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BMC Nephrology
Published in: BMC Nephrology 1/2014

Open Access 01-12-2014 | Research article

UMODpolymorphism rs12917707 is not associated with severe or stable IgA nephropathy in a large Caucasian cohort

Authors: Miriana Dinic, Lidia Ghisdal, Judith Racapé, Lise Thibaudin, Philippe Gatault, Marie Essig, Yann Le Meur, Christian Noël, Guy Touchard, Pierre Merville, Zineb Ajarchouh, Christophe Mariat, Marc Abramowicz, Daniel Abramowicz, Eric Alamartine

Published in: BMC Nephrology | Issue 1/2014

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Abstract

Background

Genetic factors are suspected in the pathogenesis of IgA nephropathy, as well as in the course of IgA nephropathy progression towards end stage renal failure. UMOD polymorphism rs12917707 is known to associate with end stage renal failure of mixed aetiologies.

Methods

We tested a large cohort of Caucasian patients for association of rs12917707 with IgA nephropathy showing a benign, stable course and with IgA nephropathy that progressed toward end stage renal failure.

Results

No association was observed between either groups, and a non-significant trend was observed for more severe IgA nephropathy with the allele reported to protect against end stage renal failure of mixed aetiologies.

Conclusion

We conclude that UMOD is unlikely to play a role in IgA nephropathy pathogenesis nor progression to end stage renal failure, and suggest that UMOD effects are restricted to some causes of renal disease, e.g. diabetes or hypertension.
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Metadata
Title
UMODpolymorphism rs12917707 is not associated with severe or stable IgA nephropathy in a large Caucasian cohort
Authors
Miriana Dinic
Lidia Ghisdal
Judith Racapé
Lise Thibaudin
Philippe Gatault
Marie Essig
Yann Le Meur
Christian Noël
Guy Touchard
Pierre Merville
Zineb Ajarchouh
Christophe Mariat
Marc Abramowicz
Daniel Abramowicz
Eric Alamartine
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2014
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/1471-2369-15-138

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