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Keynote webinar | Spotlight on medication adherence

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Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
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Clinical Rheumatology
Published in: Clinical Rheumatology 9/2008

01-09-2008 | Editorial

Use of nonsteroidal anti-inflammatory drugs and coxibs in the elderly. Are we following the guidelines?

Authors: Sergio Duran-Barragan, Anthony S. Russell

Published in: Clinical Rheumatology | Issue 9/2008

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Excerpt

Selective (coxibs) and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are an effective group of drugs commonly prescribed for rheumatic diseases, e.g., osteoarthritis and rheumatoid arthritis [1]. Inappropriate medication use is a major patient safety concern, especially for an elderly population [2]. The third Canadian Consensus Conference was convened to revise the evidence-based recommendations for the use of NSAIDs and coxibs, and while reviewing their general effectiveness and safety, reemphasized major concerns about their use in the elderly population [3]. …
Literature
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Chen YF, Jobanputra P, Barton P et al (2008) Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. Health Technol Assess 12:1–178PubMed
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Abraham NS, El-Serag HB, Johnson ML et al (2005) National adherence to evidence-based guidelines for the prescription of nonsteroidal anti-inflammatory drugs. Gastroenterology 129:1171–1178PubMedCrossRef
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Tannenbaum H, Bombardier C, Davis P et al (2006) An evidence-based approach to prescribing nonsteroidal anti-inflammatory drugs. Third Canadian Consensus Conference. J Rheumatol 33:140–157PubMed
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McLean AJ, Le Couteur DG (2004) Aging biology and geriatric clinical pharmacology. Pharmacol Rev 56:163–184PubMedCrossRef
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Skeith KJ, Wright M, Davis P (1994) Differences in NSAID tolerability profiles. Fact or fiction? Drug Saf 10:183–195PubMedCrossRef
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Rahme E, Barkun A, Nedjar H et al (2008) Hospitalizations for upper and lower GI events associated with traditional NSAIDs and acetaminophen among the elderly in Quebec, Canada. Am J Gastroenterol 103:872–882PubMedCrossRef
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Zhan C, Sangl J, Bierman AS et al (2001) Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel Survey. JAMA 286:2823–2829PubMedCrossRef
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Visser LE, Graatsma HH, Stricker BH (2002) Contraindicated NSAIDs are frequently prescribed to elderly patients with peptic ulcer disease. Br J Clin Pharmacol 53:183–188PubMedCrossRef
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Rochon PA, Lane CJ, Bronskill SE et al (2004) Potentially inappropriate prescribing in Canada relative to the US. Drugs Aging 21:939–947PubMedCrossRef
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Metadata
Title
Use of nonsteroidal anti-inflammatory drugs and coxibs in the elderly. Are we following the guidelines?
Authors
Sergio Duran-Barragan
Anthony S. Russell
Publication date
01-09-2008
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue 9/2008
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-008-0959-0

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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