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International Urogynecology Journal

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01-12-2009 | Original Article

Urinary levels of glycosaminoglycans in patients with idiopathic detrusor overactivity

Authors: Salvatore Siracusano, Antonio Cucchi, Stefano Ciciliato, Nicolitza Lampropoulou, Franco Vittur

Published in: International Urogynecology Journal | Issue 12/2009

Abstract

Introduction and hypothesis

We assessed whether urinary excretion of glycosaminoglycans (GAGs) may be affected by a condition of detrusor overactivity (DO).

Materials and methods

We evaluated 24-h urinary excretion of GAGs in 25 patients (mean age 63.81 years) with DO and in 14 healthy controls (mean age 65.75 years). No patients or controls had urinary tract infection. The excretion of GAGs was measured on the basis of total urine volume and normalized to creatinine concentration. Student’s test was employed to check between the urinary excretion of GAGs in the two groups.

Results

The urinary content of GAGs discovered in control group was significantly higher than that in pathological group for the ratio GAGs/creatinine concentration.

Conclusions

The low content of GAGs might be due to relative ischemia of the bladder wall epithelial layer following a chronically increased contractile activity of the detrusor even if further studies are needed to confirm this finding.

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Title: Urinary levels of glycosaminoglycans in patients with idiopathic detrusor overactivity
Authors: Salvatore Siracusano
Antonio Cucchi
Stefano Ciciliato
Nicolitza Lampropoulou
Franco Vittur
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 12/2009
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-009-0973-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Urinary levels of glycosaminoglycans in patients with idiopathic detrusor overactivity

Abstract

Introduction and hypothesis

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Materials and methods

Results

Conclusions

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