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Published in: International Orthopaedics 9/2011

Open Access 01-09-2011 | Review

Use and efficacy of bone morphogenetic proteins in fracture healing

Authors: Suzanne N. Lissenberg-Thunnissen, David J. J. de Gorter, Cornelis F. M. Sier, Inger B. Schipper

Published in: International Orthopaedics | Issue 9/2011

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Abstract

Purpose

This review evaluates the application of bone morphogenetic proteins (BMPs) in delayed bone repair, aiming at a broad audience from clinicians to scientists. Next to an overview of the role of the different BMPs, their antagonists and their current applications, special attention is focused on new scientific developments improving the effects of BMP-based therapy for bone repair.

Methods

Publication searches in PubMed and Embase revealed 850 relevant articles on the criteria ‘BMP’ AND ‘bone repair’ (as of May 2011). The abstracts were carefully reviewed and papers were selected according to the content.

Results

The resulting publications showed that BMP-2 and BMP-7 are clearly the most extensively evaluated BMPs, in general with positive results on bone healing, comparable to the use of unspecific preparations such as autologous bone grafts or platelet-rich plasma.

Conclusions

Although the efficacy of BMPs as stimulators of bone repair has been demonstrated in model systems and clinical studies, the use of BMPs to enhance fracture healing in the clinical setting is still controversial. Issues such as when, where and how much of which BMP is the most effective and profitable to use still have to be elucidated. But optimisation of the BMP products used in combination with cheaper production methods will inevitably stimulate the clinical use of BMPs for bone fracture healing in the near future.
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Metadata
Title
Use and efficacy of bone morphogenetic proteins in fracture healing
Authors
Suzanne N. Lissenberg-Thunnissen
David J. J. de Gorter
Cornelis F. M. Sier
Inger B. Schipper
Publication date
01-09-2011
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 9/2011
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-011-1301-z

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