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Cardiovascular Drugs and Therapy
Published in: Cardiovascular Drugs and Therapy 1/2017

Open Access 01-02-2017 | REVIEW ARTICLE

Anthracycline Chemotherapy and Cardiotoxicity

Authors: John V McGowan, Robin Chung, Angshuman Maulik, Izabela Piotrowska, J Malcolm Walker, Derek M Yellon

Published in: Cardiovascular Drugs and Therapy | Issue 1/2017

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Abstract

Anthracycline chemotherapy maintains a prominent role in treating many forms of cancer. Cardiotoxic side effects limit their dosing and improved cancer outcomes expose the cancer survivor to increased cardiovascular morbidity and mortality. The basic mechanisms of cardiotoxicity may involve direct pathways for reactive oxygen species generation and topoisomerase 2 as well as other indirect pathways. Cardioprotective treatments are few and those that have been examined include renin angiotensin system blockade, beta blockers, or the iron chelator dexrazoxane. New treatments exploiting the ErbB or other novel pro-survival pathways, such as conditioning, are on the cardioprotection horizon. Even in the forthcoming era of targeted cancer therapies, the substantial proportion of today’s anthracycline-treated cancer patients may become tomorrow’s cardiac patient.
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Metadata
Title
Anthracycline Chemotherapy and Cardiotoxicity
Authors
John V McGowan
Robin Chung
Angshuman Maulik
Izabela Piotrowska
J Malcolm Walker
Derek M Yellon
Publication date
01-02-2017
Publisher
Springer US
Published in
Cardiovascular Drugs and Therapy / Issue 1/2017
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-016-6711-0

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