Skip to main content
Top
Published in: European Archives of Oto-Rhino-Laryngology 1/2017

01-01-2017 | Rhinology

Upper airway structural changes induced by CPAP in OSAS patients: a study using drug-induced sleep endoscopy

Authors: Sung Hoon Jung, Soo Kweon Koo, Jang Won Choi, Ji Seung Moon, Sang Hoon Lee

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2017

Login to get access

Abstract

We studied upper airway structural changes induced by continuous positive airway pressure (CPAP) in obstructive sleep apnea syndrome (OSAS) patients using drug-induced sleep endoscopy (DISE). This prospective study was conducted at an academic secondary referral center. In total, 28 male OSAS patients (mean age 41.1 years) with only retropalatal level obstructions were enrolled. Measurements of the obstruction site were obtained in two steps: first a measurement was taken of the obstruction site in accordance with sleep apnea, then, a measurement was taken of the obstruction site in accordance with DISE-assisted CPAP titration, including quantitative changes in the occlusion site before and after CPAP in pixel format using an area calculation program. There was a tendency for persistent closing in cases of antero-posterior (AP) obstruction versus cases of lateral (Lat) obstruction in the CPAP titration. Lat obstructions showed a tendency to be wider than AP obstructions in the quantitative analysis. These results show that the pattern and degree of airway expansion after CPAP differ in accordance with the obstruction site.
Literature
1.
go back to reference Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230–1235CrossRefPubMed Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230–1235CrossRefPubMed
2.
3.
go back to reference Hertegonne K, Bauters F (2010) The value of auto-adjustable CPAP devices in pressure titration and treatment of patients. Sleep Med Rev 14:115–119CrossRefPubMed Hertegonne K, Bauters F (2010) The value of auto-adjustable CPAP devices in pressure titration and treatment of patients. Sleep Med Rev 14:115–119CrossRefPubMed
4.
go back to reference Schwab RJ, Pack AI, Gupta KB, Metzger LJ, Oh E, Getsy JE et al (1996) Upper airway and soft tissue structural changes induced by CPAP in normal subjects. Am J Respir Crit Care Med 154(4 Pt 1):1106–1116CrossRefPubMed Schwab RJ, Pack AI, Gupta KB, Metzger LJ, Oh E, Getsy JE et al (1996) Upper airway and soft tissue structural changes induced by CPAP in normal subjects. Am J Respir Crit Care Med 154(4 Pt 1):1106–1116CrossRefPubMed
5.
go back to reference Shepard JW Jr, Garrison M, Vas W (1990) Upper airway distensibility and collapsibility in patients with obstructive sleep apnea. Chest 98:84–91CrossRefPubMed Shepard JW Jr, Garrison M, Vas W (1990) Upper airway distensibility and collapsibility in patients with obstructive sleep apnea. Chest 98:84–91CrossRefPubMed
6.
go back to reference Stauffer JL, Zwillich CW, Cadieux RJ, Bixler EO, Kales A, Varano LA, White DP (1987) Pharyngeal size and resistance in obstructive sleep apnea. Am Rev Respir Dis 136:623–627CrossRefPubMed Stauffer JL, Zwillich CW, Cadieux RJ, Bixler EO, Kales A, Varano LA, White DP (1987) Pharyngeal size and resistance in obstructive sleep apnea. Am Rev Respir Dis 136:623–627CrossRefPubMed
7.
go back to reference Haponik EF, Smith PL, Bohlman ME, Allen RP, Goldman SM, Bleeker ER (1983) Computerized tomography in obstructive sleep apnea. Am Rev Respir Dis 127:221–226PubMed Haponik EF, Smith PL, Bohlman ME, Allen RP, Goldman SM, Bleeker ER (1983) Computerized tomography in obstructive sleep apnea. Am Rev Respir Dis 127:221–226PubMed
8.
go back to reference Croft CB, Pringle M (1991) Sleep nasendoscopy: a technique of assessment in snoring and obstructive sleep apnea. Clin Otolaryngol Allied Sci 16:504–509CrossRefPubMed Croft CB, Pringle M (1991) Sleep nasendoscopy: a technique of assessment in snoring and obstructive sleep apnea. Clin Otolaryngol Allied Sci 16:504–509CrossRefPubMed
9.
go back to reference Civelek S, Emre IE, Dizdar D, Cuhadaroglu C, Eksioglu BK, Eraslan AK et al (2012) Comparison of conventional continuous positive airway pressure to continuous positive airway pressure titration performed with sleep endoscopy. Laryngoscope 122(3):691–695CrossRefPubMed Civelek S, Emre IE, Dizdar D, Cuhadaroglu C, Eksioglu BK, Eraslan AK et al (2012) Comparison of conventional continuous positive airway pressure to continuous positive airway pressure titration performed with sleep endoscopy. Laryngoscope 122(3):691–695CrossRefPubMed
10.
go back to reference Hernandez-Gancedo C, Pestana D, Pena N, Royo C, Perez-Chrzanowska H, Criado A (2006) Monitoring sedation in critically ill patients: bispectral index, Ramsay and observer scales. Eur J Anaesthesiol 23:649–653CrossRefPubMed Hernandez-Gancedo C, Pestana D, Pena N, Royo C, Perez-Chrzanowska H, Criado A (2006) Monitoring sedation in critically ill patients: bispectral index, Ramsay and observer scales. Eur J Anaesthesiol 23:649–653CrossRefPubMed
11.
go back to reference Koo SK, Ahn GY, Choi JW, Kim YJ, Jung SH, Moon JS, Lee YI (2016) Obstructive sleep apnea in postmenopausal women: a comparative study using drug induced sleep endoscopy. Braz J Otorhinolaryngol. doi:10.1016/j.bjorl.2016.03.011 Koo SK, Ahn GY, Choi JW, Kim YJ, Jung SH, Moon JS, Lee YI (2016) Obstructive sleep apnea in postmenopausal women: a comparative study using drug induced sleep endoscopy. Braz J Otorhinolaryngol. doi:10.​1016/​j.​bjorl.​2016.​03.​011
12.
go back to reference Koo SK, Choi JW, Myung NS, Lee HJ, Kim YJ (2013) Analysis of obstruction site in obstructive sleep apnea syndrome patients by drug induced sleep endoscopy. Am J Otolaryngol 34:626–630CrossRefPubMed Koo SK, Choi JW, Myung NS, Lee HJ, Kim YJ (2013) Analysis of obstruction site in obstructive sleep apnea syndrome patients by drug induced sleep endoscopy. Am J Otolaryngol 34:626–630CrossRefPubMed
13.
go back to reference De Vito A, Carrasco Llatas M, Vanni A, Bosi M, Braghiroli A, Campanini A et al (2014) European position paper on drug-induced sedation endoscopy (DISE). Sleep Breath 18:453–465CrossRefPubMed De Vito A, Carrasco Llatas M, Vanni A, Bosi M, Braghiroli A, Campanini A et al (2014) European position paper on drug-induced sedation endoscopy (DISE). Sleep Breath 18:453–465CrossRefPubMed
14.
go back to reference Lopez-Campos JL, Garcia Polo C, Leon Jimenez A, Gonzalez-Moya E, Arnedillo A, Fernandez Berni JJ (2007) CPAP titration: different methods for similar clinical results. Eur J Intern Med 18:230–234CrossRefPubMed Lopez-Campos JL, Garcia Polo C, Leon Jimenez A, Gonzalez-Moya E, Arnedillo A, Fernandez Berni JJ (2007) CPAP titration: different methods for similar clinical results. Eur J Intern Med 18:230–234CrossRefPubMed
15.
go back to reference Masa JF (2004) Continuous positive airway pressure titration: manual, automatic, or empirical? Arch Bronconeumol 40(4):147–148CrossRefPubMed Masa JF (2004) Continuous positive airway pressure titration: manual, automatic, or empirical? Arch Bronconeumol 40(4):147–148CrossRefPubMed
16.
go back to reference Kuna ST, Bedi DG, Ryckman C (1988) Effect of nasal airway positive pressure on upper airway size and configuration. Am Rev Respir Dis 138:969–975CrossRefPubMed Kuna ST, Bedi DG, Ryckman C (1988) Effect of nasal airway positive pressure on upper airway size and configuration. Am Rev Respir Dis 138:969–975CrossRefPubMed
17.
go back to reference Ryan CF, Lowe AA, Li D, Fleetham JA (1991) Magnetic resonance imaging of the upper airway in obstructive sleep apnea before and after chronic nasal continuous positive airway pressure therapy. Am Rev Respir Dis 144:939–944CrossRefPubMed Ryan CF, Lowe AA, Li D, Fleetham JA (1991) Magnetic resonance imaging of the upper airway in obstructive sleep apnea before and after chronic nasal continuous positive airway pressure therapy. Am Rev Respir Dis 144:939–944CrossRefPubMed
18.
go back to reference Hoffstein V, Wright S, Zamel N, Bradley TD (1991) Pharyngeal function and snoring characteristics in apneic and nonapneic snorers. Am Rev Respir Dis 143:1294–1299CrossRefPubMed Hoffstein V, Wright S, Zamel N, Bradley TD (1991) Pharyngeal function and snoring characteristics in apneic and nonapneic snorers. Am Rev Respir Dis 143:1294–1299CrossRefPubMed
19.
go back to reference Rabelo FA, Braga A, Küpper DS, De Oliveira JA, Lopes FM, de Lima Mattos PL et al (2010) Propofol-induced sleep: polysomnographic evaluation of patients with obstructive sleep apnea and controls. Otolaryngol Head Neck Surg 142:218–224CrossRefPubMed Rabelo FA, Braga A, Küpper DS, De Oliveira JA, Lopes FM, de Lima Mattos PL et al (2010) Propofol-induced sleep: polysomnographic evaluation of patients with obstructive sleep apnea and controls. Otolaryngol Head Neck Surg 142:218–224CrossRefPubMed
20.
go back to reference Sadaoka T, Kakitsuba N, Fujiwara Y, Kanai R, Takahashi H (1996) The value of sleep nasendoscopy in the evaluation of patients with suspected sleep-related breathing disorders. Clin Otolaryngol Allied Sci 21:485–489CrossRefPubMed Sadaoka T, Kakitsuba N, Fujiwara Y, Kanai R, Takahashi H (1996) The value of sleep nasendoscopy in the evaluation of patients with suspected sleep-related breathing disorders. Clin Otolaryngol Allied Sci 21:485–489CrossRefPubMed
21.
go back to reference Hillman DR, Walsh JH, Maddison KJ, Platt PR, Kirkness JP, Noffsinger WJ et al (2009) Evolution of changes in the upper airway collapsibility during slow induction of anesthesia with propofol. Anesthesiology 111:63–71CrossRefPubMed Hillman DR, Walsh JH, Maddison KJ, Platt PR, Kirkness JP, Noffsinger WJ et al (2009) Evolution of changes in the upper airway collapsibility during slow induction of anesthesia with propofol. Anesthesiology 111:63–71CrossRefPubMed
22.
go back to reference Schwab RJ, Gupta KB, Gefter WB, Metzger LJ, Hoffman EA, Pack AI (1995) Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing. Significance of the lateral pharyngeal walls. Am J Respir Crit Care Med 152(5 Pt 1):1673–1689CrossRefPubMed Schwab RJ, Gupta KB, Gefter WB, Metzger LJ, Hoffman EA, Pack AI (1995) Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing. Significance of the lateral pharyngeal walls. Am J Respir Crit Care Med 152(5 Pt 1):1673–1689CrossRefPubMed
Metadata
Title
Upper airway structural changes induced by CPAP in OSAS patients: a study using drug-induced sleep endoscopy
Authors
Sung Hoon Jung
Soo Kweon Koo
Jang Won Choi
Ji Seung Moon
Sang Hoon Lee
Publication date
01-01-2017
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 1/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-4233-9

Other articles of this Issue 1/2017

European Archives of Oto-Rhino-Laryngology 1/2017 Go to the issue