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Head and Neck Pathology
Published in: Head and Neck Pathology 1/2017

01-03-2017 | Original Paper

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

Authors: William H. Westra, James S. Lewis Jr.

Published in: Head and Neck Pathology | Issue 1/2017

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Abstract

The changes for oropharyngeal lesions in the 2017 edition of the WHO/IARC Classification of Head and Neck Tumours reference book are dramatic and significant, largely due to the growing impact of high risk human papillomavirus (HPV). The upcoming edition divides tumours of the oral cavity and oropharynx into separate chapters, classifies squamous cell carcinomas (SCC) of the oropharynx on the basis of HPV status, abandons the practice of histologic grading for oropharyngeal SCCs that are HPV positive, recognizes small cell carcinoma of the oropharynx, and combines polymorphous low grade adenocarcinoma and cribriform adenocarcinoma of tongue and minor salivary glands under the single term “polymorphous adenocarcinoma.” This review not only calls attention to these changes, but describes the rationale driving these changes and highlights their implications for routine clinical practice.
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Metadata
Title
Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx
Authors
William H. Westra
James S. Lewis Jr.
Publication date
01-03-2017
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2017
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-017-0793-2

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