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International Urogynecology Journal

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01-12-2009 | Original Article

Foreign body reaction in vaginally eroded and noneroded polypropylene suburethral slings in the female: a case series

Authors: Tilemachos Kavvadias, Daniel Kaemmer, Uwe Klinge, Stefanie Kuschel, Bernhard Schuessler

Published in: International Urogynecology Journal | Issue 12/2009

Abstract

Introduction and hypothesis

Aim of this study was to investigate the pattern of the foreign body reaction of macroporous polypropylene mesh (MPPM) used in females for the treatment of stress urinary incontinence and to compare this pattern between eroded and noneroded tapes.

Methods

Ten explanted suburethral slings, five eroded and five noneroded, were examined immunohistochemically under light microscopy; the tissue reaction was compared between eroded and noneroded materials.

Results

Eroded material showed a significantly higher accumulation of macrophages around the filaments of the mesh.

Conclusions

This is the first study comparing reaction around eroded and noneroded MPPMs and indicates a more intense tissue reaction around eroded mesh, when compared to noneroded material. More studies are needed to prove whether the detected foreign body reaction was the actual trigger for the erosion.

Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U et al (2003) The standardisation of terminology in lower urinary tract symptoms: report from the Standardisation Subcommittee of the International Continence Society. Urology 61:37–49CrossRefPubMed

Feifer A, Corcos J (2007) The use of synthetic suburethral slings in the treatment of female stress urinary incontinence. Int Urogynecol J 18:1087–1095CrossRef

Ward K, Hilton P, UK & Ireland TVT Trial Group (2008) Tension-free vaginal tape versus colposuspension for primary urodynamic stress incontinence: 5-year follow-up. BJOG 115:226–233CrossRefPubMed

Stanford E, Paraiso M (2008) A comprehensive review of suburethral sling procedure complications. J Minim Invasive Gynecol 15:132–145CrossRefPubMed

Weyhe D, Belyaev O, Buettner G, Mros K, Mueller C, Meurer K et al (2008) In vitro comparison of three different mesh constructions. ANZ J Surg 78:55–60PubMed

Klinge U, Si ZY, Zheng H, Schumpelick V, Bhardwaj R, Klosterhalfen B (2000) Abnormal collagen I to III distribution in the skin of patients with incisional hernia. Eur Surg Res 32:43–48CrossRefPubMed

Krambeck A, Dora C, Sebo T, Rohlinger A, DiMarco D, Elliott D (2006) Time-dependent variations in inflammation and scar formation of six different pubovaginal sling materials in the rabbit model. Urology 67:1105–1110CrossRefPubMed

Yildirim A, Basok E, Gulpinar T, Gurbuz C, Zemheri E, Tokuc R (2005) Tissue reaction of five sling materials and tissue detachment strength of four synthetic mesh materials in a rabbit model. J Urol 174:2037–2040CrossRefPubMed

Elmer C, Bo B, Falconer C, Zhang A, Altman D (2009) Histological inflammatory response to transvaginal polypropylene mesh for pelvic reconstructive surgery. J Urol 181:1189–1195CrossRefPubMed

10.

Woodruff A, Cole E, Dmochowski R, Scarpero H, Beckman E, Winters C (2008) Histologic comparison of pubovaginal sling graft materials: a comparative study. Urology 72:85–89CrossRefPubMed

11.

Meschia M, Pifaroti P, Bernasconi F, Magatti F, Vigano R, Bertozzi R et al (2007) Tension-free vaginal tape and intravaginal slingplasty for stress urinary incontinence: a multicenter randomised trial. Am J Obstet Gynecol 195:1338–1342

12.

Kuschel S, Schuessler B (2008) Results on function and safety of the Safyre-t, a hybrid transobturator vaginal sling for the treatment of stress urinary incontinence. Neurourol Urodyn 27:403–406CrossRefPubMed

13.

Boulanger L, Boukerrou M, Rubod C et al (2008) Bacteriological analysis of meshes removed for complications after surgical management of urinary incontinence or pelvic organ prolapse. Int Urogynecol J 19:827–831CrossRef

Title: Foreign body reaction in vaginally eroded and noneroded polypropylene suburethral slings in the female: a case series
Authors: Tilemachos Kavvadias
Daniel Kaemmer
Uwe Klinge
Stefanie Kuschel
Bernhard Schuessler
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 12/2009
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-009-0974-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Foreign body reaction in vaginally eroded and noneroded polypropylene suburethral slings in the female: a case series

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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