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01-03-2008 | Original Article

Urinary interleukin-6 is useful in distinguishing between upper and lower urinary tract infections

Authors: Luis Miguel Rodríguez, Belén Robles, José Manuel Marugán, Ángeles Suárez, Fernando Santos

Published in: Pediatric Nephrology | Issue 3/2008

Abstract

This study was designed to determine whether the measurement of interleukin (IL)-6 in urine is useful for distinguishing between acute pyelonephritis and lower urinary tract infection. This observational study was carried out at León Hospital (Spain) on 35 patients (ten boys) aged between 0 and 14 years with urinary tract infection. Urinary levels of IL-6 were determined with enzyme-linked immunosorbent assay (ELISA) at diagnosis and after recovery. Renal dimercaptosuccinate acid (DMSA) scan was performed on all patients to discard or confirm acute pyelonephritis. The mean urinary concentration [x ± standard deviation (SD)] of IL-6 at diagnosis was 20.3 ± 23.3 and 5.3 ± 9.7 pg/ml in patients with acute pyelonephritis and lower urinary infection, respectively [95% confidence interval (CI): 2.6–27.4; p < 0.01]. Specificity for a value of IL-6 >15 pg/ml, was 94.1% (95% CI: 91.1–97.1). Positive predictive value for IL-6 >15 pg/ml was 87.5% (95% CI: 81.1–93.8). IL-6 was undetectable in the urine of both groups of patients at the time of recovery. Urinary levels of IL-6 are useful in differentiating between upper and lower urinary tract infection in children. In this clinical setting, a value >15 pg/ml is a strong indicator of acute pyelonephritis.

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Title: Urinary interleukin-6 is useful in distinguishing between upper and lower urinary tract infections
Authors: Luis Miguel Rodríguez
Belén Robles
José Manuel Marugán
Ángeles Suárez
Fernando Santos
Publication date: 01-03-2008
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 3/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0670-4

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Urinary interleukin-6 is useful in distinguishing between upper and lower urinary tract infections

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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