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Published in: Pediatric Nephrology 3/2020

01-03-2020 | Urolithiasis | Educational Review

Educational review: role of the pediatric nephrologists in the work-up and management of kidney stones

Authors: Carmen Inés Rodriguez Cuellar, Peter Zhan Tao Wang, Michael Freundlich, Guido Filler

Published in: Pediatric Nephrology | Issue 3/2020

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Abstract

Background

The incidence of nephrolithiasis in children and adolescents is increasing and appears to double every 10 years. The most important role of the pediatric nephrologist is to diagnose and modify various metabolic and non-metabolic risk factors, as well as prevent long-term complications especially in the case of recurrent nephrolithiasis.

Objective

The purpose of this review is to summarize the existing literature on the etiology and management of pediatric nephrolithiasis.

Results

The incidence of kidney stones is increasing; dietary and environmental factors are probably the main causes for this increased incidence. In most pediatric patients, the etiology for the kidney stones can be identified. Metabolic factors, such as hypercalciuria and hypocitraturia, urinary tract infection, and urinary stasis, constitute leading causes. Herein, we review the etiologies, diagnostic work-up, and treatment options for the most prevalent causes of kidney stones. The detrimental effects of excessive dietary sodium, reduced fluid intake, and the benefits of plant-based over animal-based protein consumption on urinary crystal formation are discussed. We also review the long-term complications.

Conclusions

Pediatric nephrologists have an important role in the diagnostic work-up and prevention of recurring nephrolithiasis.
Literature
1.
2.
go back to reference Scales CD Jr, Smith AC, Hanley JM, Saigal CS, Urologic Diseases in America P (2012) Prevalence of kidney stones in the United States. Eur Urol 62:160–165PubMedPubMedCentralCrossRef Scales CD Jr, Smith AC, Hanley JM, Saigal CS, Urologic Diseases in America P (2012) Prevalence of kidney stones in the United States. Eur Urol 62:160–165PubMedPubMedCentralCrossRef
4.
go back to reference Kusumi K, Becknell B, Schwaderer A (2015) Trends in pediatric urolithiasis: patient characteristics, associated diagnoses, and financial burden. Pediatr Nephrol 30:805–810PubMedCrossRef Kusumi K, Becknell B, Schwaderer A (2015) Trends in pediatric urolithiasis: patient characteristics, associated diagnoses, and financial burden. Pediatr Nephrol 30:805–810PubMedCrossRef
6.
go back to reference Sas DJ, Hulsey TC, Shatat IF, Orak JK (2010) Increasing incidence of kidney stones in children evaluated in the emergency department. J Pediatr 157:132–137PubMedCrossRef Sas DJ, Hulsey TC, Shatat IF, Orak JK (2010) Increasing incidence of kidney stones in children evaluated in the emergency department. J Pediatr 157:132–137PubMedCrossRef
7.
go back to reference Fakheri RJ, Goldfarb DS (2011) Ambient temperature as a contributor to kidney stone formation: implications of global warming. Kidney Int 79:1178–1185PubMedCrossRef Fakheri RJ, Goldfarb DS (2011) Ambient temperature as a contributor to kidney stone formation: implications of global warming. Kidney Int 79:1178–1185PubMedCrossRef
8.
go back to reference Brikowski TH, Lotan Y, Pearle MS (2008) Climate-related increase in the prevalence of urolithiasis in the United States. Proc Natl Acad Sci U S A 105:9841–9846PubMedPubMedCentralCrossRef Brikowski TH, Lotan Y, Pearle MS (2008) Climate-related increase in the prevalence of urolithiasis in the United States. Proc Natl Acad Sci U S A 105:9841–9846PubMedPubMedCentralCrossRef
9.
go back to reference Safarinejad MR (2007) Adult urolithiasis in a population-based study in Iran: prevalence, incidence, and associated risk factors. Urol Res 35:73–82PubMedCrossRef Safarinejad MR (2007) Adult urolithiasis in a population-based study in Iran: prevalence, incidence, and associated risk factors. Urol Res 35:73–82PubMedCrossRef
10.
go back to reference Jazayeri SM, Mamaghani ME, Pourmoghaddam A, Azarfar A, Beni MH, Emam SJ (2011) Need for emergent studies on dietary factors among infancy nephrolithiasis. Arch Ital Urol Androl 83:133–135PubMed Jazayeri SM, Mamaghani ME, Pourmoghaddam A, Azarfar A, Beni MH, Emam SJ (2011) Need for emergent studies on dietary factors among infancy nephrolithiasis. Arch Ital Urol Androl 83:133–135PubMed
11.
go back to reference Issler N, Dufek S, Kleta R, Bockenhauer D, Smeulders N, Van’t Hoff W (2017) Epidemiology of paediatric renal stone disease: a 22-year single centre experience in the UK. BMC Nephrol 18:136PubMedPubMedCentralCrossRef Issler N, Dufek S, Kleta R, Bockenhauer D, Smeulders N, Van’t Hoff W (2017) Epidemiology of paediatric renal stone disease: a 22-year single centre experience in the UK. BMC Nephrol 18:136PubMedPubMedCentralCrossRef
12.
go back to reference Cochat P, Pichault V, Bacchetta J, Dubourg L, Sabot JF, Saban C, Daudon M, Liutkus A (2010) Nephrolithiasis related to inborn metabolic diseases. Pediatr Nephrol 25:415–424PubMedCrossRef Cochat P, Pichault V, Bacchetta J, Dubourg L, Sabot JF, Saban C, Daudon M, Liutkus A (2010) Nephrolithiasis related to inborn metabolic diseases. Pediatr Nephrol 25:415–424PubMedCrossRef
13.
go back to reference Halbritter J, Baum M, Hynes AM, Rice SJ, Thwaites DT, Gucev ZS, Fisher B, Spaneas L, Porath JD, Braun DA, Wassner AJ, Nelson CP, Tasic V, Sayer JA, Hildebrandt F (2015) Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis. J Am Soc Nephrol 26:543–551PubMedCrossRef Halbritter J, Baum M, Hynes AM, Rice SJ, Thwaites DT, Gucev ZS, Fisher B, Spaneas L, Porath JD, Braun DA, Wassner AJ, Nelson CP, Tasic V, Sayer JA, Hildebrandt F (2015) Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis. J Am Soc Nephrol 26:543–551PubMedCrossRef
14.
go back to reference Halbritter J, Seidel A, Muller L, Schonauer R, Hoppe B (2018) Update on hereditary kidney stone disease and introduction of a new clinical patient registry in Germany. Front Pediatr 6:47PubMedPubMedCentralCrossRef Halbritter J, Seidel A, Muller L, Schonauer R, Hoppe B (2018) Update on hereditary kidney stone disease and introduction of a new clinical patient registry in Germany. Front Pediatr 6:47PubMedPubMedCentralCrossRef
15.
go back to reference Tasian GE, Ross ME, Song L, Sas DJ, Keren R, Denburg MR, Chu DI, Copelovitch L, Saigal CS, Furth SL (2016) Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997 to 2012. Clin J Am Soc Nephrol 11:488–496PubMedPubMedCentralCrossRef Tasian GE, Ross ME, Song L, Sas DJ, Keren R, Denburg MR, Chu DI, Copelovitch L, Saigal CS, Furth SL (2016) Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997 to 2012. Clin J Am Soc Nephrol 11:488–496PubMedPubMedCentralCrossRef
16.
go back to reference Edvardsson VO, Ingvarsdottir SE, Palsson R, Indridason OS (2018) Incidence of kidney stone disease in Icelandic children and adolescents from 1985 to 2013: results of a nationwide study. Pediatr Nephrol 33:1375–1384PubMedCrossRef Edvardsson VO, Ingvarsdottir SE, Palsson R, Indridason OS (2018) Incidence of kidney stone disease in Icelandic children and adolescents from 1985 to 2013: results of a nationwide study. Pediatr Nephrol 33:1375–1384PubMedCrossRef
17.
go back to reference James WP, Ralph A, Sanchez-Castillo CP (1987) The dominance of salt in manufactured food in the sodium intake of affluent societies. Lancet 1:426–429PubMedCrossRef James WP, Ralph A, Sanchez-Castillo CP (1987) The dominance of salt in manufactured food in the sodium intake of affluent societies. Lancet 1:426–429PubMedCrossRef
18.
go back to reference (2010) In: Henney JE, Taylor CL, Boon CS (eds) Strategies to Reduce Sodium Intake in the United States, Washington (DC) (2010) In: Henney JE, Taylor CL, Boon CS (eds) Strategies to Reduce Sodium Intake in the United States, Washington (DC)
19.
go back to reference Centers for Disease C, Prevention (2011) Usual sodium intakes compared with current dietary guidelines—United States, 2005–2008. MMWR Morb Mortal Wkly Rep 60:1413–1417 Centers for Disease C, Prevention (2011) Usual sodium intakes compared with current dietary guidelines—United States, 2005–2008. MMWR Morb Mortal Wkly Rep 60:1413–1417
20.
go back to reference Centers for Disease C, Prevention (2012) Vital signs: food categories contributing the most to sodium consumption—United States, 2007–2008. MMWR Morb Mortal Wkly Rep 61:92–98 Centers for Disease C, Prevention (2012) Vital signs: food categories contributing the most to sodium consumption—United States, 2007–2008. MMWR Morb Mortal Wkly Rep 61:92–98
21.
go back to reference Picon RV, Fuchs FD, Moreira LB, Fuchs SC (2013) Prevalence of hypertension among elderly persons in urban Brazil: a systematic review with meta-analysis. Am J Hypertens 26:541–548PubMedCrossRef Picon RV, Fuchs FD, Moreira LB, Fuchs SC (2013) Prevalence of hypertension among elderly persons in urban Brazil: a systematic review with meta-analysis. Am J Hypertens 26:541–548PubMedCrossRef
22.
go back to reference Nordin BE, Need AG, Morris HA, Horowitz M (1993) The nature and significance of the relationship between urinary sodium and urinary calcium in women. J Nutr 123:1615–1622PubMedCrossRef Nordin BE, Need AG, Morris HA, Horowitz M (1993) The nature and significance of the relationship between urinary sodium and urinary calcium in women. J Nutr 123:1615–1622PubMedCrossRef
23.
go back to reference Matkovic V, Ilich JZ, Andon MB, Hsieh LC, Tzagournis MA, Lagger BJ, Goel PK (1995) Urinary calcium, sodium, and bone mass of young females. Am J Clin Nutr 62:417–425PubMedCrossRef Matkovic V, Ilich JZ, Andon MB, Hsieh LC, Tzagournis MA, Lagger BJ, Goel PK (1995) Urinary calcium, sodium, and bone mass of young females. Am J Clin Nutr 62:417–425PubMedCrossRef
24.
go back to reference Osorio AV, Alon US (1997) The relationship between urinary calcium, sodium, and potassium excretion and the role of potassium in treating idiopathic hypercalciuria. Pediatrics 100:675–681PubMedCrossRef Osorio AV, Alon US (1997) The relationship between urinary calcium, sodium, and potassium excretion and the role of potassium in treating idiopathic hypercalciuria. Pediatrics 100:675–681PubMedCrossRef
25.
go back to reference Kovacevic L, Wolfe-Christensen C, Edwards L, Sadaps M, Lakshmanan Y (2012) From hypercalciuria to hypocitraturia—a shifting trend in pediatric urolithiasis? J Urol 188:1623–1627PubMedCrossRef Kovacevic L, Wolfe-Christensen C, Edwards L, Sadaps M, Lakshmanan Y (2012) From hypercalciuria to hypocitraturia—a shifting trend in pediatric urolithiasis? J Urol 188:1623–1627PubMedCrossRef
26.
go back to reference Heilberg IP, Goldfarb DS (2013) Optimum nutrition for kidney stone disease. Adv Kidney Dis 20:165–174CrossRef Heilberg IP, Goldfarb DS (2013) Optimum nutrition for kidney stone disease. Adv Kidney Dis 20:165–174CrossRef
27.
go back to reference Sellmeyer DE, Schloetter M, Sebastian A (2002) Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab 87:2008–2012PubMedCrossRef Sellmeyer DE, Schloetter M, Sebastian A (2002) Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab 87:2008–2012PubMedCrossRef
29.
go back to reference Shavit L, Ferraro PM, Johri N, Robertson W, Walsh SB, Moochhala S, Unwin R (2015) Effect of being overweight on urinary metabolic risk factors for kidney stone formation. Nephrol Dial Transplant 30:607–613PubMedCrossRef Shavit L, Ferraro PM, Johri N, Robertson W, Walsh SB, Moochhala S, Unwin R (2015) Effect of being overweight on urinary metabolic risk factors for kidney stone formation. Nephrol Dial Transplant 30:607–613PubMedCrossRef
30.
go back to reference Caltik Yilmaz A, Buyukkaragoz B, Oguz U, Celik B (2015) Influence of body mass index on pediatric urolithiasis. J Pediatr Urol 11(350):e351–e356 Caltik Yilmaz A, Buyukkaragoz B, Oguz U, Celik B (2015) Influence of body mass index on pediatric urolithiasis. J Pediatr Urol 11(350):e351–e356
31.
go back to reference Kuroczycka-Saniutycz E, Porowski T, Protas PT, Pszczolkowska M, Porowska H, Kirejczyk JK, Wasilewska A (2015) Does obesity or hyperuricemia influence lithogenic risk profile in children with urolithiasis? Pediatr Nephrol 30:797–803PubMedCrossRef Kuroczycka-Saniutycz E, Porowski T, Protas PT, Pszczolkowska M, Porowska H, Kirejczyk JK, Wasilewska A (2015) Does obesity or hyperuricemia influence lithogenic risk profile in children with urolithiasis? Pediatr Nephrol 30:797–803PubMedCrossRef
32.
34.
go back to reference Copelovitch L (2012) Urolithiasis in children: medical approach. Pediatr Clin N Am 59:881–896CrossRef Copelovitch L (2012) Urolithiasis in children: medical approach. Pediatr Clin N Am 59:881–896CrossRef
36.
go back to reference Srivastava T, Schwaderer A (2009) Diagnosis and management of hypercalciuria in children. Curr Opin Pediatr 21:214–219PubMedCrossRef Srivastava T, Schwaderer A (2009) Diagnosis and management of hypercalciuria in children. Curr Opin Pediatr 21:214–219PubMedCrossRef
37.
38.
go back to reference Passerotti C, Chow JS, Silva A, Schoettler CL, Rosoklija I, Perez-Rossello J, Cendron M, Cilento BG, Lee RS, Nelson CP, Estrada CR, Bauer SB, Borer JG, Diamond DA, Retik AB, Nguyen HT (2009) Ultrasound versus computerized tomography for evaluating urolithiasis. J Urol 182:1829–1834PubMedCrossRef Passerotti C, Chow JS, Silva A, Schoettler CL, Rosoklija I, Perez-Rossello J, Cendron M, Cilento BG, Lee RS, Nelson CP, Estrada CR, Bauer SB, Borer JG, Diamond DA, Retik AB, Nguyen HT (2009) Ultrasound versus computerized tomography for evaluating urolithiasis. J Urol 182:1829–1834PubMedCrossRef
39.
go back to reference Tasian GE, Copelovitch L (2014) Evaluation and medical management of kidney stones in children. J Urol 192:1329–1336PubMedCrossRef Tasian GE, Copelovitch L (2014) Evaluation and medical management of kidney stones in children. J Urol 192:1329–1336PubMedCrossRef
40.
go back to reference Tefekli A, Esen T, Ziylan O, Erol B, Armagan A, Ander H, Akinci M (2003) Metabolic risk factors in pediatric and adult calcium oxalate urinary stone formers: is there any difference? Urol Int 70:273–277PubMedCrossRef Tefekli A, Esen T, Ziylan O, Erol B, Armagan A, Ander H, Akinci M (2003) Metabolic risk factors in pediatric and adult calcium oxalate urinary stone formers: is there any difference? Urol Int 70:273–277PubMedCrossRef
41.
go back to reference Edvardsson VO, Goldfarb DS, Lieske JC, Beara-Lasic L, Anglani F, Milliner DS, Palsson R (2013) Hereditary causes of kidney stones and chronic kidney disease. Pediatr Nephrol 28:1923–1942PubMedPubMedCentralCrossRef Edvardsson VO, Goldfarb DS, Lieske JC, Beara-Lasic L, Anglani F, Milliner DS, Palsson R (2013) Hereditary causes of kidney stones and chronic kidney disease. Pediatr Nephrol 28:1923–1942PubMedPubMedCentralCrossRef
43.
go back to reference Worcester EM, Coe FL, Evan AP, Bergsland KJ, Parks JH, Willis LR, Clark DL, Gillen DL (2008) Evidence for increased postprandial distal nephron calcium delivery in hypercalciuric stone-forming patients. Am J Physiol Renal Physiol 295:F1286–F1294PubMedPubMedCentralCrossRef Worcester EM, Coe FL, Evan AP, Bergsland KJ, Parks JH, Willis LR, Clark DL, Gillen DL (2008) Evidence for increased postprandial distal nephron calcium delivery in hypercalciuric stone-forming patients. Am J Physiol Renal Physiol 295:F1286–F1294PubMedPubMedCentralCrossRef
45.
go back to reference Arrabal-Polo MA, Arias-Santiago S, Giron-Prieto MS, Abad-Menor F, Lopez-Carmona Pintado F, Zuluaga-Gomez A, Arrabal-Martin M (2012) Hypercalciuria, hyperoxaluria, and hypocitraturia screening from random urine samples in patients with calcium lithiasis. Urol Res 40:511–515PubMedCrossRef Arrabal-Polo MA, Arias-Santiago S, Giron-Prieto MS, Abad-Menor F, Lopez-Carmona Pintado F, Zuluaga-Gomez A, Arrabal-Martin M (2012) Hypercalciuria, hyperoxaluria, and hypocitraturia screening from random urine samples in patients with calcium lithiasis. Urol Res 40:511–515PubMedCrossRef
46.
go back to reference Butani L, Kalia A (2004) Idiopathic hypercalciuria in children—how valid are the existing diagnostic criteria? Pediatr Nephrol 19:577–582PubMedCrossRef Butani L, Kalia A (2004) Idiopathic hypercalciuria in children—how valid are the existing diagnostic criteria? Pediatr Nephrol 19:577–582PubMedCrossRef
47.
go back to reference Penniston KL, Nakada SY (2018) Updates in the metabolic management of calcium stones. Curr Urol Rep 19:41PubMedCrossRef Penniston KL, Nakada SY (2018) Updates in the metabolic management of calcium stones. Curr Urol Rep 19:41PubMedCrossRef
48.
go back to reference Sakhaee K, Nicar M, Hill K, Pak CY (1983) Contrasting effects of potassium citrate and sodium citrate therapies on urinary chemistries and crystallization of stone-forming salts. Kidney Int 24:348–352PubMedCrossRef Sakhaee K, Nicar M, Hill K, Pak CY (1983) Contrasting effects of potassium citrate and sodium citrate therapies on urinary chemistries and crystallization of stone-forming salts. Kidney Int 24:348–352PubMedCrossRef
49.
51.
52.
go back to reference Domrongkitchaiporn S, Stitchantrakul W, Kochakarn W (2006) Causes of hypocitraturia in recurrent calcium stone formers: focusing on urinary potassium excretion. Am J Kidney Dis 48:546–554PubMedCrossRef Domrongkitchaiporn S, Stitchantrakul W, Kochakarn W (2006) Causes of hypocitraturia in recurrent calcium stone formers: focusing on urinary potassium excretion. Am J Kidney Dis 48:546–554PubMedCrossRef
53.
go back to reference Nishijima S, Sugaya K, Naito A, Morozumi M, Hatano T, Ogawa Y (2002) Association of vitamin D receptor gene polymorphism with urolithiasis. J Urol 167:2188–2191PubMedCrossRef Nishijima S, Sugaya K, Naito A, Morozumi M, Hatano T, Ogawa Y (2002) Association of vitamin D receptor gene polymorphism with urolithiasis. J Urol 167:2188–2191PubMedCrossRef
54.
go back to reference Mossetti G, Vuotto P, Rendina D, Numis FG, Viceconti R, Giordano F, Cioffi M, Scopacasa F, Nunziata V (2003) Association between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis. J Intern Med 253:194–200PubMedCrossRef Mossetti G, Vuotto P, Rendina D, Numis FG, Viceconti R, Giordano F, Cioffi M, Scopacasa F, Nunziata V (2003) Association between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis. J Intern Med 253:194–200PubMedCrossRef
55.
go back to reference Corbin Bush N, Twombley K, Ahn J, Oliveira C, Arnold S, Maalouf NM, Sakhaee K (2013) Prevalence and spot urine risk factors for renal stones in children taking topiramate. J Pediatr Urol 9:884–889PubMedCrossRef Corbin Bush N, Twombley K, Ahn J, Oliveira C, Arnold S, Maalouf NM, Sakhaee K (2013) Prevalence and spot urine risk factors for renal stones in children taking topiramate. J Pediatr Urol 9:884–889PubMedCrossRef
56.
go back to reference Srivastava T, Winston MJ, Auron A, Alon US (2009) Urine calcium/citrate ratio in children with hypercalciuric stones. Pediatr Res 66:85–90PubMedCrossRef Srivastava T, Winston MJ, Auron A, Alon US (2009) Urine calcium/citrate ratio in children with hypercalciuric stones. Pediatr Res 66:85–90PubMedCrossRef
57.
go back to reference DeFoor W, Jackson E, Schulte M, Alam Z, Asplin J (2017) Calcium-to-citrate ratio distinguishes solitary and recurrent urinary stone forming children. J Urol 198:416–421PubMedCrossRef DeFoor W, Jackson E, Schulte M, Alam Z, Asplin J (2017) Calcium-to-citrate ratio distinguishes solitary and recurrent urinary stone forming children. J Urol 198:416–421PubMedCrossRef
58.
go back to reference Bastug F, Dusunsel R (2012) Pediatric urolithiasis: causative factors, diagnosis and medical management. Nat Rev Urol 9:138–146PubMedCrossRef Bastug F, Dusunsel R (2012) Pediatric urolithiasis: causative factors, diagnosis and medical management. Nat Rev Urol 9:138–146PubMedCrossRef
59.
go back to reference Kang DE, Sur RL, Haleblian GE, Fitzsimons NJ, Borawski KM, Preminger GM (2007) Long-term lemonade based dietary manipulation in patients with hypocitraturic nephrolithiasis. J Urol 177:1358–1362 discussion 1362; quiz 1591PubMedCrossRef Kang DE, Sur RL, Haleblian GE, Fitzsimons NJ, Borawski KM, Preminger GM (2007) Long-term lemonade based dietary manipulation in patients with hypocitraturic nephrolithiasis. J Urol 177:1358–1362 discussion 1362; quiz 1591PubMedCrossRef
60.
go back to reference Penniston KL, Nakada SY, Holmes RP, Assimos DG (2008) Quantitative assessment of citric acid in lemon juice, lime juice, and commercially-available fruit juice products. J Endourol 22:567–570PubMedCrossRef Penniston KL, Nakada SY, Holmes RP, Assimos DG (2008) Quantitative assessment of citric acid in lemon juice, lime juice, and commercially-available fruit juice products. J Endourol 22:567–570PubMedCrossRef
61.
go back to reference Rahman MM, Abdullah RB, Wan Khadijah WE (2013) A review of oxalate poisoning in domestic animals: tolerance and performance aspects. J Anim Physiol Anim Nutr (Berl) 97:605–614CrossRef Rahman MM, Abdullah RB, Wan Khadijah WE (2013) A review of oxalate poisoning in domestic animals: tolerance and performance aspects. J Anim Physiol Anim Nutr (Berl) 97:605–614CrossRef
62.
64.
go back to reference Danpure CJ, Rumsby G (2004) Molecular aetiology of primary hyperoxaluria and its implications for clinical management. Expert Rev Mol Med 6:1–16PubMedCrossRef Danpure CJ, Rumsby G (2004) Molecular aetiology of primary hyperoxaluria and its implications for clinical management. Expert Rev Mol Med 6:1–16PubMedCrossRef
65.
go back to reference Lorenzo V, Torres A, Salido E (2014) Primary hyperoxaluria. Nefrologia 34:398–412PubMed Lorenzo V, Torres A, Salido E (2014) Primary hyperoxaluria. Nefrologia 34:398–412PubMed
66.
go back to reference Monico CG, Rossetti S, Belostotsky R, Cogal AG, Herges RM, Seide BM, Olson JB, Bergstrahl EJ, Williams HJ, Haley WE, Frishberg Y, Milliner DS (2011) Primary hyperoxaluria type III gene HOGA1 (formerly DHDPSL) as a possible risk factor for idiopathic calcium oxalate urolithiasis. Clin J Am Soc Nephrol 6:2289–2295PubMedPubMedCentralCrossRef Monico CG, Rossetti S, Belostotsky R, Cogal AG, Herges RM, Seide BM, Olson JB, Bergstrahl EJ, Williams HJ, Haley WE, Frishberg Y, Milliner DS (2011) Primary hyperoxaluria type III gene HOGA1 (formerly DHDPSL) as a possible risk factor for idiopathic calcium oxalate urolithiasis. Clin J Am Soc Nephrol 6:2289–2295PubMedPubMedCentralCrossRef
68.
go back to reference Milliner DS, Eickholt JT, Bergstralh EJ, Wilson DM, Smith LH (1994) Results of long-term treatment with orthophosphate and pyridoxine in patients with primary hyperoxaluria. N Engl J Med 331:1553–1558PubMedCrossRef Milliner DS, Eickholt JT, Bergstralh EJ, Wilson DM, Smith LH (1994) Results of long-term treatment with orthophosphate and pyridoxine in patients with primary hyperoxaluria. N Engl J Med 331:1553–1558PubMedCrossRef
69.
go back to reference Zimmermann DJ, Voss S, von Unruh GE, Hesse A (2005) Importance of magnesium in absorption and excretion of oxalate. Urol Int 74:262–267PubMedCrossRef Zimmermann DJ, Voss S, von Unruh GE, Hesse A (2005) Importance of magnesium in absorption and excretion of oxalate. Urol Int 74:262–267PubMedCrossRef
70.
go back to reference Milliner D (2006) Treatment of the primary hyperoxalurias: a new chapter. Kidney Int 70:1198–1200PubMedCrossRef Milliner D (2006) Treatment of the primary hyperoxalurias: a new chapter. Kidney Int 70:1198–1200PubMedCrossRef
71.
go back to reference Hoppe B, Kemper MJ, Bokenkamp A, Portale AA, Cohn RA, Langman CB (1999) Plasma calcium oxalate supersaturation in children with primary hyperoxaluria and end-stage renal failure. Kidney Int 56:268–274PubMedCrossRef Hoppe B, Kemper MJ, Bokenkamp A, Portale AA, Cohn RA, Langman CB (1999) Plasma calcium oxalate supersaturation in children with primary hyperoxaluria and end-stage renal failure. Kidney Int 56:268–274PubMedCrossRef
72.
go back to reference Compagnon P, Metzler P, Samuel D, Camus C, Niaudet P, Durrbach A, Lang P, Azoulay D, Duvoux C, Bayle F, Rivalan J, Merville P, Pascal G, Thervet E, Bensman A, Rostaing L, Deschenes G, Morcet J, Feray C, Boudjema K (2014) Long-term results of combined liver-kidney transplantation for primary hyperoxaluria type 1: the French experience. Liver Transpl 20:1475–1485PubMed Compagnon P, Metzler P, Samuel D, Camus C, Niaudet P, Durrbach A, Lang P, Azoulay D, Duvoux C, Bayle F, Rivalan J, Merville P, Pascal G, Thervet E, Bensman A, Rostaing L, Deschenes G, Morcet J, Feray C, Boudjema K (2014) Long-term results of combined liver-kidney transplantation for primary hyperoxaluria type 1: the French experience. Liver Transpl 20:1475–1485PubMed
73.
go back to reference Millan MT, Berquist WE, So SK, Sarwal MM, Wayman KI, Cox KL, Filler G, Salvatierra O Jr, Esquivel CO (2003) One hundred percent patient and kidney allograft survival with simultaneous liver and kidney transplantation in infants with primary hyperoxaluria: a single-center experience. Transplantation 76:1458–1463PubMedCrossRef Millan MT, Berquist WE, So SK, Sarwal MM, Wayman KI, Cox KL, Filler G, Salvatierra O Jr, Esquivel CO (2003) One hundred percent patient and kidney allograft survival with simultaneous liver and kidney transplantation in infants with primary hyperoxaluria: a single-center experience. Transplantation 76:1458–1463PubMedCrossRef
74.
go back to reference Mehta TH, Goldfarb DS (2012) Uric acid stones and hyperuricosuria. Adv Chronic Kidney Dis 19:413–418PubMedCrossRef Mehta TH, Goldfarb DS (2012) Uric acid stones and hyperuricosuria. Adv Chronic Kidney Dis 19:413–418PubMedCrossRef
75.
go back to reference Vasudevan V, Samson P, Smith AD, Okeke Z (2017) The genetic framework for development of nephrolithiasis. Asian J Urol 4:18–26PubMedCrossRef Vasudevan V, Samson P, Smith AD, Okeke Z (2017) The genetic framework for development of nephrolithiasis. Asian J Urol 4:18–26PubMedCrossRef
77.
go back to reference Chillaron J, Font-Llitjos M, Fort J, Zorzano A, Goldfarb DS, Nunes V, Palacin M (2010) Pathophysiology and treatment of cystinuria. Nat Rev Pediatr Nephrol 6:424–434CrossRef Chillaron J, Font-Llitjos M, Fort J, Zorzano A, Goldfarb DS, Nunes V, Palacin M (2010) Pathophysiology and treatment of cystinuria. Nat Rev Pediatr Nephrol 6:424–434CrossRef
78.
go back to reference Wong KA, Mein R, Wass M, Flinter F, Pardy C, Bultitude M, Thomas K (2015) The genetic diversity of cystinuria in a UK population of patients. BJU Int 116:109–116PubMedCrossRef Wong KA, Mein R, Wass M, Flinter F, Pardy C, Bultitude M, Thomas K (2015) The genetic diversity of cystinuria in a UK population of patients. BJU Int 116:109–116PubMedCrossRef
79.
go back to reference Afsar B, Kiremit MC, Sag AA, Tarim K, Acar O, Esen T, Solak Y, Covic A, Kanbay M (2016) The role of sodium intake in nephrolithiasis: epidemiology, pathogenesis, and future directions. Eur J Intern Med 35:16–19PubMedCrossRef Afsar B, Kiremit MC, Sag AA, Tarim K, Acar O, Esen T, Solak Y, Covic A, Kanbay M (2016) The role of sodium intake in nephrolithiasis: epidemiology, pathogenesis, and future directions. Eur J Intern Med 35:16–19PubMedCrossRef
80.
go back to reference Printza N, Koukourgianni F, Papathanasiou A, Augoustides-Savvopoulou P, Papachristou F (2007) Efficacy of captopril therapy in cystinuria lithiasis. A case report. Hippokratia 11:83–85PubMedPubMedCentral Printza N, Koukourgianni F, Papathanasiou A, Augoustides-Savvopoulou P, Papachristou F (2007) Efficacy of captopril therapy in cystinuria lithiasis. A case report. Hippokratia 11:83–85PubMedPubMedCentral
81.
go back to reference Alonso-Varela M, Gil-Pena H, Coto E, Gomez J, Rodriguez J, Rodriguez-Rubio E, Santos F, RenalTube G (2018) Distal renal tubular acidosis. Clinical manifestations in patients with different underlying gene mutations. Pediatr Nephrol 33:1523–1529PubMedCrossRef Alonso-Varela M, Gil-Pena H, Coto E, Gomez J, Rodriguez J, Rodriguez-Rubio E, Santos F, RenalTube G (2018) Distal renal tubular acidosis. Clinical manifestations in patients with different underlying gene mutations. Pediatr Nephrol 33:1523–1529PubMedCrossRef
82.
go back to reference Grases F, Costa-Bauza A, Gomila I, Ramis M, Garcia-Raja A, Prieto RM (2012) Urinary pH and renal lithiasis. Urol Res 40:41–46PubMedCrossRef Grases F, Costa-Bauza A, Gomila I, Ramis M, Garcia-Raja A, Prieto RM (2012) Urinary pH and renal lithiasis. Urol Res 40:41–46PubMedCrossRef
83.
go back to reference Lindberg J, Harvey J, Pak CY (1990) Effect of magnesium citrate and magnesium oxide on the crystallization of calcium salts in urine: changes produced by food-magnesium interaction. J Urol 143:248–251PubMedCrossRef Lindberg J, Harvey J, Pak CY (1990) Effect of magnesium citrate and magnesium oxide on the crystallization of calcium salts in urine: changes produced by food-magnesium interaction. J Urol 143:248–251PubMedCrossRef
84.
go back to reference Robertson WG (2017) Do “inhibitors of crystallisation” play any role in the prevention of kidney stones? A critique. Urolithiasis 45:43–56PubMedCrossRef Robertson WG (2017) Do “inhibitors of crystallisation” play any role in the prevention of kidney stones? A critique. Urolithiasis 45:43–56PubMedCrossRef
85.
go back to reference Vaidyanathan S, von Unruh GE, Watson ID, Laube N, Willets S, Soni BL (2006) Hyperoxaluria, hypocitraturia, hypomagnesiuria, and lack of intestinal colonization by Oxalobacter formigenes in a cervical spinal cord injury patient with suprapubic cystostomy, short bowel, and nephrolithiasis. ScientificWorldJournal 6:2403–2410PubMedPubMedCentralCrossRef Vaidyanathan S, von Unruh GE, Watson ID, Laube N, Willets S, Soni BL (2006) Hyperoxaluria, hypocitraturia, hypomagnesiuria, and lack of intestinal colonization by Oxalobacter formigenes in a cervical spinal cord injury patient with suprapubic cystostomy, short bowel, and nephrolithiasis. ScientificWorldJournal 6:2403–2410PubMedPubMedCentralCrossRef
86.
go back to reference Hedelin H (2002) Uropathogens and urinary tract concretion formation and catheter encrustations. Int J Antimicrob Agents 19:484–487PubMedCrossRef Hedelin H (2002) Uropathogens and urinary tract concretion formation and catheter encrustations. Int J Antimicrob Agents 19:484–487PubMedCrossRef
87.
go back to reference Borghi L, Nouvenne A, Meschi T (2012) Nephrolithiasis and urinary tract infections: ‘the chicken or the egg’ dilemma? Nephrol Dial Transplant 27:3982–3984PubMedCrossRef Borghi L, Nouvenne A, Meschi T (2012) Nephrolithiasis and urinary tract infections: ‘the chicken or the egg’ dilemma? Nephrol Dial Transplant 27:3982–3984PubMedCrossRef
90.
go back to reference Siener R, Ebert D, Hesse A (2001) Urinary oxalate excretion in female calcium oxalate stone formers with and without a history of recurrent urinary tract infections. Urol Res 29:245–248PubMedCrossRef Siener R, Ebert D, Hesse A (2001) Urinary oxalate excretion in female calcium oxalate stone formers with and without a history of recurrent urinary tract infections. Urol Res 29:245–248PubMedCrossRef
91.
go back to reference Sas DJ (2011) An update on the changing epidemiology and metabolic risk factors in pediatric kidney stone disease. Clin J Am Soc Nephrol 6:2062–2068PubMedCrossRef Sas DJ (2011) An update on the changing epidemiology and metabolic risk factors in pediatric kidney stone disease. Clin J Am Soc Nephrol 6:2062–2068PubMedCrossRef
92.
go back to reference Siroky MB (2002) Pathogenesis of bacteriuria and infection in the spinal cord injured patient. Am J Med 113(Suppl 1A):67S–79SPubMedCrossRef Siroky MB (2002) Pathogenesis of bacteriuria and infection in the spinal cord injured patient. Am J Med 113(Suppl 1A):67S–79SPubMedCrossRef
93.
go back to reference Gambaro G, Fabris A, Puliatta D, Lupo A (2006) Lithiasis in cystic kidney disease and malformations of the urinary tract. Urol Res 34:102–107PubMedCrossRef Gambaro G, Fabris A, Puliatta D, Lupo A (2006) Lithiasis in cystic kidney disease and malformations of the urinary tract. Urol Res 34:102–107PubMedCrossRef
94.
go back to reference Yang EM, Yoon BA, Kim SW, Kim CJ (2017) Clinical utility of spot urine protein-to-creatinine ratio modified by estimated daily creatinine excretion in children. Pediatr Nephrol 32:1045–1051PubMedCrossRef Yang EM, Yoon BA, Kim SW, Kim CJ (2017) Clinical utility of spot urine protein-to-creatinine ratio modified by estimated daily creatinine excretion in children. Pediatr Nephrol 32:1045–1051PubMedCrossRef
95.
go back to reference Goldfarb DS, Arowojolu O (2013) Metabolic evaluation of first-time and recurrent stone formers. Urol Clin North Am 40:13–20PubMedCrossRef Goldfarb DS, Arowojolu O (2013) Metabolic evaluation of first-time and recurrent stone formers. Urol Clin North Am 40:13–20PubMedCrossRef
96.
go back to reference Ben-Shalom E, Frishberg Y (2015) Primary hyperoxalurias: diagnosis and treatment. Pediatr Nephrol 30:1781–1791PubMedCrossRef Ben-Shalom E, Frishberg Y (2015) Primary hyperoxalurias: diagnosis and treatment. Pediatr Nephrol 30:1781–1791PubMedCrossRef
97.
go back to reference Belostotsky R, Pitt JJ, Frishberg Y (2012) Primary hyperoxaluria type III—a model for studying perturbations in glyoxylate metabolism. J Mol Med (Berl) 90:1497–1504CrossRef Belostotsky R, Pitt JJ, Frishberg Y (2012) Primary hyperoxaluria type III—a model for studying perturbations in glyoxylate metabolism. J Mol Med (Berl) 90:1497–1504CrossRef
98.
99.
go back to reference Borghi L, Meschi T, Amato F, Briganti A, Novarini A, Giannini A (1996) Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study. J Urol 155:839–843PubMedCrossRef Borghi L, Meschi T, Amato F, Briganti A, Novarini A, Giannini A (1996) Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study. J Urol 155:839–843PubMedCrossRef
100.
101.
go back to reference Lande MB, Varade W, Erkan E, Niederbracht Y, Schwartz GJ (2005) Role of urinary supersaturation in the evaluation of children with urolithiasis. Pediatr Nephrol 20:491–494PubMedCrossRef Lande MB, Varade W, Erkan E, Niederbracht Y, Schwartz GJ (2005) Role of urinary supersaturation in the evaluation of children with urolithiasis. Pediatr Nephrol 20:491–494PubMedCrossRef
102.
go back to reference DeFoor W, Asplin J, Jackson E, Jackson C, Reddy P, Sheldon C, Erhard M, Minevich E (2006) Urinary metabolic evaluations in normal and stone forming children. J Urol 176:1793–1796PubMedCrossRef DeFoor W, Asplin J, Jackson E, Jackson C, Reddy P, Sheldon C, Erhard M, Minevich E (2006) Urinary metabolic evaluations in normal and stone forming children. J Urol 176:1793–1796PubMedCrossRef
103.
go back to reference McGuire S (2011) US Department of Agriculture and US Department of Health and Human Services, Dietary Guidelines for Americans, 2010. Washington, DC: US Government Printing Office, January 2011. Oxford University Press McGuire S (2011) US Department of Agriculture and US Department of Health and Human Services, Dietary Guidelines for Americans, 2010. Washington, DC: US Government Printing Office, January 2011. Oxford University Press
104.
go back to reference Heilberg IP, Weisinger JR (2006) Bone disease in idiopathic hypercalciuria. Curr Opin Nephrol Hypertens 15:394–402PubMedCrossRef Heilberg IP, Weisinger JR (2006) Bone disease in idiopathic hypercalciuria. Curr Opin Nephrol Hypertens 15:394–402PubMedCrossRef
105.
go back to reference Ross A, Taylor C, Yaktine A, Del Valle H (2011) Committee to review dietary reference intakes for vitamin D and calcium, food and nutrition board, Institute of Medicine. DRI dietary reference intakes for calcium and vitamin D. National Academies Press, Washington, DC http://www.nap.edu/catalog.php. Accessed 15 Aug 2018 Ross A, Taylor C, Yaktine A, Del Valle H (2011) Committee to review dietary reference intakes for vitamin D and calcium, food and nutrition board, Institute of Medicine. DRI dietary reference intakes for calcium and vitamin D. National Academies Press, Washington, DC http://​www.​nap.​edu/​catalog.​php. Accessed 15 Aug 2018
106.
go back to reference Hesse A, Schneeberger W, Engfeld S, Von Unruh GE, Sauerbruch T (1999) Intestinal hyperabsorption of oxalate in calcium oxalate stone formers: application of a new test with [13C2]oxalate. J Am Soc Nephrol 10(Suppl 14):S329–S333PubMed Hesse A, Schneeberger W, Engfeld S, Von Unruh GE, Sauerbruch T (1999) Intestinal hyperabsorption of oxalate in calcium oxalate stone formers: application of a new test with [13C2]oxalate. J Am Soc Nephrol 10(Suppl 14):S329–S333PubMed
107.
108.
go back to reference Freundlich M, Alonzo E, Bellorin-Font E, Weisinger JR (2002) Reduced bone mass in children with idiopathic hypercalciuria and in their asymptomatic mothers. Nephrol Dial Transplant 17:1396–1401PubMedCrossRef Freundlich M, Alonzo E, Bellorin-Font E, Weisinger JR (2002) Reduced bone mass in children with idiopathic hypercalciuria and in their asymptomatic mothers. Nephrol Dial Transplant 17:1396–1401PubMedCrossRef
109.
go back to reference Sakhaee K, Maalouf NM, Kumar R, Pasch A, Moe OW (2011) Nephrolithiasis-associated bone disease: pathogenesis and treatment options. Kidney Int 79:393–403PubMedCrossRef Sakhaee K, Maalouf NM, Kumar R, Pasch A, Moe OW (2011) Nephrolithiasis-associated bone disease: pathogenesis and treatment options. Kidney Int 79:393–403PubMedCrossRef
110.
go back to reference Denburg MR, Leonard MB, Haynes K, Tuchman S, Tasian G, Shults J, Copelovitch L (2014) Risk of fracture in urolithiasis: a population-based cohort study using the health improvement network. Clin J Am Soc Nephrol 9:2133–2140PubMedPubMedCentralCrossRef Denburg MR, Leonard MB, Haynes K, Tuchman S, Tasian G, Shults J, Copelovitch L (2014) Risk of fracture in urolithiasis: a population-based cohort study using the health improvement network. Clin J Am Soc Nephrol 9:2133–2140PubMedPubMedCentralCrossRef
111.
go back to reference Ferraro PM, Taylor EN, Eisner BH, Gambaro G, Rimm EB, Mukamal KJ, Curhan GC (2013) History of kidney stones and the risk of coronary heart disease. JAMA 310:408–415PubMedPubMedCentralCrossRef Ferraro PM, Taylor EN, Eisner BH, Gambaro G, Rimm EB, Mukamal KJ, Curhan GC (2013) History of kidney stones and the risk of coronary heart disease. JAMA 310:408–415PubMedPubMedCentralCrossRef
112.
go back to reference Rule AD, Roger VL, Melton LJ 3rd, Bergstralh EJ, Li X, Peyser PA, Krambeck AE, Lieske JC (2010) Kidney stones associate with increased risk for myocardial infarction. J Am Soc Nephrol 21:1641–1644PubMedPubMedCentralCrossRef Rule AD, Roger VL, Melton LJ 3rd, Bergstralh EJ, Li X, Peyser PA, Krambeck AE, Lieske JC (2010) Kidney stones associate with increased risk for myocardial infarction. J Am Soc Nephrol 21:1641–1644PubMedPubMedCentralCrossRef
113.
go back to reference Alexander RT, Hemmelgarn BR, Wiebe N, Bello A, Samuel S, Klarenbach SW, Curhan GC, Tonelli M, Alberta Kidney Disease N (2014) Kidney stones and cardiovascular events: a cohort study. Clin J Am Soc Nephrol 9:506–512PubMedCrossRef Alexander RT, Hemmelgarn BR, Wiebe N, Bello A, Samuel S, Klarenbach SW, Curhan GC, Tonelli M, Alberta Kidney Disease N (2014) Kidney stones and cardiovascular events: a cohort study. Clin J Am Soc Nephrol 9:506–512PubMedCrossRef
114.
go back to reference Liu Y, Li S, Zeng Z, Wang J, Xie L, Li T, He Y, Qin X, Zhao J (2014) Kidney stones and cardiovascular risk: a meta-analysis of cohort studies. Am J Kidney Dis 64:402–410PubMedCrossRef Liu Y, Li S, Zeng Z, Wang J, Xie L, Li T, He Y, Qin X, Zhao J (2014) Kidney stones and cardiovascular risk: a meta-analysis of cohort studies. Am J Kidney Dis 64:402–410PubMedCrossRef
115.
go back to reference Peng JP, Zheng H (2017) Kidney stones may increase the risk of coronary heart disease and stroke: a PRISMA-compliant meta-analysis. Medicine (Baltimore) 96:e7898CrossRef Peng JP, Zheng H (2017) Kidney stones may increase the risk of coronary heart disease and stroke: a PRISMA-compliant meta-analysis. Medicine (Baltimore) 96:e7898CrossRef
116.
go back to reference Fabris A, Ferraro PM, Comellato G, Caletti C, Fantin F, Zaza G, Zamboni M, Lupo A, Gambaro G (2015) The relationship between calcium kidney stones, arterial stiffness and bone density: unraveling the stone-bone-vessel liaison. J Nephrol 28:549–555PubMedCrossRef Fabris A, Ferraro PM, Comellato G, Caletti C, Fantin F, Zaza G, Zamboni M, Lupo A, Gambaro G (2015) The relationship between calcium kidney stones, arterial stiffness and bone density: unraveling the stone-bone-vessel liaison. J Nephrol 28:549–555PubMedCrossRef
117.
go back to reference Reiner AP, Kahn A, Eisner BH, Pletcher MJ, Sadetsky N, Williams OD, Polak JF, Jacobs DR Jr, Stoller ML (2011) Kidney stones and subclinical atherosclerosis in young adults: the CARDIA study. J Urol 185:920–925PubMedCrossRef Reiner AP, Kahn A, Eisner BH, Pletcher MJ, Sadetsky N, Williams OD, Polak JF, Jacobs DR Jr, Stoller ML (2011) Kidney stones and subclinical atherosclerosis in young adults: the CARDIA study. J Urol 185:920–925PubMedCrossRef
118.
go back to reference Kusumi K, Smith S, Barr-Beare E, Saxena V, Schober MS, Moore-Clingenpeel M, Schwaderer AL (2015) Pediatric origins of nephrolithiasis-associated atherosclerosis. J Pediatr 167:1074–1080 e1072PubMedCrossRef Kusumi K, Smith S, Barr-Beare E, Saxena V, Schober MS, Moore-Clingenpeel M, Schwaderer AL (2015) Pediatric origins of nephrolithiasis-associated atherosclerosis. J Pediatr 167:1074–1080 e1072PubMedCrossRef
119.
go back to reference Rule AD, Bergstralh EJ, Melton LJ 3rd, Li X, Weaver AL, Lieske JC (2009) Kidney stones and the risk for chronic kidney disease. Clin J Am Soc Nephrol 4:804–811PubMedPubMedCentralCrossRef Rule AD, Bergstralh EJ, Melton LJ 3rd, Li X, Weaver AL, Lieske JC (2009) Kidney stones and the risk for chronic kidney disease. Clin J Am Soc Nephrol 4:804–811PubMedPubMedCentralCrossRef
120.
go back to reference Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de Gonzalez A (2012) Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 380:499–505PubMedPubMedCentralCrossRef Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de Gonzalez A (2012) Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 380:499–505PubMedPubMedCentralCrossRef
Metadata
Title
Educational review: role of the pediatric nephrologists in the work-up and management of kidney stones
Authors
Carmen Inés Rodriguez Cuellar
Peter Zhan Tao Wang
Michael Freundlich
Guido Filler
Publication date
01-03-2020
Publisher
Springer Berlin Heidelberg
Keyword
Urolithiasis
Published in
Pediatric Nephrology / Issue 3/2020
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-018-4179-9

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