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Current Rheumatology Reports

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01-12-2019 | Ustekinumab | Psoriatic Arthritis (JU Scher, Section Editor)

Psoriatic Arthritis: Newer and Older Therapies

Authors: Robert Chao, Arthur Kavanaugh

Published in: Current Rheumatology Reports | Issue 12/2019

Abstract

Purpose of Review

Psoriatic arthritis (PsA) is an immune-mediated systemic inflammatory disorder with heterogeneous clinical features. Treatment for PsA has progressed rapidly, especially over the past two decades. Herein we review relevant studies and key developments in treatment options for PsA from the past 5 years.

Recent Findings

Conventional disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate showed some efficacy for several domains of PsA, albeit less than that achieved with TNF inhibitors (TNFi). TNFi have been shown to be efficacious in treatment across all domains of PsA, particularly preventing radiographic damage, and are highly efficient early in the disease course. Inhibitors of IL-12/23, IL-17A, IL-23, phosphodiesterase 4, T cell costimulation, and janus kinases (JAK) have proven efficacious in the treatment of peripheral arthritis of PsA patients. The introduction of biosimilars to TNFi is expected to impact the treatment algorithm for PsA treatment by increasing access to biologic drugs. Newer treatment modalities including IL-23-specific inhibitors, IL-17A and IL-17F dual inhibitors, and jakinibs (janus kinase inhibitors) with different specificity are currently being developed for treatment of PsA.

Summary

The recent development of new therapeutic agents for PsA has led to better control of PsA across all of its disease domains. The future of PsA management will likely usher in treatment with different mechanisms of action, allow for more access to care, and hopefully see the possibility of precision medicine to help select the optimal treatment approach for individual PsA patients.

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Title: Psoriatic Arthritis: Newer and Older Therapies
Authors: Robert Chao
Arthur Kavanaugh
Publication date: 01-12-2019
Publisher: Springer US
Keywords: Ustekinumab
Disease Modifying Anti-Rheumatic Drug
TNF-Inhibitors
Arthritis
Methotrexate
Vulgar Psoriasis
Methotrexate
Psoriatic Arthritis
Secukinumab
Golimumab
Ixekizumab
Published in: Current Rheumatology Reports / Issue 12/2019
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-019-0866-1

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Recent Findings

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