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Current Cardiology Reports
Published in: Current Cardiology Reports 8/2018

01-08-2018 | Cardio-Oncology (SA Francis and RB Morgan, Section Editors)

Update on Incorporating Biomarkers with Imaging Findings for the Detection and Management of Cardiotoxicity

Authors: Neha Quatromoni, Marielle Scherrer-Crosbie

Published in: Current Cardiology Reports | Issue 8/2018

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Abstract

Purpose of Review

Modern cancer therapy comes at a cost of increased risk of cardiotoxicity. The purpose of our paper is to provide an updated review highlighting research incorporating biomarkers and imaging findings for the detection of subclinical cardiac dysfunction and management of cancer treatment-related cardiotoxicity.

Recent Findings

Biomarkers, particularly troponin, NTproBNP, and myeloperoxidase, have been shown to have a predictive role in the development of cancer treatment-related cardiotoxicity. Early reductions in global longitudinal strain and the more recently reported, circumferential strain, have been shown to be predictive of subsequent cardiotoxicity. Integrating troponin levels with longitudinal strain may have incremental value in predicting future cardiotoxicity. Initiating troponin-guided heart failure therapy following cancer treatment may impact the development of cardiotoxicity. Strain-guided heart failure therapy is currently under investigation.

Summary

Early detection of subclinical cardiac dysfunction in high-risk cancer patients and subsequent medical intervention using biomarkers and imaging may help to alter the course of cancer treatment-induced cardiotoxicity. Current guidelines and expert consensus offer a general framework for monitoring high risk patients for cardiotoxicity. However, additional research is needed to provide a more sophisticated and structured approach in detecting and managing subclinical cardiac dysfunction with hopes of minimizing subsequent cardiotoxicity.
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Metadata
Title
Update on Incorporating Biomarkers with Imaging Findings for the Detection and Management of Cardiotoxicity
Authors
Neha Quatromoni
Marielle Scherrer-Crosbie
Publication date
01-08-2018
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 8/2018
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-018-1009-4

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