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01-08-2009 | Original Paper

Clinical and radiographic outcomes of posterolateral lumbar spine fusion in humans using recombinant human bone morphogenetic protein-2: an average five-year follow-up study

Authors: Yoshito Katayama, Yukihiro Matsuyama, Hisatake Yoshihara, Yoshihito Sakai, Hiroshi Nakamura, Shiro Imagama, Zenya Ito, Norimitsu Wakao, Mitsuhiro Kamiya, Yasutsugu Yukawa, Tokumi Kanemura, Koji Sato, Hisashi Iwata, Naoki Ishiguro

Published in: International Orthopaedics | Issue 4/2009

Abstract

The objectives of this study were to determine whether recombinant human bone morphogenetic protein-2 (rhBMP-2) can be used as the sole stimulator of osteogenesis with success equal to an autologous graft in posterolateral lumbar fusion (PLF) at the same level and to describe the progress until bone union. This study included 11 patients who underwent PLF of L4-5. On the right side, only rhBMP-2, for which polylactic/glycolic acid (PLGA) was used as a carrier, was used, whereas, on the left side, autogenous bone was used. The bone union rate was 73 and 82% at 12 and 24 months after surgery, respectively, on the right BMP side, while the rate on the autogenous bone side was 91%. There was no statistically significant difference in the bone union rate. rhBMP-2 can be used as the sole source of osteogenesis with success equivalent to an autologous graft of the PLF.

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Title: Clinical and radiographic outcomes of posterolateral lumbar spine fusion in humans using recombinant human bone morphogenetic protein-2: an average five-year follow-up study
Authors: Yoshito Katayama
Yukihiro Matsuyama
Hisatake Yoshihara
Yoshihito Sakai
Hiroshi Nakamura
Shiro Imagama
Zenya Ito
Norimitsu Wakao
Mitsuhiro Kamiya
Yasutsugu Yukawa
Tokumi Kanemura
Koji Sato
Hisashi Iwata
Naoki Ishiguro
Publication date: 01-08-2009
Publisher: Springer-Verlag
Published in: International Orthopaedics / Issue 4/2009
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-008-0600-5

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Clinical and radiographic outcomes of posterolateral lumbar spine fusion in humans using recombinant human bone morphogenetic protein-2: an average five-year follow-up study

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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