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Published in: BMC Pulmonary Medicine 1/2009

Open Access 01-12-2009 | Research article

Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosisstrain

Authors: Ana Isabel López-Calleja, Patricia Gavín, Ma Antonia Lezcano, Ma Asunción Vitoria, Ma José Iglesias, Joaquín Guimbao, Ma Ángeles Lázaro, Nalin Rastogi, Ma José Revillo, Carlos Martín, Sofia Samper

Published in: BMC Pulmonary Medicine | Issue 1/2009

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Abstract

Background

A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tuberculosis cases studied, was detected in a population-based molecular epidemiological study performed in Zaragoza (Spain) from 2001 to 2004.

Methods

The Mycobacterium tuberculosis drug-susceptible strain, named MTZ strain, was genetically characterized by IS6110-RFLP, Spoligotyping and by MIRU-VNTR typing and the genetic patterns obtained were compared with those included in international databases. The characteristics of the affected patients, in an attempt to understand why the MTZ strain was so highly transmitted among the population were also analyzed.

Results

The genetic profile of the MTZ strain was rare and not widely distributed in our area or elsewhere. The patients affected did not show any notable risk factor for TB.

Conclusion

The M. tuberculosis strain MTZ, might have particular transmissibility or virulence properties, and we believe that greater focus should be placed on stopping its widespread dissemination.
Appendix
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Metadata
Title
Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosisstrain
Authors
Ana Isabel López-Calleja
Patricia Gavín
Ma Antonia Lezcano
Ma Asunción Vitoria
Ma José Iglesias
Joaquín Guimbao
Ma Ángeles Lázaro
Nalin Rastogi
Ma José Revillo
Carlos Martín
Sofia Samper
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Pulmonary Medicine / Issue 1/2009
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/1471-2466-9-3

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Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.