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European Archives of Oto-Rhino-Laryngology

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01-01-2017 | Head and Neck

Overexpression of DCLK1 is predictive for recurrent disease in major salivary gland malignancies

Authors: Lorenz Kadletz, Klaus Aumayr, Gregor Heiduschka, Sven Schneider, Elisabeth Enzenhofer, Claudia Lill

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2017

Abstract

Salivary gland carcinomas are a rare malignancy. Therefore, little is known about biomarkers and cancer stem cells in salivary gland malignancies. Double cortin-like kinase 1 (DCLK1) is a promising therapeutic target and cancer stem cell marker, predominantly investigated in pancreatic and colorectal cancer. The purpose of this study was to investigate the expression of DCLK1 in major and minor salivary gland carcinomas and its influence on survival. We examined a total of 80 patients with major or minor salivary gland cancer in this retrospective study. Immunohistochemistry with anti-DCLK1 antibody was applied to assess the expression of DCLK1. Moreover, we evaluated the impact of DCLK1 on overall and disease-free survival. DCLK1 expression could be detected in 66.3 % of all examined cases. Overexpression of DCLK1 was associated with reduced overall and disease-free survival in patients with major salivary gland cancer. Disease-free survival reached statistical significance (p = 0.0107). However, expression of DCLK1 had no influence on survival in patients with minor salivary gland cancer. Since treatment of recurrent disease in oncologic patients is utterly challenging, DCLK1 may be a promising prognostic biomarker that helps to identify patients with a high risk for recurrence of major salivary gland carcinoma.

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Title: Overexpression of DCLK1 is predictive for recurrent disease in major salivary gland malignancies
Authors: Lorenz Kadletz
Klaus Aumayr
Gregor Heiduschka
Sven Schneider
Elisabeth Enzenhofer
Claudia Lill
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-4227-7

At a glance: The STEP trials

Springer Medicine

Overexpression of DCLK1 is predictive for recurrent disease in major salivary gland malignancies

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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