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Child's Nervous System

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01-08-2005 | Special Annual Issue

Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma

Authors: S. Cavalheiro, P. A. Dastoli, N. S. Silva, S. Toledo, H. Lederman, M. C. da Silva

Published in: Child's Nervous System | Issue 8-9/2005

Abstract

Objectives

This study analyzed the intratumoral activity of interferon alpha (IFN-α) in the treatment of cystic craniopharyngiomas.

Patients and methods

From January 2000 to January 2004, nine patients presenting with cystic craniopharyngiomas were treated with intratumoral injection of IFN-α at the Pediatric Oncology Institute of the Federal University of São Paulo–Escola Paulista de Medicina. Age ranged from 1 year and 10 months to 18 years (mean 10 years). All intratumoral catheters were inserted by a subfrontal approach. Doses varied from 36 to 108 MU.

Results

There was complete disappearance of the lesion in seven cases. In two cases, partial reduction of tumor size was observed at follow-up. Follow-up varied from 1 year to 3 years and 6 months (mean 1 year 8 months).

Conclusions

IFN-α proved to be an effective drug in the control of cystic craniopharyngiomas. Additional studies should be carried out to determine the optimal dose of IFN-α in the treatment of cystic craniopharyngioma. In addition, other drugs possessing high efficacy and low neurotoxicity should be analyzed.

Carmel PW (1990) Tumours of disordered embryogenesis. In: Youmans JR (ed) Neurological surgery, 3rd edn. WB Saunders, Philadelphia, pp 3223–3249

Cavalheiro S, Sparapani FVC, Franco JOB, Da Silva MC, Braga FM (1996) Use of bleomycin in intratumoral chemotherapy for cystic craniopharyngioma. J Neurosurg 84:124–126

Chamberlain MC (2002) A phase II trial of intra-cerebrospinal fluid alpha interferon in the treatment of neoplastic meningitis. Cancer 94:2675–2680CrossRefPubMed

Chawla-Sarkar M, Lindner DJ, Liu YF, Williams BR, Sen GC, Silverman RH, Borden EC (2003) Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 8:237–249CrossRefPubMed

Choux M, Lena G, Genitori L (1991) Le craniopharyngiome de l’enfant. Neurochirurgie 37:113–128

Gutterman JU (1994) Cytokine therapeutics: lessons from interferon α. Proc Natl Acad Sci U S A 99:1198–1205

Jakacki RI, Cohen BH, Jamison C, Mathews VP, Arenson E, Longee DC, Hilden J, Cornelius AL, Needle M, Heilman D, Boaz JC, Luerssen TG (2000) Phase II evaluation of interferon-α-2a for progressive or recurrent craniopharyngiomas. J Neurosurg 92:255–260PubMed

Laws ER Jr (1994) Transsphenoidal removal of craniopharyngioma. Pediatr Neurosurg 21(Suppl 1):57–63PubMed

Muhr C, Gudjonsson O, Lilja A, Hartman M, Zhang Z, Langströn B (2001) Meningioma treated with interferon-α, evaluated with [11C]-l-methionine positron emission tomography. Clin Cancer Res 7:2269–2276PubMed

10.

Russel DS, Rubinstein LJ (1989) Pathology of tumours of the nervous system, 5th edn. Edward Arnold, London, p 695

11.

Savas A, Erdem A, Tun K, Yücel K (2000) Fatal toxic effect of bleomycin on brain tissue after intracystic chemotherapy for a craniopharyngioma: case report. Neurosurgery 46:213–217

12.

Selleri C, Sato T, Del Vecchio L, Luciano L, Barret Aj, Rotoli B, Young NS, Maciejewski JP (1997) Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-α in chronic myelogenous leukemia. Blood 89:957–964PubMed

13.

Symon L (1994) An approach to radical excision of craniopharyngioma in children. Pediatr Neurosurg 21(Suppl):64–68PubMed

14.

Tagliaferri P, Caraglia M, Budilon A, Marra M, Vitali G, Viscomi C, Masciari S, Tassone P, Abbruzzese A, Venuta S (2005) New pharmacokinetic and pharmacodynamic tools for interferon-alpha (IFN-α) treatment of human cancer. Cancer Immunol Immunother 54:1–10CrossRefPubMed

15.

Takahashi H, Nakazawa S, Shimura T (1985) Evaluation of postoperative intratumoral injection of bleomycin for craniopharyngioma in children. J Neurosurg 62:120–127

16.

Takeuchi K (1976) Effect of bleomycin on brain tumors. In: Carter SK, Ichikawa T, Mathe G et al (eds) Fundamental and clinical studies of bleomycin. Gann monograph on cancer research, No. 19. Japan Scientific Societies Press, Tokyo, pp 117–132

17.

Wisoff JH (1994) Surgical management of recurrent craniopharyngiomas. Pediatr Neurosurg 21(Suppl 1):108–113PubMed

Title: Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma
Authors: S. Cavalheiro
P. A. Dastoli
N. S. Silva
S. Toledo
H. Lederman
M. C. da Silva
Publication date: 01-08-2005
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 8-9/2005
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-005-1226-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma

Abstract

Objectives

Patients and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Patients and methods

Results

Conclusions

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