralen KJ, Le Cessie S, Rosendaal FR, Doggen CJM. Regular sports activities decrease the risk of venous thrombosis. J Thromb Haemost. 2007;5(11):2186–92.PubMed van Stralen KJ, Le Cessie S, Rosendaal FR, Doggen CJM. Regular sports activities decrease the risk of venous thrombosis. J Thromb Haemost. 2007;5(11):2186–92.PubMed
78.
go back to reference Belgrado JP, Bourgeois P, Rõh N, Moraine JJ. Intermittent pneumatic compression in the treatment of Lymphedema-current state of knowledge. Eur J Lymphat Related Problems. 2007;17:4–11. Belgrado JP, Bourgeois P, Rõh N, Moraine JJ. Intermittent pneumatic compression in the treatment of Lymphedema-current state of knowledge. Eur J Lymphat Related Problems. 2007;17:4–11.
79.
go back to reference Comerota AJ. Intermittent pneumatic compression: physiologic and clinical basis to improve management of venous leg ulcers. J Vasc Surg. 2011;53(4):1121–9.PubMed Comerota AJ. Intermittent pneumatic compression: physiologic and clinical basis to improve management of venous leg ulcers. J Vasc Surg. 2011;53(4):1121–9.PubMed
81.
go back to reference Rabe E, et al. Indications for medical compression stockings in venous and lymphatic disorders: an evidence-based consensus statement. Phlebology. 2018;33(3):163–84.PubMed Rabe E, et al. Indications for medical compression stockings in venous and lymphatic disorders: an evidence-based consensus statement. Phlebology. 2018;33(3):163–84.PubMed
82.
go back to reference Blazek C, Amsler F, Blaettler W, et al. Compression hosiery for occupational leg symptoms and leg volume: a randomized crossover trial in a cohort of hairdressers. Phlebology. 2013;28(5):239–47.PubMed Blazek C, Amsler F, Blaettler W, et al. Compression hosiery for occupational leg symptoms and leg volume: a randomized crossover trial in a cohort of hairdressers. Phlebology. 2013;28(5):239–47.PubMed
83.
go back to reference Schul MW, Eaton T, Erdman B. Compression versus sclerotherapy for patients with isolated refluxing reticular veins and telangiectasia: a randomized trial comparing quality-of-life outcomes. Phlebology. 2011;26(4):148–56.PubMed Schul MW, Eaton T, Erdman B. Compression versus sclerotherapy for patients with isolated refluxing reticular veins and telangiectasia: a randomized trial comparing quality-of-life outcomes. Phlebology. 2011;26(4):148–56.PubMed
84.
go back to reference Brizzio E, Amsler F, Lun B, Blättler W. Comparison of low-strength compression stockings with bandages for the treatment of recalcitrant venous ulcers. J Vasc Surg. 2010;51(2):410–6.PubMed Brizzio E, Amsler F, Lun B, Blättler W. Comparison of low-strength compression stockings with bandages for the treatment of recalcitrant venous ulcers. J Vasc Surg. 2010;51(2):410–6.PubMed
85.
go back to reference Wong IKY, Andriessen A, Charles HE, et al. Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in patients with venous leg ulcers. J Eur Acad Dermatol Venereol. 2012;26(1):102–10.PubMed Wong IKY, Andriessen A, Charles HE, et al. Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in patients with venous leg ulcers. J Eur Acad Dermatol Venereol. 2012;26(1):102–10.PubMed
86.
go back to reference Aguilar-Ferrándiz ME, Moreno-Lorenzo C, Matarán-Peñarrocha GA, et al. Effect of a mixed Kinesio taping-compression technique on quality of life and clinical and gait parameters in postmenopausal women with chronic venous insufficiency: double-blinded, randomized controlled trial. Arch Phys Med Rehabil. 2014;95(7):1229–39.PubMed Aguilar-Ferrándiz ME, Moreno-Lorenzo C, Matarán-Peñarrocha GA, et al. Effect of a mixed Kinesio taping-compression technique on quality of life and clinical and gait parameters in postmenopausal women with chronic venous insufficiency: double-blinded, randomized controlled trial. Arch Phys Med Rehabil. 2014;95(7):1229–39.PubMed
87.
go back to reference Aguilar-Ferrándiz ME, Castro-Sánchez AM, Matarán-Peñarrocha GA, et al. A randomized controlled trial of a mixed Kinesio taping-compression technique on venous symptoms, pain, peripheral venous flow, clinical severity and overall health status in postmenopausal women with chronic venous insufficiency. Clin Rehabil. 2014;28(1):69–81.PubMed Aguilar-Ferrándiz ME, Castro-Sánchez AM, Matarán-Peñarrocha GA, et al. A randomized controlled trial of a mixed Kinesio taping-compression technique on venous symptoms, pain, peripheral venous flow, clinical severity and overall health status in postmenopausal women with chronic venous insufficiency. Clin Rehabil. 2014;28(1):69–81.PubMed
88.
go back to reference Berliner E, Ozbilgin B, Zarin DA. A systematic review of pneumatic compression for treatment of chronic venous insufficiency and venous ulcers. J Vasc Surg. 2003;37(3):539–44.PubMed Berliner E, Ozbilgin B, Zarin DA. A systematic review of pneumatic compression for treatment of chronic venous insufficiency and venous ulcers. J Vasc Surg. 2003;37(3):539–44.PubMed
89.
go back to reference Smith PC, et al. Sequential gradient pneumatic compression enhances venous ulcer healing: a randomized trial. Surgery. 1990;108(5):871–5.PubMed Smith PC, et al. Sequential gradient pneumatic compression enhances venous ulcer healing: a randomized trial. Surgery. 1990;108(5):871–5.PubMed
90.
go back to reference O’Meara S, et al. Compression for venous leg ulcers. Cochrane Database Syst Rev. 2012;11(11):CD000265.PubMed O’Meara S, et al. Compression for venous leg ulcers. Cochrane Database Syst Rev. 2012;11(11):CD000265.PubMed
91.
go back to reference Mariani F, Mattaliano V, Mosti G, et al. The treatment of venous leg ulcers with a specifically designed compression stocking kit. Phlebologie. 2008;37:191–7. Mariani F, Mattaliano V, Mosti G, et al. The treatment of venous leg ulcers with a specifically designed compression stocking kit. Phlebologie. 2008;37:191–7.
92.
go back to reference Jünger M, Wollina U, Kohnen R, Rabe E. Efficacy and tolerability of an ulcer compression stocking for therapy of chronic venous ulcer compared with a below-knee compression bandage: results from a prospective, randomized, multicentre trial. Curr Med Res Opin. 2004;20(10):1613–23.PubMed Jünger M, Wollina U, Kohnen R, Rabe E. Efficacy and tolerability of an ulcer compression stocking for therapy of chronic venous ulcer compared with a below-knee compression bandage: results from a prospective, randomized, multicentre trial. Curr Med Res Opin. 2004;20(10):1613–23.PubMed
93.
go back to reference Polignano R, Guarnera G, Bonadeo P. Evaluation of SurePress Comfort: a new compression system for the management of venous leg ulcers. J Wound Care. 2004;13(9):387–91.PubMed Polignano R, Guarnera G, Bonadeo P. Evaluation of SurePress Comfort: a new compression system for the management of venous leg ulcers. J Wound Care. 2004;13(9):387–91.PubMed
94.
go back to reference Koskal C, Bozkurt AK. Combination of hydrocolloid dressing and medical compression stockings versus Unna’s boot for the treatment of venous leg ulcers. Swiss Med Wkly. 2003;133(25–26):364–8. Koskal C, Bozkurt AK. Combination of hydrocolloid dressing and medical compression stockings versus Unna’s boot for the treatment of venous leg ulcers. Swiss Med Wkly. 2003;133(25–26):364–8.
95.
go back to reference Raju S, Hollis K, Neglen P. Use of compression stocking in chronic venous disease: patient compliance and efficacy. Ann Vasc Surg. 2007;21(6):790–5.PubMed Raju S, Hollis K, Neglen P. Use of compression stocking in chronic venous disease: patient compliance and efficacy. Ann Vasc Surg. 2007;21(6):790–5.PubMed
96.
go back to reference Jull AB, Mitchell N, Arroll J, et al. Factors influencing concordance with compression stockings after venous leg ulcer healing. J Wound Care. 2004;13(3):90–2.PubMed Jull AB, Mitchell N, Arroll J, et al. Factors influencing concordance with compression stockings after venous leg ulcer healing. J Wound Care. 2004;13(3):90–2.PubMed
97.
go back to reference Nicolaides AN, et al. Management of chronic venous disorders of the lower limbs: guidelines according to scientific evidence. Int Angiol. 2008;27(1):1–59.PubMed Nicolaides AN, et al. Management of chronic venous disorders of the lower limbs: guidelines according to scientific evidence. Int Angiol. 2008;27(1):1–59.PubMed
98.
go back to reference Bush R, et al. Recommendations for the medical management of chronic venous disease: the role of Micronized Purified Flavanoid Fraction (MPFF): recommendations from the Working Group in Chronic Venous Disease (CVD). Phlebology. 2017;32(1_suppl):3–19.PubMed Bush R, et al. Recommendations for the medical management of chronic venous disease: the role of Micronized Purified Flavanoid Fraction (MPFF): recommendations from the Working Group in Chronic Venous Disease (CVD). Phlebology. 2017;32(1_suppl):3–19.PubMed
99.
go back to reference Gloviczki P, et al. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011;53(5 Suppl):2s–48s.PubMed Gloviczki P, et al. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011;53(5 Suppl):2s–48s.PubMed
100.
go back to reference Ulloa JH. Micronized purified flavonoid fraction (MPFF) for patient suffering from chronic venous disease: a review of new evidence. Adv Ther. 2019;36(Supp1):20–5.PubMedPubMedCentral Ulloa JH. Micronized purified flavonoid fraction (MPFF) for patient suffering from chronic venous disease: a review of new evidence. Adv Ther. 2019;36(Supp1):20–5.PubMedPubMedCentral
101.
go back to reference das Graças CSM, Cyrino FZ, de Carvalho JJ, Blanc-Guillemaud V, Bouskela E. Protective effects of micronized purified flavonoid fraction (MPFF) on a novel experimental model of chronic venous hypertension. Eur J Vasc Endovasc Surg. 2018;55(5):694–702. das Graças CSM, Cyrino FZ, de Carvalho JJ, Blanc-Guillemaud V, Bouskela E. Protective effects of micronized purified flavonoid fraction (MPFF) on a novel experimental model of chronic venous hypertension. Eur J Vasc Endovasc Surg. 2018;55(5):694–702.
102.
go back to reference Kakkos SK, Nicolaides AN. Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials. Int Angiol. 2018;37(2):143–54.PubMed Kakkos SK, Nicolaides AN. Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials. Int Angiol. 2018;37(2):143–54.PubMed
103.
go back to reference Perrin M, Ramelet AA. Pharmacological treatment of primary chronic venous disease: rationale, results and unanswered questions. Eur J Vasc Endovasc Surg. 2011;41(1):117–25.PubMed Perrin M, Ramelet AA. Pharmacological treatment of primary chronic venous disease: rationale, results and unanswered questions. Eur J Vasc Endovasc Surg. 2011;41(1):117–25.PubMed
104.
go back to reference Rabe E, Agus GB, Roztocil K. Analysis of the effects of micronized purified flavonoid fraction versus placebo on symptoms and quality of life in patients suffering from chronic venous disease: from a prospective randomized trial. Int Angiol. 2015;34:428–36.PubMed Rabe E, Agus GB, Roztocil K. Analysis of the effects of micronized purified flavonoid fraction versus placebo on symptoms and quality of life in patients suffering from chronic venous disease: from a prospective randomized trial. Int Angiol. 2015;34:428–36.PubMed
105.
go back to reference Danielsson G, Jungbeck C, Peterson K, Norgren L. A randomised controlled trial of micronised purified flavonoid fraction vs placebo in patients with chronic venous disease. Eur J Vasc Endovasc Surg. 2002;23:73–6.PubMed Danielsson G, Jungbeck C, Peterson K, Norgren L. A randomised controlled trial of micronised purified flavonoid fraction vs placebo in patients with chronic venous disease. Eur J Vasc Endovasc Surg. 2002;23:73–6.PubMed
106.
go back to reference Gavrilov SG, Moskalenko YP, Karalkin AV. Effectiveness and safety of micronized purified flavonoid fraction for the treatment of concomitant varicose veins of the pelvis and lower extremities. Curr Med Res Opin. 2019;35(6):1019–26.PubMed Gavrilov SG, Moskalenko YP, Karalkin AV. Effectiveness and safety of micronized purified flavonoid fraction for the treatment of concomitant varicose veins of the pelvis and lower extremities. Curr Med Res Opin. 2019;35(6):1019–26.PubMed
107.
go back to reference Carpentier P, van Bellen B, Karetova D, et al. Clinical efficacy and safety of a new 1000-mg suspension versus twice-daily 500-mg tablets of MPFF in patients with symptomatic chronic venous disorders: a randomized controlled trial. Int Angiol. 2017;36(5):402–9.PubMed Carpentier P, van Bellen B, Karetova D, et al. Clinical efficacy and safety of a new 1000-mg suspension versus twice-daily 500-mg tablets of MPFF in patients with symptomatic chronic venous disorders: a randomized controlled trial. Int Angiol. 2017;36(5):402–9.PubMed
108.
go back to reference Ulloa JH, Guerra D, Cadavid LG, Fajardo D, Villarreal R, Bayon G, et al. Nonoperative approach for symptomatic patients with chronic venous disease: results from the VEIN Act program. Phlebolymphology. 2018;25(2):123. Ulloa JH, Guerra D, Cadavid LG, Fajardo D, Villarreal R, Bayon G, et al. Nonoperative approach for symptomatic patients with chronic venous disease: results from the VEIN Act program. Phlebolymphology. 2018;25(2):123.
109.
go back to reference Lishkov DE, Kirienko AI, Larionov AA, Chernookov AI. Patients seeking treatment for chronic venous disorders: Russian results from the VEIN Act program. Phlebolymphology. 2016;23(1):44. Lishkov DE, Kirienko AI, Larionov AA, Chernookov AI. Patients seeking treatment for chronic venous disorders: Russian results from the VEIN Act program. Phlebolymphology. 2016;23(1):44.
110.
go back to reference Guilhou J-J, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology. 1997;48(1):77–85.PubMed Guilhou J-J, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology. 1997;48(1):77–85.PubMed
111.
go back to reference Smith PC. Daflon 500 mg and venous leg ulcer: new results from a meta-analysis. Angiology. 2005;56(6_suppl):S33–9.PubMed Smith PC. Daflon 500 mg and venous leg ulcer: new results from a meta-analysis. Angiology. 2005;56(6_suppl):S33–9.PubMed
112.
go back to reference Nicolaides AN. The benefit of micronized purified flavonoid fraction (MPFF) throughout the progression of chronic venous disease. Adv Ther. 2020;37(Suppl 1):1–5.PubMedPubMedCentral Nicolaides AN. The benefit of micronized purified flavonoid fraction (MPFF) throughout the progression of chronic venous disease. Adv Ther. 2020;37(Suppl 1):1–5.PubMedPubMedCentral
113.
go back to reference Bogachev VY, Boldin BV, Turkin PY. Administration of micronized purified flavonoid fraction during sclerotherapy of reticular veins and telangiectasias: results of the National, Multicenter, Observational Program VEIN ACT PROLONGED-C1. Adv Ther. 2018;35(7):1001–8.PubMed Bogachev VY, Boldin BV, Turkin PY. Administration of micronized purified flavonoid fraction during sclerotherapy of reticular veins and telangiectasias: results of the National, Multicenter, Observational Program VEIN ACT PROLONGED-C1. Adv Ther. 2018;35(7):1001–8.PubMed
114.
go back to reference Bogachev VY, Golovanova OV, Kuzhetsov AN, Shekoian AO. The DECISION Investigators Can micronized purified flavonoid fraction* (MPFF) improve outcomes of lower extremity varicose vein endovenous treatment? First results from the DECISION study. Phlebolymphology. 2013;20(4):181–7. Bogachev VY, Golovanova OV, Kuzhetsov AN, Shekoian AO. The DECISION Investigators Can micronized purified flavonoid fraction* (MPFF) improve outcomes of lower extremity varicose vein endovenous treatment? First results from the DECISION study. Phlebolymphology. 2013;20(4):181–7.
115.
go back to reference Lyseng-Williamson KA, Perry CM. Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids. Drugs. 2003;63(1):71–100.PubMed Lyseng-Williamson KA, Perry CM. Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids. Drugs. 2003;63(1):71–100.PubMed
116.
go back to reference Sintori CR. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Pharm Res. 2001;44(3):183–93. Sintori CR. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Pharm Res. 2001;44(3):183–93.
117.
go back to reference Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012;11:CD003230.PubMed Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012;11:CD003230.PubMed
118.
go back to reference Gallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Des Dev Ther. 2019;13:3425–37. Gallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Des Dev Ther. 2019;13:3425–37.
119.
go back to reference Zhao SQ, Xu SQ, Cheng J, et al. Anti-inflammatory effect of external use of escin on cutaneous inflammation: possible involvement of glucocorticoids receptor. Chin J Nat Med. 2018;16(2):105–12.PubMed Zhao SQ, Xu SQ, Cheng J, et al. Anti-inflammatory effect of external use of escin on cutaneous inflammation: possible involvement of glucocorticoids receptor. Chin J Nat Med. 2018;16(2):105–12.PubMed
120.
go back to reference Xin W, Zhang L, Sun F, et al. Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro. Phytomedicine. 2011;18(4):272–7.PubMed Xin W, Zhang L, Sun F, et al. Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro. Phytomedicine. 2011;18(4):272–7.PubMed
121.
go back to reference Brunner F, Hoffmann C, Schuller-Petrovic S. Responsiveness of human varicose saphenous veins to vasoactive agents. Br J Clin Pharmacol. 2001;51(3):219–24.PubMedPubMedCentral Brunner F, Hoffmann C, Schuller-Petrovic S. Responsiveness of human varicose saphenous veins to vasoactive agents. Br J Clin Pharmacol. 2001;51(3):219–24.PubMedPubMedCentral
122.
go back to reference Diehm C, et al. Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet. 1996;347(8997):292–4.PubMed Diehm C, et al. Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet. 1996;347(8997):292–4.PubMed
123.
go back to reference Suter A, Bommer S, Rechner J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies. Adv Ther. 2006;23(1):179–90.PubMed Suter A, Bommer S, Rechner J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies. Adv Ther. 2006;23(1):179–90.PubMed
124.
go back to reference Edem E, Kahyaoglu B, Çakar MA. Acute effusive pericarditis due to horse chestnut consumption. Am J Case Rep. 2016;17:305–8.PubMedPubMedCentral Edem E, Kahyaoglu B, Çakar MA. Acute effusive pericarditis due to horse chestnut consumption. Am J Case Rep. 2016;17:305–8.PubMedPubMedCentral
125.
go back to reference Alda O, Valero MS, Pereboom D. In vitro effect of calcium dobesilate on oxidative/inflammatory stress in human varicose veins. Phlebology. 2011;26(8):332–7.PubMed Alda O, Valero MS, Pereboom D. In vitro effect of calcium dobesilate on oxidative/inflammatory stress in human varicose veins. Phlebology. 2011;26(8):332–7.PubMed
126.
go back to reference Rabe E, Jaeger KA, Bulitta M, Pannier F. Calcium dobesilate in patients suffering from chronic venous insufficiency: a double-blind, placebo-controlled, clinical trial. Phlebology. 2011;26(4):162–8.PubMed Rabe E, Jaeger KA, Bulitta M, Pannier F. Calcium dobesilate in patients suffering from chronic venous insufficiency: a double-blind, placebo-controlled, clinical trial. Phlebology. 2011;26(4):162–8.PubMed
127.
go back to reference Rabe E, Ballarini S, Lehr L. A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency. Phlebology. 2015;31(4):264–74.PubMed Rabe E, Ballarini S, Lehr L. A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency. Phlebology. 2015;31(4):264–74.PubMed
128.
go back to reference Flota-Cervera F, Flota-Ruiz C, Treviño C, Berber A. Randomized, double blind, placebo-controlled clinical trial to evaluate the lymphagogue effect and clinical efficacy of calcium dobesilate in chronic venous disease. Angiology. 2008;59(3):352–6.PubMed Flota-Cervera F, Flota-Ruiz C, Treviño C, Berber A. Randomized, double blind, placebo-controlled clinical trial to evaluate the lymphagogue effect and clinical efficacy of calcium dobesilate in chronic venous disease. Angiology. 2008;59(3):352–6.PubMed
129.
go back to reference Ciapponi A, Laffaire E, Roqué M. Calcium dobesilate for chronic venous insufficiency: a systematic review. Angiology. 2004;55(2):147–54.PubMed Ciapponi A, Laffaire E, Roqué M. Calcium dobesilate for chronic venous insufficiency: a systematic review. Angiology. 2004;55(2):147–54.PubMed
130.
go back to reference Martínez-Zapata MJ, et al. A randomized, double-blind multicentre clinical trial comparing the efficacy of calcium dobesilate with placebo in the treatment of chronic venous disease. Eur J Vasc Endovasc Surg. 2008;35(3):358–65.PubMed Martínez-Zapata MJ, et al. A randomized, double-blind multicentre clinical trial comparing the efficacy of calcium dobesilate with placebo in the treatment of chronic venous disease. Eur J Vasc Endovasc Surg. 2008;35(3):358–65.PubMed
131.
go back to reference Martinez-Zapata MJ, Vernooij RWM, Uriona Tuma SM, et al. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2016;4:CD003229.PubMed Martinez-Zapata MJ, Vernooij RWM, Uriona Tuma SM, et al. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2016;4:CD003229.PubMed
132.
go back to reference Stücker M, Rabe E, Meyer K, Ottillinger B, Schütt T. Therapeutic approach to chronic venous insufficiency: clinical benefits of red vine leaf extract AS 195 (Antistax®). Pharmazie. 2019;74(4):193–200.PubMed Stücker M, Rabe E, Meyer K, Ottillinger B, Schütt T. Therapeutic approach to chronic venous insufficiency: clinical benefits of red vine leaf extract AS 195 (Antistax®). Pharmazie. 2019;74(4):193–200.PubMed
133.
go back to reference Grau M, Bölck B, Bizjak DA, Stabenow CJA, Bloch W. The red vine leaf extract AS195 increases nitric oxide synthase-dependent nitric oxide generation and decreases oxidative stress in endothelial and red blood cells. Pharmacol Res Perspect. 2016;4(1):e00213.PubMedPubMedCentral Grau M, Bölck B, Bizjak DA, Stabenow CJA, Bloch W. The red vine leaf extract AS195 increases nitric oxide synthase-dependent nitric oxide generation and decreases oxidative stress in endothelial and red blood cells. Pharmacol Res Perspect. 2016;4(1):e00213.PubMedPubMedCentral
134.
go back to reference Nees S, Weiss DR, Reichenbach-Klinke E, et al. Protective effects of flavonoids contained in the red vine leaf on venular endothelium against the attack of activated blood components in vitro. Arzneimittelforschung. 2003;53(5):330–41.PubMed Nees S, Weiss DR, Reichenbach-Klinke E, et al. Protective effects of flavonoids contained in the red vine leaf on venular endothelium against the attack of activated blood components in vitro. Arzneimittelforschung. 2003;53(5):330–41.PubMed
135.
go back to reference Kalus U, Koscielny J, Grigorov A, et al. Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R D. 2004;5(2):63–71.PubMed Kalus U, Koscielny J, Grigorov A, et al. Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R D. 2004;5(2):63–71.PubMed
136.
go back to reference Schaefer E, Peil H, Ambrosetti L, Petrini O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency: a 6-week observational clinical trial. Arzneimittelforschung. 2003;53(4):243–6.PubMed Schaefer E, Peil H, Ambrosetti L, Petrini O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency: a 6-week observational clinical trial. Arzneimittelforschung. 2003;53(4):243–6.PubMed
137.
go back to reference Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II): a randomized, double-blind, placebo-controlled trial. Arzneimittelforschung. 2000;50(2):109–17.PubMed Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II): a randomized, double-blind, placebo-controlled trial. Arzneimittelforschung. 2000;50(2):109–17.PubMed
138.
go back to reference Rabe E, Stücker E, Esperester A, Schäfer E, Ottillinger B. Efficacy and tolerability of a red vine leaf extract in patients suffering from chronic venous disease: results of a double-blind placebo-controlled study. Eur J Endovasc Surg. 2011;41(4):540–7. Rabe E, Stücker E, Esperester A, Schäfer E, Ottillinger B. Efficacy and tolerability of a red vine leaf extract in patients suffering from chronic venous disease: results of a double-blind placebo-controlled study. Eur J Endovasc Surg. 2011;41(4):540–7.
139.
go back to reference Monsieur R, Van Snick G. Efficacy of the red vine leaf extract AS 195 in chronic venous insufficiency. Praxis (Bern 1994). 2006;95(6):187–90. Monsieur R, Van Snick G. Efficacy of the red vine leaf extract AS 195 in chronic venous insufficiency. Praxis (Bern 1994). 2006;95(6):187–90.
140.
go back to reference Azhdari M, Zilaee M, Karandish M, et al. Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review. Phytother Res. 2020;34(10):2577–85.PubMed Azhdari M, Zilaee M, Karandish M, et al. Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review. Phytother Res. 2020;34(10):2577–85.PubMed
141.
go back to reference Jull A, Waters J, Arroll B. Pentoxifylline for treatment of venous leg ulcers: a systematic review. Lancet. 2002;359(9317):1550–4.PubMed Jull A, Waters J, Arroll B. Pentoxifylline for treatment of venous leg ulcers: a systematic review. Lancet. 2002;359(9317):1550–4.PubMed
142.
go back to reference Krakauer T. Pentoxifylline inhibits ICAM-1 expression and chemokine production induced by proinflammatory cytokines in human pulmonary epithelial cells. Immunopharmacology. 2000;46(3):253–61.PubMed Krakauer T. Pentoxifylline inhibits ICAM-1 expression and chemokine production induced by proinflammatory cytokines in human pulmonary epithelial cells. Immunopharmacology. 2000;46(3):253–61.PubMed
143.
go back to reference Smith PDC. Drug treatment of varicose veins, venous edema, and ulcers. In: Gloviczki P, editor. Handbook of venous and lymphatic disorders: guidelines of the American venous forum. Boca Raton: CRC Press; 2017. p. 391–8. Smith PDC. Drug treatment of varicose veins, venous edema, and ulcers. In: Gloviczki P, editor. Handbook of venous and lymphatic disorders: guidelines of the American venous forum. Boca Raton: CRC Press; 2017. p. 391–8.
144.
go back to reference Jull AB, Arroll B, Parag V, Waters J. Pentoxifylline for treating venous leg ulcers. Cochrane Database Syst Rev. 2012;2012(12):CD001733.PubMedCentral Jull AB, Arroll B, Parag V, Waters J. Pentoxifylline for treating venous leg ulcers. Cochrane Database Syst Rev. 2012;2012(12):CD001733.PubMedCentral
145.
go back to reference Wollina U, Abdel-Naser MB, Mani R. A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options. Int J Low Extrem Wounds. 2006;593:169–80. Wollina U, Abdel-Naser MB, Mani R. A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options. Int J Low Extrem Wounds. 2006;593:169–80.
146.
go back to reference Belcaro G, Cesarone MR, Nicolaides AN, et al. Treatment of venous ulcers with pentoxifylline: a 6-month randomized, double-blind, placebo controlled trial. Angiology. 2002;53(Suppl 1):S45–7.PubMed Belcaro G, Cesarone MR, Nicolaides AN, et al. Treatment of venous ulcers with pentoxifylline: a 6-month randomized, double-blind, placebo controlled trial. Angiology. 2002;53(Suppl 1):S45–7.PubMed
147.
go back to reference Parsa H, Zangivand AA, Hajimaghsoudi L. The effect of pentoxifylline on chronic venous ulcers. Wounds. 2012;24(7):190–4.PubMed Parsa H, Zangivand AA, Hajimaghsoudi L. The effect of pentoxifylline on chronic venous ulcers. Wounds. 2012;24(7):190–4.PubMed
148.
go back to reference Nikolovska S, Pavlova L, Petrova N, Gocev G, Ivanovski M. Pentoxifylline: efficient in the treatment of venous ulcers in the absence of compression? Acta Dermatovenerol Croat. 2002;10(1):9–13.PubMed Nikolovska S, Pavlova L, Petrova N, Gocev G, Ivanovski M. Pentoxifylline: efficient in the treatment of venous ulcers in the absence of compression? Acta Dermatovenerol Croat. 2002;10(1):9–13.PubMed
149.
go back to reference Lacroix I, et al. First epidemiological data for venotonics in pregnancy from the EFEMERIS database. Phlebology. 2016;31(5):344–8.PubMed Lacroix I, et al. First epidemiological data for venotonics in pregnancy from the EFEMERIS database. Phlebology. 2016;31(5):344–8.PubMed
150.
go back to reference Wittens C, et al. Editor’s choice—management of chronic venous disease: clinical practice guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg. 2015;49(6):678–737.PubMed Wittens C, et al. Editor’s choice—management of chronic venous disease: clinical practice guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg. 2015;49(6):678–737.PubMed
151.
go back to reference Kam MH, Tan SG. Results of long saphenous vein stripping. Singapore Med J. 2003;44(12):639–42.PubMed Kam MH, Tan SG. Results of long saphenous vein stripping. Singapore Med J. 2003;44(12):639–42.PubMed
152.
go back to reference Michaels JA, Brazier JE, Campbell WB, et al. Randomized clinical trial comparing surgery with conservative treatment for uncomplicated varicose veins. Br J Surg. 2006;93(2):175–81.PubMed Michaels JA, Brazier JE, Campbell WB, et al. Randomized clinical trial comparing surgery with conservative treatment for uncomplicated varicose veins. Br J Surg. 2006;93(2):175–81.PubMed
153.
go back to reference Krasznai AG, Sigterman TA, Houtermans-Auckel JP, et al. A randomised controlled trial comparing compression therapy after stripping for primary great saphenous vein incompetence. Phlebology. 2019;34(10):669–74.PubMed Krasznai AG, Sigterman TA, Houtermans-Auckel JP, et al. A randomised controlled trial comparing compression therapy after stripping for primary great saphenous vein incompetence. Phlebology. 2019;34(10):669–74.PubMed
154.
go back to reference Houtermans-Auckel JP, van Rossum E, Teijink JAW. To wear or not to wear compression stockings after varicose vein stripping: a randomised controlled trial. Eur J Vasc Endovasc Surg. 2009;38(3):387–91.PubMed Houtermans-Auckel JP, van Rossum E, Teijink JAW. To wear or not to wear compression stockings after varicose vein stripping: a randomised controlled trial. Eur J Vasc Endovasc Surg. 2009;38(3):387–91.PubMed
155.
go back to reference Kianifard B, Holdstock J, Allen C, et al. Randomized clinical trial of the effect of adding subfascial endoscopic perforator surgery to standard great saphenous vein stripping. Br J Surg. 2007;94(9):1075–80.PubMed Kianifard B, Holdstock J, Allen C, et al. Randomized clinical trial of the effect of adding subfascial endoscopic perforator surgery to standard great saphenous vein stripping. Br J Surg. 2007;94(9):1075–80.PubMed
156.
go back to reference Lin ZC, Loveland PM, Johnston RV, et al. Subfascial endoscopic perforator surgery (SEPS) for treating venous leg ulcers. Cochrane Database Syst Rev. 2019;2019(3):CD012164.PubMedCentral Lin ZC, Loveland PM, Johnston RV, et al. Subfascial endoscopic perforator surgery (SEPS) for treating venous leg ulcers. Cochrane Database Syst Rev. 2019;2019(3):CD012164.PubMedCentral
157.
go back to reference Zhan HT, Bush RL. A review of the current management and treatment options for superficial venous insufficiency. World J Surg. 2014;38(10):2580–8.PubMed Zhan HT, Bush RL. A review of the current management and treatment options for superficial venous insufficiency. World J Surg. 2014;38(10):2580–8.PubMed
158.
go back to reference de Zeeuw R, Wittens C, Loots M, Neumann M. Transilluminated powered phlebectomy accomplished by local tumescent anaesthesia in the treatment of tributary varicose veins: preliminary clinical results. Phlebology. 2007;22(2):90–4.PubMed de Zeeuw R, Wittens C, Loots M, Neumann M. Transilluminated powered phlebectomy accomplished by local tumescent anaesthesia in the treatment of tributary varicose veins: preliminary clinical results. Phlebology. 2007;22(2):90–4.PubMed
159.
go back to reference Scavée V, Lemaire E, Haxhe JP. Transilluminated powered phlebectomy: mid-term clinical experience. Int Angiol. 2005;24(1):75–9.PubMed Scavée V, Lemaire E, Haxhe JP. Transilluminated powered phlebectomy: mid-term clinical experience. Int Angiol. 2005;24(1):75–9.PubMed
160.
go back to reference Luebke T, Brunkwall J. Meta-analysis of transilluminated powered phlebectomy for superficial varicosities. J Cardiovasc Surg (Torino). 2008;49(6):757–64. Luebke T, Brunkwall J. Meta-analysis of transilluminated powered phlebectomy for superficial varicosities. J Cardiovasc Surg (Torino). 2008;49(6):757–64.
161.
go back to reference Chetter IC, Mylankal KJ, Hughes H, Fitridge R. Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins. Br J Surg. 2006;93(2):169–74.PubMed Chetter IC, Mylankal KJ, Hughes H, Fitridge R. Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins. Br J Surg. 2006;93(2):169–74.PubMed
162.
go back to reference Aremu MA, Mahendran B, Butcher W, et al. Prospective randomized controlled trial: conventional versus powered phlebectomy. J Vasc Surg. 2004;39(1):88–94.PubMed Aremu MA, Mahendran B, Butcher W, et al. Prospective randomized controlled trial: conventional versus powered phlebectomy. J Vasc Surg. 2004;39(1):88–94.PubMed
163.
go back to reference Scavée V, Lesceu O, Theys S, et al. Hook phlebectomy versus transillumination powered phlebectomy for varicose vein surgery: early results. Eur J Vasc Endovasc Surg. 2003;25(5):473–5.PubMed Scavée V, Lesceu O, Theys S, et al. Hook phlebectomy versus transillumination powered phlebectomy for varicose vein surgery: early results. Eur J Vasc Endovasc Surg. 2003;25(5):473–5.PubMed
164.
go back to reference Carradice D, Mekako AI, Hatfield J, Chetter IC. Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins. Br J Surg. 2009;96(4):369–75.PubMed Carradice D, Mekako AI, Hatfield J, Chetter IC. Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins. Br J Surg. 2009;96(4):369–75.PubMed
165.
go back to reference Obi AT, Reames BN, Rook TJ, et al. Outcomes associated with ablation compared to combined ablation and transilluminated powered phlebectomy in the treatment of venous varicosities. Phlebology. 2016;31(9):618–24.PubMed Obi AT, Reames BN, Rook TJ, et al. Outcomes associated with ablation compared to combined ablation and transilluminated powered phlebectomy in the treatment of venous varicosities. Phlebology. 2016;31(9):618–24.PubMed
166.
go back to reference Kawai Y, Sugimoto M, Aikawa K, Komori K. Endovenous laser ablation with and without concomitant phlebectomy for the treatment of varicose veins: a retrospective analysis of 954 limbs. Ann Vasc Surg. 2020;66:344–50.PubMed Kawai Y, Sugimoto M, Aikawa K, Komori K. Endovenous laser ablation with and without concomitant phlebectomy for the treatment of varicose veins: a retrospective analysis of 954 limbs. Ann Vasc Surg. 2020;66:344–50.PubMed
167.
go back to reference Mekako A, Hatfield J, Bryce J, et al. Combined endovenous laser therapy and ambulatory phlebectomy: refinement of a new technique. Eur J Vasc Endovasc Surg. 2006;32(6):725–9.PubMed Mekako A, Hatfield J, Bryce J, et al. Combined endovenous laser therapy and ambulatory phlebectomy: refinement of a new technique. Eur J Vasc Endovasc Surg. 2006;32(6):725–9.PubMed
168.
go back to reference Parés JO, Juan J, Tellez R, et al. Varicose vein surgery: stripping versus the CHIVA method: a randomized controlled trial. Ann Surg. 2010;251(4):624–31.PubMed Parés JO, Juan J, Tellez R, et al. Varicose vein surgery: stripping versus the CHIVA method: a randomized controlled trial. Ann Surg. 2010;251(4):624–31.PubMed
169.
go back to reference Carandina S, Mari C, De Palma M, et al. Varicose vein stripping vs haemodynamic correction (CHIVA): a long term randomised trial. Eur J Vasc Endovas Surg. 2008;35(2):230–7. Carandina S, Mari C, De Palma M, et al. Varicose vein stripping vs haemodynamic correction (CHIVA): a long term randomised trial. Eur J Vasc Endovas Surg. 2008;35(2):230–7.
170.
go back to reference Zamboni P, Cisno C, Marchetti F, et al. Haemodynamic CHIVA correction surgery versus compression of primary venous ulcers: first year results. Phlebology. 2004;19(1):28–34. Zamboni P, Cisno C, Marchetti F, et al. Haemodynamic CHIVA correction surgery versus compression of primary venous ulcers: first year results. Phlebology. 2004;19(1):28–34.
171.
go back to reference Maeso J, Juan J, Maria Escribano J, et al. Comparison of clinical outcome of stripping and CHIVA for treatment of varicose veins in the lower extremities. Ann Vasc Surg. 2001;15(6):661–5.PubMed Maeso J, Juan J, Maria Escribano J, et al. Comparison of clinical outcome of stripping and CHIVA for treatment of varicose veins in the lower extremities. Ann Vasc Surg. 2001;15(6):661–5.PubMed
172.
go back to reference González Cañas E, Florit López S, Vives Vilagut R, et al. A randomized controlled noninferiority trial comparing radiofrequency with stripping and conservative hemodynamic cure for venous insufficiency technique for insufficiency of the great saphenous vein. J Vasc Surg Venous Lymphat Disord, 2020. Online ahead of print. González Cañas E, Florit López S, Vives Vilagut R, et al. A randomized controlled noninferiority trial comparing radiofrequency with stripping and conservative hemodynamic cure for venous insufficiency technique for insufficiency of the great saphenous vein. J Vasc Surg Venous Lymphat Disord, 2020. Online ahead of print.
173.
go back to reference Iborra-Ortega E, Barjau-Urrea E, Vila-Coll R, Ballón-Carazas H, Cairols-Castellote MA. Estudio comparativo de dos técnicas quirúrgicas en el tratamiento de las varices de las extremidades inferiores: resultados tras cinco años de seguimiento. Angiología. 2006;58(6):459–68. Iborra-Ortega E, Barjau-Urrea E, Vila-Coll R, Ballón-Carazas H, Cairols-Castellote MA. Estudio comparativo de dos técnicas quirúrgicas en el tratamiento de las varices de las extremidades inferiores: resultados tras cinco años de seguimiento. Angiología. 2006;58(6):459–68.
174.
go back to reference Solís JV, Ribé L, Portero JL, Rio J. Stripping saphenectomy, CHIVA, and laser ablation for the treatment of the saphenous vein insufficiency. Amb Surg. 2009;15(1):11–4. Solís JV, Ribé L, Portero JL, Rio J. Stripping saphenectomy, CHIVA, and laser ablation for the treatment of the saphenous vein insufficiency. Amb Surg. 2009;15(1):11–4.
175.
go back to reference Faccini FP, Ermini S, Franceschi C. CHIVA to treat saphenous vein insufficiency in chronic venous disease: characteristics and results. J Vasc Bras. 2019;18:e20180099.PubMedPubMedCentral Faccini FP, Ermini S, Franceschi C. CHIVA to treat saphenous vein insufficiency in chronic venous disease: characteristics and results. J Vasc Bras. 2019;18:e20180099.PubMedPubMedCentral
176.
go back to reference Milone M, Salvatore G, Maietta P, Sosa Fernandez LM, Milone F. Recurrent varicose veins of the lower limbs after surgery: role of the surgical technique (stripping vs CHIVA) and surgeon’s experience. G Chir. 2011;32(11–12):460–3.PubMed Milone M, Salvatore G, Maietta P, Sosa Fernandez LM, Milone F. Recurrent varicose veins of the lower limbs after surgery: role of the surgical technique (stripping vs CHIVA) and surgeon’s experience. G Chir. 2011;32(11–12):460–3.PubMed
177.
go back to reference Vemulapalli S, et al. Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins. Am Heart J. 2018;196:131–43.PubMed Vemulapalli S, et al. Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins. Am Heart J. 2018;196:131–43.PubMed
178.
go back to reference Van den Bos R, et al. Endovenous therapies of lower extremity varicosities: a meta-analysis. J Vasc Surg. 2009;49(1):230–9.PubMed Van den Bos R, et al. Endovenous therapies of lower extremity varicosities: a meta-analysis. J Vasc Surg. 2009;49(1):230–9.PubMed
179.
go back to reference Ahadiat O, Higgins S, Ly A, Nazemi A, Wysong A. Review of endovenous thermal ablation of the great saphenous vein. Derm Surg. 2018;44(5):679–88. Ahadiat O, Higgins S, Ly A, Nazemi A, Wysong A. Review of endovenous thermal ablation of the great saphenous vein. Derm Surg. 2018;44(5):679–88.
180.
go back to reference Paravatsu SCV, Horne M, Dodd PDF. Endovenous ablation therapy (laser or radiofrequency) or foam sclerotherapy versus conventional surgical repair for short saphenous varicose veins. Cochrane Database Syst Rev. 2016;2016(11):CD010878. Paravatsu SCV, Horne M, Dodd PDF. Endovenous ablation therapy (laser or radiofrequency) or foam sclerotherapy versus conventional surgical repair for short saphenous varicose veins. Cochrane Database Syst Rev. 2016;2016(11):CD010878.
181.
go back to reference Brittenden J, Cotton SC, Elders A, et al. Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery, and foam Sclerotherapy (CLASS) randomised controlled trial. Health Technol Assess. 2015;19(27):1–342.PubMedPubMedCentral Brittenden J, Cotton SC, Elders A, et al. Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery, and foam Sclerotherapy (CLASS) randomised controlled trial. Health Technol Assess. 2015;19(27):1–342.PubMedPubMedCentral
182.
go back to reference Nandhra S, El-sheikha J, Carradice C, et al. A randomized clinical trial of endovenous laser ablation versus conventional survey for small saphenous varicose veins. J Vasc Surg. 2015;61(3):741–6.PubMed Nandhra S, El-sheikha J, Carradice C, et al. A randomized clinical trial of endovenous laser ablation versus conventional survey for small saphenous varicose veins. J Vasc Surg. 2015;61(3):741–6.PubMed
183.
go back to reference Roopram AD, Lind MY, Van Brussel JP. Endovenous laser ablation versus conventional surgery in the treatment of small saphenous vein incompetence. J Vasc Surg Venous Lymphat Disord. 2013;1(4):357–63.PubMed Roopram AD, Lind MY, Van Brussel JP. Endovenous laser ablation versus conventional surgery in the treatment of small saphenous vein incompetence. J Vasc Surg Venous Lymphat Disord. 2013;1(4):357–63.PubMed
184.
go back to reference Darwood RJ, Theivacumar N, Dellagrammaticas D, Mavor AID, Gough MJ. Randomized clinical trial comparing endovenous laser ablation with surgery for the treatment of primary great saphenous varicose veins. Br J Surg. 2008;95(3):294–301.PubMed Darwood RJ, Theivacumar N, Dellagrammaticas D, Mavor AID, Gough MJ. Randomized clinical trial comparing endovenous laser ablation with surgery for the treatment of primary great saphenous varicose veins. Br J Surg. 2008;95(3):294–301.PubMed
185.
go back to reference Park I. Initial outcomes of endovenous laser ablation with 1940 nm diode laser in the treatment of incompetent saphenous veins. Vascular. 2019;27(1):27–32.PubMed Park I. Initial outcomes of endovenous laser ablation with 1940 nm diode laser in the treatment of incompetent saphenous veins. Vascular. 2019;27(1):27–32.PubMed
186.
go back to reference Nishibe T, Nishibe M, Suzuki S, et al. Venous hemodynamic improvement after endovenous radiofrequency ablation of saphenous varicose veins. Int Angiol. 2017;36(1):64–8.PubMed Nishibe T, Nishibe M, Suzuki S, et al. Venous hemodynamic improvement after endovenous radiofrequency ablation of saphenous varicose veins. Int Angiol. 2017;36(1):64–8.PubMed
187.
go back to reference Lurie F, et al. Prospective randomised study of endovenous radiofrequency obliteration (closure) versus ligation and vein stripping (EVOLVeS): two-year follow-up. Eur J Vasc Endovasc Surg. 2005;29(1):67–73.PubMed Lurie F, et al. Prospective randomised study of endovenous radiofrequency obliteration (closure) versus ligation and vein stripping (EVOLVeS): two-year follow-up. Eur J Vasc Endovasc Surg. 2005;29(1):67–73.PubMed
188.
go back to reference Perälä J, Rautio T, Biancari F, et al. Radiofrequency endovenous obliteration versus stripping of the long saphenous vein in the management of primary varicose veins: 3-year outcome of a randomized study. Ann Vasc Surg. 2005;19(5):669–72.PubMed Perälä J, Rautio T, Biancari F, et al. Radiofrequency endovenous obliteration versus stripping of the long saphenous vein in the management of primary varicose veins: 3-year outcome of a randomized study. Ann Vasc Surg. 2005;19(5):669–72.PubMed
189.
go back to reference Subramonia S, Lees T. Randomized clinical trial of radiofrequency ablation or conventional high ligation and stripping for great saphenous varicose veins. Br J Surg. 2010;97(3):328–36.PubMed Subramonia S, Lees T. Randomized clinical trial of radiofrequency ablation or conventional high ligation and stripping for great saphenous varicose veins. Br J Surg. 2010;97(3):328–36.PubMed
190.
go back to reference de Almeida MC, de Aruda MA, Fukuda JM, et al. Randomized trial of radiofrequency ablation versus conventional surgery for superficial venous insufficiency: if you don’t tell, they won’t know. Clinics (Sao Paulo). 2016;71(11):650–6. de Almeida MC, de Aruda MA, Fukuda JM, et al. Randomized trial of radiofrequency ablation versus conventional surgery for superficial venous insufficiency: if you don’t tell, they won’t know. Clinics (Sao Paulo). 2016;71(11):650–6.
191.
go back to reference Sincos IR, Weinhardt Baptista AP, Coelho Neto F, et al. Prospective randomized trial comparing radiofrequency ablation and complete saphenous vein stripping in patients with mild to moderate chronic venous disease with a 3-year follow-up. Einstein (Sao Paulo). 2019;17(2):eAO4526. Sincos IR, Weinhardt Baptista AP, Coelho Neto F, et al. Prospective randomized trial comparing radiofrequency ablation and complete saphenous vein stripping in patients with mild to moderate chronic venous disease with a 3-year follow-up. Einstein (Sao Paulo). 2019;17(2):eAO4526.
192.
go back to reference Nesbitt C, Bedenis R, Bhattacharya V, Stansby G. Endovenous ablation (radiofrequency and laser) and foam sclerotherapy versus open surgery for great saphenous vein varices. Cochrane Database Syst Rev. 2014;2014(7):CD005624. Nesbitt C, Bedenis R, Bhattacharya V, Stansby G. Endovenous ablation (radiofrequency and laser) and foam sclerotherapy versus open surgery for great saphenous vein varices. Cochrane Database Syst Rev. 2014;2014(7):CD005624.
193.
go back to reference ElKaffas KH, ElKashef O, ElBaz W. Great saphenous vein radiofrequency ablation versus standard stripping in the management of primary varicose veins: a randomized clinical trial. Angiology. 2011;62(1):49–54. ElKaffas KH, ElKashef O, ElBaz W. Great saphenous vein radiofrequency ablation versus standard stripping in the management of primary varicose veins: a randomized clinical trial. Angiology. 2011;62(1):49–54.
194.
go back to reference Rasmussen LH, Lawaetz M, Bjoern L, et al. Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Br J Surg. 2011;98(8):1079–87.PubMed Rasmussen LH, Lawaetz M, Bjoern L, et al. Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Br J Surg. 2011;98(8):1079–87.PubMed
195.
go back to reference Rasmussen L, Lawaetz M, Serup J, et al. Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy, and surgical stripping for great saphenous varicose veins with 3-year follow-up. J Vasc Surg Venous Lymphat Disord. 2013;1(4):349–56.PubMed Rasmussen L, Lawaetz M, Serup J, et al. Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy, and surgical stripping for great saphenous varicose veins with 3-year follow-up. J Vasc Surg Venous Lymphat Disord. 2013;1(4):349–56.PubMed
196.
go back to reference Almeida JI, Kaufman J, Göckeritz O, et al. Radiofrequency endovenous ClosureFAST versus laser ablation for the treatment of great saphenous reflux: a multicenter, single-blinded, randomized study (RECOVER study). J Vasc Interv Radiol. 2009;20(6):752–9.PubMed Almeida JI, Kaufman J, Göckeritz O, et al. Radiofrequency endovenous ClosureFAST versus laser ablation for the treatment of great saphenous reflux: a multicenter, single-blinded, randomized study (RECOVER study). J Vasc Interv Radiol. 2009;20(6):752–9.PubMed
197.
go back to reference Shepherd AC, Gohel MS, Brown LC, et al. Randomized clinical trial of VNUS ClosureFAST radiofrequency ablation versus laser for varicose veins. Br J Surg. 2010;97(6):810–8.PubMed Shepherd AC, Gohel MS, Brown LC, et al. Randomized clinical trial of VNUS ClosureFAST radiofrequency ablation versus laser for varicose veins. Br J Surg. 2010;97(6):810–8.PubMed
198.
go back to reference Gale SS, Lee JN, Walsh ME, Wojnarowski DL, Comerota AJ. A randomized, controlled trial of endovenous thermal ablation using the 810-nm wavelength laser and the ClosurePLUS radiofrequency ablation methods for superficial venous insufficiency of the great saphenous vein. J Vasc Surg. 2010;52(3):645–50.PubMed Gale SS, Lee JN, Walsh ME, Wojnarowski DL, Comerota AJ. A randomized, controlled trial of endovenous thermal ablation using the 810-nm wavelength laser and the ClosurePLUS radiofrequency ablation methods for superficial venous insufficiency of the great saphenous vein. J Vasc Surg. 2010;52(3):645–50.PubMed
199.
go back to reference Nordon IM, Hinchliffe RJ, Brar R, et al. A prospective double-blind randomized controlled trial of radiofrequency versus laser treatment of the great saphenous vein in patients with varicose veins. Ann Surg. 2011;254(6):876–81.PubMed Nordon IM, Hinchliffe RJ, Brar R, et al. A prospective double-blind randomized controlled trial of radiofrequency versus laser treatment of the great saphenous vein in patients with varicose veins. Ann Surg. 2011;254(6):876–81.PubMed
200.
go back to reference Tesmann JP, Thierbach H, Dietrich A, et al. Radiofrequency induced thermotherapy (RFITT) of varicose veins compared to endovenous laser treatment (EVLT): a non-randomized prospective study concentrating on occlusion rates, side-effects and clinical outcome. Eur J Dermatol. 2011;21(6):945–51.PubMed Tesmann JP, Thierbach H, Dietrich A, et al. Radiofrequency induced thermotherapy (RFITT) of varicose veins compared to endovenous laser treatment (EVLT): a non-randomized prospective study concentrating on occlusion rates, side-effects and clinical outcome. Eur J Dermatol. 2011;21(6):945–51.PubMed
201.
go back to reference Bozoglan O, Mese B, Eroglu E, Ekerbiçer HC, Yasim A. Comparison of endovenous laser and radiofrequency ablation in treating varices in the same patient. J Lasers Med Sci. 2017;8(1):13–6.PubMedPubMedCentral Bozoglan O, Mese B, Eroglu E, Ekerbiçer HC, Yasim A. Comparison of endovenous laser and radiofrequency ablation in treating varices in the same patient. J Lasers Med Sci. 2017;8(1):13–6.PubMedPubMedCentral
202.
go back to reference Hamann SAS, Timmer-de Mik L, Fritschy WM, et al. Randomized clinical trial of endovenous laser ablation versus direct and indirect radiofrequency ablation for the treatment of great saphenous varicose veins. Br J Surg. 2019;106(8):998–1004.PubMedPubMedCentral Hamann SAS, Timmer-de Mik L, Fritschy WM, et al. Randomized clinical trial of endovenous laser ablation versus direct and indirect radiofrequency ablation for the treatment of great saphenous varicose veins. Br J Surg. 2019;106(8):998–1004.PubMedPubMedCentral
203.
go back to reference Chait J, Kibrik P, Alsheekh A, et al. Radiofrequency ablation increases the incidence of endothermal heat-induced thrombosis. Ann Vasc Surg. 2020;62:263–7.PubMed Chait J, Kibrik P, Alsheekh A, et al. Radiofrequency ablation increases the incidence of endothermal heat-induced thrombosis. Ann Vasc Surg. 2020;62:263–7.PubMed
204.
go back to reference Lawaetz M, Serup J, Lawaetz B, et al. Comparison of endovenous ablation techniques, foam sclerotherapy and surgical stripping for great saphenous varicose veins: extended 5-year follow-up. Int Angiol. 2017;36(3):281–8.PubMed Lawaetz M, Serup J, Lawaetz B, et al. Comparison of endovenous ablation techniques, foam sclerotherapy and surgical stripping for great saphenous varicose veins: extended 5-year follow-up. Int Angiol. 2017;36(3):281–8.PubMed
205.
go back to reference Redondo P, Cabrera J. Microfoam sclerotherapy. Sem Cutan Med Surg. 2005;24(4):175–83. Redondo P, Cabrera J. Microfoam sclerotherapy. Sem Cutan Med Surg. 2005;24(4):175–83.
206.
go back to reference Labas P, Cambal M. Profuse bleeding in patients with chronic venous insufficiency. Int Angiol. 2007;26(1):64–6.PubMed Labas P, Cambal M. Profuse bleeding in patients with chronic venous insufficiency. Int Angiol. 2007;26(1):64–6.PubMed
207.
go back to reference Biemans AAM, Kockaert M, Akkersdijk GP, et al. Comparing endovenous laser ablation, foam sclerotherapy, and conventional surgery for great saphenous varicose veins. J Vasc Surg. 2013;58(3):727–34.PubMed Biemans AAM, Kockaert M, Akkersdijk GP, et al. Comparing endovenous laser ablation, foam sclerotherapy, and conventional surgery for great saphenous varicose veins. J Vasc Surg. 2013;58(3):727–34.PubMed
208.
go back to reference Shadid N, Ceulen R, Nelemans P, et al. Randomized clinical trial of ultrasound-guided foam sclerotherapy versus surgery for the incompetent great saphenous vein. Br J Surg. 2012;99(8):1062–70.PubMed Shadid N, Ceulen R, Nelemans P, et al. Randomized clinical trial of ultrasound-guided foam sclerotherapy versus surgery for the incompetent great saphenous vein. Br J Surg. 2012;99(8):1062–70.PubMed
209.
go back to reference Lattimer CR, Azzam M, Kalodiki E, et al. Cost and effectiveness of laser with phlebectomies compared with foam sclerotherapy in superficial venous insufficiency. Early results of a randomised controlled trial. Eur J Vasc Endovasc Surg. 2012;43(5):594–600.PubMed Lattimer CR, Azzam M, Kalodiki E, et al. Cost and effectiveness of laser with phlebectomies compared with foam sclerotherapy in superficial venous insufficiency. Early results of a randomised controlled trial. Eur J Vasc Endovasc Surg. 2012;43(5):594–600.PubMed
210.
go back to reference Campos W, Ohashi Torres I, Simão da Silva E, Benaduce Casella I, Puech-Leão P. A prospective randomized study comparing polidocanol foam sclerotherapy with surgical treatment of patients with primary chronic venous insufficiency and ulcer. Ann Vasc Surg. 2015;29(6):1128–35.PubMed Campos W, Ohashi Torres I, Simão da Silva E, Benaduce Casella I, Puech-Leão P. A prospective randomized study comparing polidocanol foam sclerotherapy with surgical treatment of patients with primary chronic venous insufficiency and ulcer. Ann Vasc Surg. 2015;29(6):1128–35.PubMed
211.
go back to reference van der Velden SK, Biemans AAM, De Maeseneer MGR, et al. Five-year results of a randomized clinical trial of conventional surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy in patients with great saphenous varicose veins. Br J Surg. 2015;102(10):1184–94.PubMed van der Velden SK, Biemans AAM, De Maeseneer MGR, et al. Five-year results of a randomized clinical trial of conventional surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy in patients with great saphenous varicose veins. Br J Surg. 2015;102(10):1184–94.PubMed
212.
go back to reference Figueiredo M, Araüjo S, Barros N, Miranda F. Results of surgical treatment compared with ultrasound-guided foam sclerotherapy in patients with varicose veins: a prospective randomised study. Eur J Vasc Endovasc Surg. 2009;38(6):758–63.PubMed Figueiredo M, Araüjo S, Barros N, Miranda F. Results of surgical treatment compared with ultrasound-guided foam sclerotherapy in patients with varicose veins: a prospective randomised study. Eur J Vasc Endovasc Surg. 2009;38(6):758–63.PubMed
213.
go back to reference Venermo M, Saarinen J, Eskelinen E, et al. Randomized clinical trial comparing surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy for the treatment of great saphenous varicose veins. Br J Surg. 2016;103(11):1438–44.PubMedPubMedCentral Venermo M, Saarinen J, Eskelinen E, et al. Randomized clinical trial comparing surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy for the treatment of great saphenous varicose veins. Br J Surg. 2016;103(11):1438–44.PubMedPubMedCentral
214.
go back to reference Tassie E, Scotland G, Brittenden J, et al. Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial. Br J Surg. 2014;101(12):1532–40.PubMed Tassie E, Scotland G, Brittenden J, et al. Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial. Br J Surg. 2014;101(12):1532–40.PubMed
215.
go back to reference Bountouroglou DG, Azzam M, Kakkos SK, et al. Ultrasound-guided foam sclerotherapy combined with sapheno-femoral ligation compared to surgical treatment of varicose veins: early results of a randomised controlled trial. Eur J Endovasc Surg. 2006;31(1):93–100. Bountouroglou DG, Azzam M, Kakkos SK, et al. Ultrasound-guided foam sclerotherapy combined with sapheno-femoral ligation compared to surgical treatment of varicose veins: early results of a randomised controlled trial. Eur J Endovasc Surg. 2006;31(1):93–100.
216.
go back to reference Vähäho S, Halmesmäki K, Albäck A, Saarinen E, Venermo M. Five-year follow-up of a randomized clinical trial comparing open surgery, foam sclerotherapy and endovenous laser ablation for great saphenous varicose veins. Br J Surg. 2018;105(6):686–91. Vähäho S, Halmesmäki K, Albäck A, Saarinen E, Venermo M. Five-year follow-up of a randomized clinical trial comparing open surgery, foam sclerotherapy and endovenous laser ablation for great saphenous varicose veins. Br J Surg. 2018;105(6):686–91.
217.
go back to reference Gibson K, Gunderson K. Liquid and foam sclerotherapy for spider and varicose veins. Surg Clin N Am. 2018;98(2):415–29.PubMed Gibson K, Gunderson K. Liquid and foam sclerotherapy for spider and varicose veins. Surg Clin N Am. 2018;98(2):415–29.PubMed
218.
go back to reference O’Donnell TF, Eaddy M, Raju A, et al. Assessment of thrombotic adverse events and treatment patterns associated with varicose vein treatment. J Vasc Surg Venous Lymphat Disord. 2015;3(1):27–35.PubMed O’Donnell TF, Eaddy M, Raju A, et al. Assessment of thrombotic adverse events and treatment patterns associated with varicose vein treatment. J Vasc Surg Venous Lymphat Disord. 2015;3(1):27–35.PubMed
219.
go back to reference Willenburg T, Smith PC, Shepherd A, et al. Visual disturbance following sclerotherapy for varicose veins, reticular veins and telangiectasias: a systematic literature review. Phlebology. 2013;28(3):123–31. Willenburg T, Smith PC, Shepherd A, et al. Visual disturbance following sclerotherapy for varicose veins, reticular veins and telangiectasias: a systematic literature review. Phlebology. 2013;28(3):123–31.
220.
go back to reference Hamel-Desnos C, Allaert FA. Liquid versus foam sclerotherapy. Phlebology. 2009;24(6):240–6.PubMed Hamel-Desnos C, Allaert FA. Liquid versus foam sclerotherapy. Phlebology. 2009;24(6):240–6.PubMed
221.
go back to reference Bi M, Li D, Chen Z, et al. Foam sclerotherapy compared with liquid sclerotherapy for the treatment of lower extremity varicose veins: a protocol for systematic review and meta analysis. Medicine (Baltimore). 2020;99(22):e20332. Bi M, Li D, Chen Z, et al. Foam sclerotherapy compared with liquid sclerotherapy for the treatment of lower extremity varicose veins: a protocol for systematic review and meta analysis. Medicine (Baltimore). 2020;99(22):e20332.
222.
go back to reference Kaygin MA, Halici U. Evaluation of liquid or foam sclerotherapy in small varicose veins (CEAP C1) with venous clinical severity score. Rev Assoc Med Bras (1992). 2018;64(12):1117–21. Kaygin MA, Halici U. Evaluation of liquid or foam sclerotherapy in small varicose veins (CEAP C1) with venous clinical severity score. Rev Assoc Med Bras (1992). 2018;64(12):1117–21.
223.
go back to reference Alòs J, Carreño P, López JA. Efficacy and safety of sclerotherapy using polidocanol foam: a controlled clinical trial. Eur J Vasc Endovasc Surg. 2006;31(1):101–7.PubMed Alòs J, Carreño P, López JA. Efficacy and safety of sclerotherapy using polidocanol foam: a controlled clinical trial. Eur J Vasc Endovasc Surg. 2006;31(1):101–7.PubMed
224.
go back to reference Ukritmanoroat T. Comparison of efficacy and safety between foam sclerotherapy and conventional sclerotherapy: a controlled clinical trial. J Med Assoc Thai. 2011;94(Suppl 2):S35–40.PubMed Ukritmanoroat T. Comparison of efficacy and safety between foam sclerotherapy and conventional sclerotherapy: a controlled clinical trial. J Med Assoc Thai. 2011;94(Suppl 2):S35–40.PubMed
225.
go back to reference Rabe E, Otto J, Schliephake D, Pannier F. Efficacy and safety of great saphenous vein sclerotherapy using standardised polidocanol foam (ESAF): a randomised controlled multicentre clinical trial. Eur J Vasc Endovasc Surg. 2008;35(2):238–45.PubMed Rabe E, Otto J, Schliephake D, Pannier F. Efficacy and safety of great saphenous vein sclerotherapy using standardised polidocanol foam (ESAF): a randomised controlled multicentre clinical trial. Eur J Vasc Endovasc Surg. 2008;35(2):238–45.PubMed
226.
go back to reference Ouvry P, Allaert FA, Desnos P, Hamel-Desnos C. Efficacy of polidocanol foam versus liquid in sclerotherapy of the great saphenous vein: a multicentre randomised controlled trial with a 2-year follow-up. Eur J Vasc Endovasc Surg. 2008;36(3):366–70.PubMed Ouvry P, Allaert FA, Desnos P, Hamel-Desnos C. Efficacy of polidocanol foam versus liquid in sclerotherapy of the great saphenous vein: a multicentre randomised controlled trial with a 2-year follow-up. Eur J Vasc Endovasc Surg. 2008;36(3):366–70.PubMed
227.
go back to reference Hamel-Desnos C, Desnos P, Wollmann JC, et al. Evaluation of the efficacy of polidocanol in the form of foam compared with liquid form in sclerotherapy of the greater saphenous vein: initial results. Dermatol Surg. 2003;29(12):1170–5.PubMed Hamel-Desnos C, Desnos P, Wollmann JC, et al. Evaluation of the efficacy of polidocanol in the form of foam compared with liquid form in sclerotherapy of the greater saphenous vein: initial results. Dermatol Surg. 2003;29(12):1170–5.PubMed
228.
go back to reference Uncu H. Sclerotherapy: a study comparing polidocanol in foam and liquid form. Phlebology. 2010;25(1):44–9.PubMed Uncu H. Sclerotherapy: a study comparing polidocanol in foam and liquid form. Phlebology. 2010;25(1):44–9.PubMed
229.
go back to reference Almeida JI, et al. First human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. J Vasc Surg Venous Lymphat Disord. 2013;1(2):174–80.PubMed Almeida JI, et al. First human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. J Vasc Surg Venous Lymphat Disord. 2013;1(2):174–80.PubMed
230.
go back to reference Bellam Premnath KP, Joy B, Raghavendra VA, Toms A, Sleeba T. Cyanoacrylate adhesive embolization and sclerotherapy for primary varicose veins. Phlebology. 2018;33(8):547–57.PubMed Bellam Premnath KP, Joy B, Raghavendra VA, Toms A, Sleeba T. Cyanoacrylate adhesive embolization and sclerotherapy for primary varicose veins. Phlebology. 2018;33(8):547–57.PubMed
231.
go back to reference Tok M, Tüydeş O, Yüksel A, Şenol S, Akarsu S. Early-term outcomes for treatment of saphenous vein insufficiency with n-butyl cyanoacrylate: a novel, non-thermal, and non-tumescent percutaneous embolization technique. Heart Surg Forum. 2016;19(3):E118-122.PubMed Tok M, Tüydeş O, Yüksel A, Şenol S, Akarsu S. Early-term outcomes for treatment of saphenous vein insufficiency with n-butyl cyanoacrylate: a novel, non-thermal, and non-tumescent percutaneous embolization technique. Heart Surg Forum. 2016;19(3):E118-122.PubMed
232.
go back to reference Yang GK, Parapini M, Gagnon J, Chen JC. Comparison of cyanoacrylate embolization and radiofrequency ablation for the treatment of varicose veins. Phlebology. 2019;34(4):278–83.PubMed Yang GK, Parapini M, Gagnon J, Chen JC. Comparison of cyanoacrylate embolization and radiofrequency ablation for the treatment of varicose veins. Phlebology. 2019;34(4):278–83.PubMed
233.
go back to reference Morrison N, et al. Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose). J Vasc Surg. 2015;61(4):985–94.PubMed Morrison N, et al. Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose). J Vasc Surg. 2015;61(4):985–94.PubMed
234.
go back to reference Ovalı C, Sevin MB. Twelve-month efficacy and complications of cyanoacrylate embolization compared with radiofrequency ablation for incompetent great saphenous veins. J Vasc Surg Venous Lymphat Disord. 2019;7(2):210–6.PubMed Ovalı C, Sevin MB. Twelve-month efficacy and complications of cyanoacrylate embolization compared with radiofrequency ablation for incompetent great saphenous veins. J Vasc Surg Venous Lymphat Disord. 2019;7(2):210–6.PubMed
235.
go back to reference Bademci MŞ, Kocaaslan C, Aldag M, et al. Single-center retrospective review of early outcomes of radiofrequency ablation versus cyanoacrylate ablation of isolated great saphenous vein insufficiency. J Vasc Surg Venous Lymphat Disord. 2019;7(4):480–5.PubMed Bademci MŞ, Kocaaslan C, Aldag M, et al. Single-center retrospective review of early outcomes of radiofrequency ablation versus cyanoacrylate ablation of isolated great saphenous vein insufficiency. J Vasc Surg Venous Lymphat Disord. 2019;7(4):480–5.PubMed
236.
go back to reference Ay Y, Gunes E, Turkkolu ST, et al. Comparative efficacy and life quality effects of surgical stripping, radiofrequency ablation, and cyanoacrylate embolization in patients undergoing treatment for great saphenous vein insufficiency. Phlebology. 2021;36(1):54–62.PubMed Ay Y, Gunes E, Turkkolu ST, et al. Comparative efficacy and life quality effects of surgical stripping, radiofrequency ablation, and cyanoacrylate embolization in patients undergoing treatment for great saphenous vein insufficiency. Phlebology. 2021;36(1):54–62.PubMed
237.
go back to reference Koramaz I, El Kılıç H, Gökalp F, et al. Ablation of the great saphenous vein with nontumescent n-butyl cyanoacrylate versus endovenous laser therapy. J Vasc Surg Venous Lymphat Disord. 2017;5(2):210–5.PubMed Koramaz I, El Kılıç H, Gökalp F, et al. Ablation of the great saphenous vein with nontumescent n-butyl cyanoacrylate versus endovenous laser therapy. J Vasc Surg Venous Lymphat Disord. 2017;5(2):210–5.PubMed
238.
go back to reference Çalık ES, Arslan Ü, Erkut B. Ablation therapy with cyanoacrylate glue and laser for refluxing great saphenous veins: a prospective randomised study. Vasa. 2019;48(5):405–12.PubMed Çalık ES, Arslan Ü, Erkut B. Ablation therapy with cyanoacrylate glue and laser for refluxing great saphenous veins: a prospective randomised study. Vasa. 2019;48(5):405–12.PubMed
239.
go back to reference Bissacco D, Stegher S, Calliari FM, Viani MP. Saphenous vein ablation with a new cyanoacrylate glue device: a systematic review on 1000 cases. Minim Invasive Ther Allied Technol. 2019;28(1):6–14.PubMed Bissacco D, Stegher S, Calliari FM, Viani MP. Saphenous vein ablation with a new cyanoacrylate glue device: a systematic review on 1000 cases. Minim Invasive Ther Allied Technol. 2019;28(1):6–14.PubMed
240.
go back to reference McGuinness B, Elias F, Ali KP. A comparison of duplex ultrasound findings after cyanoacrylate embolization versus endovenous laser ablation of the great saphenous vein. J Vasc Surg Venous Lymphat Disord. 2019;7(6):824–31.PubMed McGuinness B, Elias F, Ali KP. A comparison of duplex ultrasound findings after cyanoacrylate embolization versus endovenous laser ablation of the great saphenous vein. J Vasc Surg Venous Lymphat Disord. 2019;7(6):824–31.PubMed
241.
go back to reference Almeida JI, Murray SP, Romero ME. Saphenous vein histopathology 5.5 years after cyanoacrylate closure. J Vasc Surg Venous Lymphat Disord. 2020;8(2):280–4.PubMed Almeida JI, Murray SP, Romero ME. Saphenous vein histopathology 5.5 years after cyanoacrylate closure. J Vasc Surg Venous Lymphat Disord. 2020;8(2):280–4.PubMed
242.
go back to reference van Eekeren RR, et al. Endovenous mechanochemical ablation of great saphenous vein incompetence using the ClariVein device: a safety study. J Endovasc Ther. 2011;18(3):328–34.PubMed van Eekeren RR, et al. Endovenous mechanochemical ablation of great saphenous vein incompetence using the ClariVein device: a safety study. J Endovasc Ther. 2011;18(3):328–34.PubMed
244.
go back to reference Vähäaho S, Mahmoud O, Halmesmäki K, et al. Randomized clinical trial of mechanochemical and endovenous thermal ablation of great saphenous varicose veins. Br J Surg. 2019;106(5):548–54.PubMed Vähäaho S, Mahmoud O, Halmesmäki K, et al. Randomized clinical trial of mechanochemical and endovenous thermal ablation of great saphenous varicose veins. Br J Surg. 2019;106(5):548–54.PubMed
245.
go back to reference Tawfik AM, Sorour WA, El-Laboudy ME. Laser ablation versus mechanochemical ablation in the treatment of primary varicose veins: a randomized clinical trial. J Vasc Surg Venous Lymphat Disord. 2020;8(2):211–5.PubMed Tawfik AM, Sorour WA, El-Laboudy ME. Laser ablation versus mechanochemical ablation in the treatment of primary varicose veins: a randomized clinical trial. J Vasc Surg Venous Lymphat Disord. 2020;8(2):211–5.PubMed
246.
go back to reference Holewijn S, van Eekeren RRJP, Vahl A, et al. Two-year results of a multicenter randomized controlled trial comparing mechanochemical endovenous ablation to radiofrequency ablation in the treatment of primary great saphenous vein incompetence (MARADONA trial). J Vasc Surg Venous Lymphat Disord. 2019;7(3):364–74.PubMed Holewijn S, van Eekeren RRJP, Vahl A, et al. Two-year results of a multicenter randomized controlled trial comparing mechanochemical endovenous ablation to radiofrequency ablation in the treatment of primary great saphenous vein incompetence (MARADONA trial). J Vasc Surg Venous Lymphat Disord. 2019;7(3):364–74.PubMed
247.
go back to reference Bootun R, Lane TRA, Dharmarajah B, et al. Intra-procedural pain score in a randomised controlled trial comparing mechanochemical ablation to radiofrequency ablation: the multicenter Venefit™ versus ClariVein® for varicose veins trial. Phlebology. 2016;31(1):61–5.PubMed Bootun R, Lane TRA, Dharmarajah B, et al. Intra-procedural pain score in a randomised controlled trial comparing mechanochemical ablation to radiofrequency ablation: the multicenter Venefit™ versus ClariVein® for varicose veins trial. Phlebology. 2016;31(1):61–5.PubMed
248.
go back to reference Witte ME, Zeebregts CJ, de Borst GJ, Reijnen MMPJ, Boersma D. Mechanochemical endovenous ablation of saphenous veins using the ClariVein: a systematic review. Phlebology. 2017;32(10):649–57.PubMed Witte ME, Zeebregts CJ, de Borst GJ, Reijnen MMPJ, Boersma D. Mechanochemical endovenous ablation of saphenous veins using the ClariVein: a systematic review. Phlebology. 2017;32(10):649–57.PubMed
249.
go back to reference Bishawi M, Bernstein R, Boter M, et al. Mechanochemical ablation in patients with chronic venous disease: a prospective multicenter report. Phlebology. 2014;29(6):397–400.PubMed Bishawi M, Bernstein R, Boter M, et al. Mechanochemical ablation in patients with chronic venous disease: a prospective multicenter report. Phlebology. 2014;29(6):397–400.PubMed
250.
go back to reference van Eekeren RRJP, Boersma D, Holewijn S, et al. Mechanochemical endovenous ablation for the treatment of great saphenous vein insufficiency. J Vasc Surg Venous Lymphat Disord. 2014;2(3):282–8.PubMed van Eekeren RRJP, Boersma D, Holewijn S, et al. Mechanochemical endovenous ablation for the treatment of great saphenous vein insufficiency. J Vasc Surg Venous Lymphat Disord. 2014;2(3):282–8.PubMed
251.
go back to reference Elias S, Raines JK. Mechanochemical tumescentless endovenous ablation: final results of the initial clinical trials. Phlebology. 2012;27(2):67–72.PubMedPubMedCentral Elias S, Raines JK. Mechanochemical tumescentless endovenous ablation: final results of the initial clinical trials. Phlebology. 2012;27(2):67–72.PubMedPubMedCentral
252.
go back to reference Deijen CL, Schreve MA, Bosma J, et al. Clarivein mechanochemical ablation of the great and small saphenous vein: early treatment outcomes of two hospitals. Phlebology. 2016;31(3):192–7.PubMed Deijen CL, Schreve MA, Bosma J, et al. Clarivein mechanochemical ablation of the great and small saphenous vein: early treatment outcomes of two hospitals. Phlebology. 2016;31(3):192–7.PubMed
253.
go back to reference Mohamed AH, Leung C, Wallace T, et al. Mechanochemical ablation for the treatment of superficial venous incompetence: a cohort study of a single centre’s early experience. Phlebology. 2019;34(7):466–73.PubMed Mohamed AH, Leung C, Wallace T, et al. Mechanochemical ablation for the treatment of superficial venous incompetence: a cohort study of a single centre’s early experience. Phlebology. 2019;34(7):466–73.PubMed
254.
go back to reference Kim PS, Bishawi M, Draughn D, et al. Mechanochemical ablation for symptomatic great saphenous vein reflux: a two-year follow-up. Phlebology. 2017;32(1):43–8.PubMed Kim PS, Bishawi M, Draughn D, et al. Mechanochemical ablation for symptomatic great saphenous vein reflux: a two-year follow-up. Phlebology. 2017;32(1):43–8.PubMed
255.
go back to reference Witte ME, Holewijn S, van Eekeren RR. Midterm outcome of mechanochemical endovenous ablation for the treatment of great saphenous vein insufficiency. J Endovasc Ther. 2017;24(1):149–55.PubMed Witte ME, Holewijn S, van Eekeren RR. Midterm outcome of mechanochemical endovenous ablation for the treatment of great saphenous vein insufficiency. J Endovasc Ther. 2017;24(1):149–55.PubMed
Metadata
Title
Management of Lower Extremity Pain from Chronic Venous Insufficiency: A Comprehensive Review
Authors
Vwaire Orhurhu
Robert Chu
Katherine Xie
Ghislain N. Kamanyi
Bisola Salisu
Mariam Salisu-Orhurhu
Ivan Urits
Rachel J. Kaye
Jamal Hasoon
Omar Viswanath
Aaron J. Kaye
Jay Karri
Zwade Marshall
Alan D. Kaye
Dua Anahita
Publication date
01-06-2021
Publisher
Springer Healthcare
Published in
Cardiology and Therapy / Issue 1/2021
Print ISSN: 2193-8261
Electronic ISSN: 2193-6544
DOI
https://doi.org/10.1007/s40119-021-00213-x

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