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Published in: Intensive Care Medicine 8/2007

01-08-2007 | Original

Variability in outcome and resource use in intensive care units

Authors: Hans U. Rothen, Kay Stricker, Johanna Einfalt, Peter Bauer, Philip G. H. Metnitz, Rui P. Moreno, Jukka Takala

Published in: Intensive Care Medicine | Issue 8/2007

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Abstract

Objective

To examine variability in outcome and resource use between ICUs. Secondary aims: to assess whether outcome and resource use are related to ICU structure and process, to explore factors associated with efficient resource use.

Design and setting

Cohort study, based on the SAPS 3 database in 275 ICUs worldwide.

Patients

16,560 adults.

Measurements and results

Outcome was defined by standardized mortality rate (SMR). Standardized resource use (SRU) was calculated based on length of stay in the ICU, adjusted for severity of acute illness. Each unit was assigned to one of four groups: “most efficient” (SMR and SRU < median); “least efficient” (SMR, SRU > median); “overachieving” (low SMR, high SRU), “underachieving” (high SMR, low SRU). Univariate analysis and stepwise logistic regression were used to test for factors separating “most” from “least efficient” units. Overall median SMR was 1.00 (IQR 0.77–1.28) and SRU 1.07 (0.76–1.58). There were 91 “most efficient”, 91 “least efficient”, 47 “overachieving”, and 46 “underachieving” ICUs. Number of physicians, of full-time specialists, and of nurses per bed, clinical rounds, availability of physicians, presence of emergency department, and geographical region were significant in univariate analysis. In multivariate analysis only interprofessional rounds, emergency department, and geographical region entered the model as significant.

Conclusions

Despite considerable variability in outcome and resource use only few factors of ICU structure and process were associated with efficient use of ICU. This suggests that other confounding factors play an important role.
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Literature
1.
2.
go back to reference Lassnigg A, Hiesmayr MJ, Bauer P, Haisjackl M (2002) Effect of centre-, patient- and procedure-related factors on intensive care resource utilisation after cardiac surgery. Intensive Care Med 28:1453–1461PubMedCrossRef Lassnigg A, Hiesmayr MJ, Bauer P, Haisjackl M (2002) Effect of centre-, patient- and procedure-related factors on intensive care resource utilisation after cardiac surgery. Intensive Care Med 28:1453–1461PubMedCrossRef
3.
go back to reference Niskanen MM, Takala J (2001) Use of resources and postoperative outcome. Eur J Surg 167:643–649PubMedCrossRef Niskanen MM, Takala J (2001) Use of resources and postoperative outcome. Eur J Surg 167:643–649PubMedCrossRef
4.
go back to reference Pollack MM, Patel KM (2002) Need for shift in focus in research into quality of intensive care. Lancet 359:95–96PubMedCrossRef Pollack MM, Patel KM (2002) Need for shift in focus in research into quality of intensive care. Lancet 359:95–96PubMedCrossRef
5.
go back to reference Suter PM (2005) Some ICUs save more lives than others: we need to know why! Intensive Care Med 31:1301–1302PubMedCrossRef Suter PM (2005) Some ICUs save more lives than others: we need to know why! Intensive Care Med 31:1301–1302PubMedCrossRef
6.
go back to reference Amaravadi RK, Dimick JB, Pronovost PJ, Lipsett PA (2000) ICU nurse-to-patient ratio is associated with complications and resource use after esophagectomy. Intensive Care Med 26:1857–1862PubMedCrossRef Amaravadi RK, Dimick JB, Pronovost PJ, Lipsett PA (2000) ICU nurse-to-patient ratio is associated with complications and resource use after esophagectomy. Intensive Care Med 26:1857–1862PubMedCrossRef
7.
go back to reference Pronovost PJ, Dang D, Dorman T, Lipsett PA, Garrett E, Jenckes M, Bass EB (2001) Intensive care unit nurse staffing and the risk for complications after abdominal aortic surgery. Eff Clin Pract 4:199–206PubMed Pronovost PJ, Dang D, Dorman T, Lipsett PA, Garrett E, Jenckes M, Bass EB (2001) Intensive care unit nurse staffing and the risk for complications after abdominal aortic surgery. Eff Clin Pract 4:199–206PubMed
8.
go back to reference Metnitz PG, Lang T, Vesely H, Valentin A, Le Gall JR (2000) Ratios of observed to expected mortality are affected by differences in case mix and quality of care. Intensive Care Med 26:1466–1472PubMedCrossRef Metnitz PG, Lang T, Vesely H, Valentin A, Le Gall JR (2000) Ratios of observed to expected mortality are affected by differences in case mix and quality of care. Intensive Care Med 26:1466–1472PubMedCrossRef
9.
go back to reference Tucker J (2002) Patient volume, staffing, and workload in relation to risk-adjusted outcomes in a random stratified sample of UK neonatal intensive care units: a prospective evaluation. Lancet 359:99–107PubMedCrossRef Tucker J (2002) Patient volume, staffing, and workload in relation to risk-adjusted outcomes in a random stratified sample of UK neonatal intensive care units: a prospective evaluation. Lancet 359:99–107PubMedCrossRef
10.
go back to reference Iapichino G, Gattinoni L, Radrizzani D, Simini B, Bertolini G, Ferla L, Mistraletti G, Porta F, Miranda DR (2004) Volume of activity and occupancy rate in intensive care units. Association with mortality. Intensive Care Med 30:290–297PubMedCrossRef Iapichino G, Gattinoni L, Radrizzani D, Simini B, Bertolini G, Ferla L, Mistraletti G, Porta F, Miranda DR (2004) Volume of activity and occupancy rate in intensive care units. Association with mortality. Intensive Care Med 30:290–297PubMedCrossRef
11.
go back to reference Kahn JM, Goss CH, Heagerty PJ, Kramer AA, O'Brien CR, Rubenfeld GD (2006) Hospital volume and the outcomes of mechanical ventilation. N Engl J Med 355:41–50PubMedCrossRef Kahn JM, Goss CH, Heagerty PJ, Kramer AA, O'Brien CR, Rubenfeld GD (2006) Hospital volume and the outcomes of mechanical ventilation. N Engl J Med 355:41–50PubMedCrossRef
12.
go back to reference Glance LG, Li Y, Osler TM, Dick A, Mukamel DB (2006) Impact of patient volume on the mortality rate of adult intensive care unit patients. Crit Care Med 34:1925–1934PubMedCrossRef Glance LG, Li Y, Osler TM, Dick A, Mukamel DB (2006) Impact of patient volume on the mortality rate of adult intensive care unit patients. Crit Care Med 34:1925–1934PubMedCrossRef
13.
go back to reference Metnitz PG, Moreno RP, Almeida E, Jordan B, Bauer P, Campos RA, Iapichino G, Edbrooke D, Capuzzo M, Le Gall JR (2005) SAPS 3—from evaluation of the patient to evaluation of the intensive care unit. I. Objectives, methods and cohort description. Intensive Care Med 31:1336–1344PubMedCrossRef Metnitz PG, Moreno RP, Almeida E, Jordan B, Bauer P, Campos RA, Iapichino G, Edbrooke D, Capuzzo M, Le Gall JR (2005) SAPS 3—from evaluation of the patient to evaluation of the intensive care unit. I. Objectives, methods and cohort description. Intensive Care Med 31:1336–1344PubMedCrossRef
14.
go back to reference Moreno RP, Metnitz PG, Almeida E, Jordan B, Bauer P, Campos RA, Iapichino G, Edbrooke D, Capuzzo M, Le Gall JR (2005) SAPS 3—from evaluation of the patient to evaluation of the intensive care unit. II. Development of a prognostic model for hospital mortality at ICU admission. Intensive Care Med 31:1345–1355PubMedCrossRef Moreno RP, Metnitz PG, Almeida E, Jordan B, Bauer P, Campos RA, Iapichino G, Edbrooke D, Capuzzo M, Le Gall JR (2005) SAPS 3—from evaluation of the patient to evaluation of the intensive care unit. II. Development of a prognostic model for hospital mortality at ICU admission. Intensive Care Med 31:1345–1355PubMedCrossRef
15.
go back to reference Rothen HU, Stricker KH, Einfalt J, Metnitz PG, Moreno RP, Takala J (2006) Variability in outcome and resource use in ICU's. Intensive Care Med 32(Suppl 1):S138 Rothen HU, Stricker KH, Einfalt J, Metnitz PG, Moreno RP, Takala J (2006) Variability in outcome and resource use in ICU's. Intensive Care Med 32(Suppl 1):S138
16.
go back to reference Rapoport J, Teres D, Lemeshow S, Gehlbach S (1994) A method for assessing the clinical performance and cost-effectiveness of intensive care units: a multicenter inception cohort study. Crit Care Med 22:1385–1391PubMedCrossRef Rapoport J, Teres D, Lemeshow S, Gehlbach S (1994) A method for assessing the clinical performance and cost-effectiveness of intensive care units: a multicenter inception cohort study. Crit Care Med 22:1385–1391PubMedCrossRef
17.
go back to reference Katz MH (2003) Multivariable analysis: a primer for readers of medical research. Ann Intern Med 138:644–650PubMed Katz MH (2003) Multivariable analysis: a primer for readers of medical research. Ann Intern Med 138:644–650PubMed
19.
go back to reference Sirio CA, Shepardson LB, Rotondi AJ, Cooper GS, Angus DC, Harper DL, Rosenthal GE (1999) Community-wide assessment of intensive care outcomes using a physiologically based prognostic measure: implications for critical care delivery from Cleveland Health Quality Choice. Chest 115:793–801PubMedCrossRef Sirio CA, Shepardson LB, Rotondi AJ, Cooper GS, Angus DC, Harper DL, Rosenthal GE (1999) Community-wide assessment of intensive care outcomes using a physiologically based prognostic measure: implications for critical care delivery from Cleveland Health Quality Choice. Chest 115:793–801PubMedCrossRef
20.
go back to reference Kaboli PJ, Barnett MJ, Fuehrer SM, Rosenthal GE (2001) Length of stay as a source of bias in comparing performance in VA and private sector facilities: lessons learned from a regional evaluation of intensive care outcomes. Med Care 39:1014–1024PubMedCrossRef Kaboli PJ, Barnett MJ, Fuehrer SM, Rosenthal GE (2001) Length of stay as a source of bias in comparing performance in VA and private sector facilities: lessons learned from a regional evaluation of intensive care outcomes. Med Care 39:1014–1024PubMedCrossRef
21.
go back to reference Jegers M, Edbrooke DL, Hibbert CL, Chalfin DB, Burchardi H (2002) Definitions and methods of cost assessment: an intensivist's guide. Intensive Care Med 28:680–685PubMedCrossRef Jegers M, Edbrooke DL, Hibbert CL, Chalfin DB, Burchardi H (2002) Definitions and methods of cost assessment: an intensivist's guide. Intensive Care Med 28:680–685PubMedCrossRef
22.
go back to reference Negrini D, Sheppard L, Mills GH, Jacobs P, Rapoport J, Bourne RS, Guidet B, Csomos A, Prien T, Anderson G, Edbrooke DL (2006) International Programme for Resource Use in Critical Care (IPOC)—a methodology and initial results of cost and provision in four European countries. Acta Anaesthesiol Scand 50:72–79PubMedCrossRef Negrini D, Sheppard L, Mills GH, Jacobs P, Rapoport J, Bourne RS, Guidet B, Csomos A, Prien T, Anderson G, Edbrooke DL (2006) International Programme for Resource Use in Critical Care (IPOC)—a methodology and initial results of cost and provision in four European countries. Acta Anaesthesiol Scand 50:72–79PubMedCrossRef
23.
go back to reference Pronovost PJ, Needham DM, Waters H, Birkmeyer CM, Calinawan JR, Birkmeyer JD, Dorman T (2006) Intensive care unit physician staffing: financial modelling of the Leapfrog standard. Crit Care Med 34(Suppl 3):S18–S24PubMedCrossRef Pronovost PJ, Needham DM, Waters H, Birkmeyer CM, Calinawan JR, Birkmeyer JD, Dorman T (2006) Intensive care unit physician staffing: financial modelling of the Leapfrog standard. Crit Care Med 34(Suppl 3):S18–S24PubMedCrossRef
24.
go back to reference Clermont G, Angus DC, Linde-Zwirble WT, Lave JR, Pinsky MR (1998) Measuring resource use in the ICU with computerized therapeutic intervention scoring system-based data. Chest 113:434–442PubMed Clermont G, Angus DC, Linde-Zwirble WT, Lave JR, Pinsky MR (1998) Measuring resource use in the ICU with computerized therapeutic intervention scoring system-based data. Chest 113:434–442PubMed
25.
go back to reference Stricker K, Rothen HU, Takala J (2003) Resource use in the ICU: short- vs. long-term patients. Acta Anaesthesiol Scand 47:508–515PubMedCrossRef Stricker K, Rothen HU, Takala J (2003) Resource use in the ICU: short- vs. long-term patients. Acta Anaesthesiol Scand 47:508–515PubMedCrossRef
26.
go back to reference Angus DC, Linde-Zwirble WT, Sirio CA, Rotondi AJ, Chelluri L, Newbold RC 3rd, Lave JR, Pinsky MR (1996) The effect of managed care on ICU length of stay: implications for medicare. JAMA 276:1075–1082PubMedCrossRef Angus DC, Linde-Zwirble WT, Sirio CA, Rotondi AJ, Chelluri L, Newbold RC 3rd, Lave JR, Pinsky MR (1996) The effect of managed care on ICU length of stay: implications for medicare. JAMA 276:1075–1082PubMedCrossRef
27.
go back to reference Rapoport J, Teres D, Zhao Y, Lemeshow S (2003) Length of stay data as a guide to hospital economic performance for ICU patients. Med Care 41:386–397PubMedCrossRef Rapoport J, Teres D, Zhao Y, Lemeshow S (2003) Length of stay data as a guide to hospital economic performance for ICU patients. Med Care 41:386–397PubMedCrossRef
28.
go back to reference Iapichino G, Radrizzani D, Bertolini G, Ferla L, Pasetti G, Pezzi A, Porta F, Miranda DR (2001) Daily classification of the level of care. A method to describe clinical course of illness, use of resources and quality of intensive care assistance. Intensive Care Med 27:131–136PubMedCrossRef Iapichino G, Radrizzani D, Bertolini G, Ferla L, Pasetti G, Pezzi A, Porta F, Miranda DR (2001) Daily classification of the level of care. A method to describe clinical course of illness, use of resources and quality of intensive care assistance. Intensive Care Med 27:131–136PubMedCrossRef
29.
go back to reference Rosenthal GE, Harper DL, Quinn LM, Cooper GS (1997) Severity-adjusted mortality and length of stay in teaching and nonteaching hospitals. Results of a regional study. JAMA 278:485–490PubMedCrossRef Rosenthal GE, Harper DL, Quinn LM, Cooper GS (1997) Severity-adjusted mortality and length of stay in teaching and nonteaching hospitals. Results of a regional study. JAMA 278:485–490PubMedCrossRef
30.
go back to reference Render ML, Kim HM, Deddens J, Sivaganesin S, Welsh DE, Bickel K, Freyberg R, Timmons S, Johnston J, Connors AF Jr, Wagner D, Hofer TP (2005) Variation in outcomes in Veterans Affairs intensive care units with a computerized severity measure. Crit Care Med 33:930–939PubMedCrossRef Render ML, Kim HM, Deddens J, Sivaganesin S, Welsh DE, Bickel K, Freyberg R, Timmons S, Johnston J, Connors AF Jr, Wagner D, Hofer TP (2005) Variation in outcomes in Veterans Affairs intensive care units with a computerized severity measure. Crit Care Med 33:930–939PubMedCrossRef
31.
go back to reference Zimmerman JE, Kramer AA, McNair DS, Malila FM, Shaffer VL (2006) Intensive care unit length of stay: benchmarking based on Acute Physiology and Chronic Health Evaluation (APACHE) IV. Crit Care Med 34:2517–2529PubMedCrossRef Zimmerman JE, Kramer AA, McNair DS, Malila FM, Shaffer VL (2006) Intensive care unit length of stay: benchmarking based on Acute Physiology and Chronic Health Evaluation (APACHE) IV. Crit Care Med 34:2517–2529PubMedCrossRef
32.
go back to reference Thorens JB, Kaelin RM, Jolliet P, Chevrolet JC (1995) Influence of the quality of nursing on the duration of weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease. Crit Care Med 23:1807–1815PubMedCrossRef Thorens JB, Kaelin RM, Jolliet P, Chevrolet JC (1995) Influence of the quality of nursing on the duration of weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease. Crit Care Med 23:1807–1815PubMedCrossRef
33.
go back to reference Pronovost PJ, Angus DC, Dorman T, Robinson KA, Dremsizov TT, Young TL (2002) Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA 288:2151–2162PubMedCrossRef Pronovost PJ, Angus DC, Dorman T, Robinson KA, Dremsizov TT, Young TL (2002) Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA 288:2151–2162PubMedCrossRef
34.
go back to reference Dara SI, Afessa B (2005) Intensivist-to-bed ratio: association with outcomes in the medical ICU. Chest 128:567–572PubMedCrossRef Dara SI, Afessa B (2005) Intensivist-to-bed ratio: association with outcomes in the medical ICU. Chest 128:567–572PubMedCrossRef
35.
go back to reference Durairaj L, Torner JC, Chrischilles EA, Vaughan Sarrazin MS, Yankey J, Rosenthal GE (2005) Hospital volume-outcome relationships among medical admissions to ICUs. Chest 128:1682–1689PubMedCrossRef Durairaj L, Torner JC, Chrischilles EA, Vaughan Sarrazin MS, Yankey J, Rosenthal GE (2005) Hospital volume-outcome relationships among medical admissions to ICUs. Chest 128:1682–1689PubMedCrossRef
36.
go back to reference Carson SS, Stocking C, Podsadecki T, Christenson J, Pohlman A, MacRae S, Jordan J, Humphrey H, Siegler M, Hall J (1996) Effects of organizational change in the medical intensive care unit of a teaching hospital: a comparison of ‘open’ and ‘closed’ formats. JAMA 276:322–328PubMedCrossRef Carson SS, Stocking C, Podsadecki T, Christenson J, Pohlman A, MacRae S, Jordan J, Humphrey H, Siegler M, Hall J (1996) Effects of organizational change in the medical intensive care unit of a teaching hospital: a comparison of ‘open’ and ‘closed’ formats. JAMA 276:322–328PubMedCrossRef
37.
go back to reference Baggs JG, Schmitt MH, Mushlin AI, Mitchell PH, Eldredge DH, Oakes D, Hutson AD (1999) Association between nurse-physician collaboration and patient outcomes in three intensive care units. Crit Care Med 27:1991–1998PubMedCrossRef Baggs JG, Schmitt MH, Mushlin AI, Mitchell PH, Eldredge DH, Oakes D, Hutson AD (1999) Association between nurse-physician collaboration and patient outcomes in three intensive care units. Crit Care Med 27:1991–1998PubMedCrossRef
38.
go back to reference Barrett H, Bion JF (2005) An international survey of training in adult intensive care medicine. Intensive Care Med 31:553–561PubMedCrossRef Barrett H, Bion JF (2005) An international survey of training in adult intensive care medicine. Intensive Care Med 31:553–561PubMedCrossRef
39.
go back to reference Thomas JW, Hofer TP (1999) Accuracy of risk-adjusted mortality rate as a measure of hospital quality of care. Med Care 37:83–92PubMedCrossRef Thomas JW, Hofer TP (1999) Accuracy of risk-adjusted mortality rate as a measure of hospital quality of care. Med Care 37:83–92PubMedCrossRef
40.
go back to reference Pronovost PJ, Nolan T, Zeger S, Miller M, Rubin H (2004) How can clinicians measure safety and quality in acute care? Lancet 363:1061–1067PubMedCrossRef Pronovost PJ, Nolan T, Zeger S, Miller M, Rubin H (2004) How can clinicians measure safety and quality in acute care? Lancet 363:1061–1067PubMedCrossRef
Metadata
Title
Variability in outcome and resource use in intensive care units
Authors
Hans U. Rothen
Kay Stricker
Johanna Einfalt
Peter Bauer
Philip G. H. Metnitz
Rui P. Moreno
Jukka Takala
Publication date
01-08-2007
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 8/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0690-3

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