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Supportive Care in Cancer

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01-12-2012 | Original Article

Utility of peripheral blood cultures in patients with cancer and suspected blood stream infections: a systematic review

Authors: Laura Rodríguez, Marie-Chantal Ethier, Bob Phillips, Thomas Lehrnbecher, John Doyle, Lillian Sung

Published in: Supportive Care in Cancer | Issue 12/2012

Abstract

Purpose

The utility of peripheral blood cultures in patients with cancer and/or hematopoietic stem cell transplantation (HSCT) recipients with central venous lines (CVL) and suspected blood stream infection (BSI) is controversial. Our main objective was to describe the proportion of bacteremia detected only by the peripheral blood (PB) culture in order to define its role in the evaluation of patients in this setting.

Methods

We performed electronic searches of OVID Medline, EMBASE, and the Cochrane Central Register of Controlled Trials for studies of adults or children with cancer and/or HSCT that evaluated concurrent PB and CVL cultures and reported sufficient data to permit calculation of the primary outcome. The proportion of bacteremia identified by site of sample was used as the effect measure. The review was registered in PROSPERO: CRD42011001610.

Results

From 149 reviewed articles, 7 were included in the meta-analysis. In a total number of 10,370 paired blood cultures, bacteremia was detected in 17 %. Thirteen percent of BSI were only identified by PB, while 28 % of infections were only identified by CVL.

Conclusions

PB cultures identified many episodes of bacteremia not detected in the CVL culture. This finding suggests that PB culture should be considered in the evaluation of patients with cancer and/or HSCT with suspected BSI.

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Title: Utility of peripheral blood cultures in patients with cancer and suspected blood stream infections: a systematic review
Authors: Laura Rodríguez
Marie-Chantal Ethier
Bob Phillips
Thomas Lehrnbecher
John Doyle
Lillian Sung
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Supportive Care in Cancer / Issue 12/2012
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-012-1471-2

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Abstract

Purpose

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Conclusions

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