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Head and Neck Pathology
Published in: Head and Neck Pathology 1/2009

Open Access 01-03-2009 | Proceedings of the 2009 Annual North American Society of Head and Neck Pathology Companion Meeting (Boston, MA)

The Changing Face of Head and Neck Cancer in the 21st Century: The Impact of HPV on the Epidemiology and Pathology of Oral Cancer

Author: William H. Westra

Published in: Head and Neck Pathology | Issue 1/2009

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Abstract

The longstanding notion that head and neck squamous cell carcinoma (HNSCC) is a uniform disease process is changing. Divergence in epidemiologic trends among HNSCCs arising in different anatomic subsites has introduced a view that HNSCC is a heterogeneous group. Analysis of molecular genetic changes discloses not just individual tumor differences, but also consistent large-scale differences that permit the recognition of important tumor subtypes. One recently recognized subtype is the human papillomavirus (HPV)-positive oropharyngeal carcinoma. HPV-positive oropharyngeal cancer now dominates the head and neck oncology landscape, and its escalating incidence is impacting on diagnostic, preventive and therapeutic practices.
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Metadata
Title
The Changing Face of Head and Neck Cancer in the 21st Century: The Impact of HPV on the Epidemiology and Pathology of Oral Cancer
Author
William H. Westra
Publication date
01-03-2009
Publisher
Humana Press Inc
Published in
Head and Neck Pathology / Issue 1/2009
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-009-0100-y

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