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International Journal of Colorectal Disease

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Open Access 01-12-2024 | Ulcerative Colitis | Research

The need for surgery in pediatric patients with inflammatory bowel disease treated with biologicals

Authors: Kaija-Leena Kolho, Anne Nikkonen, Laura Merras-Salmio, Pauliina Molander

Published in: International Journal of Colorectal Disease | Issue 1/2024

Abstract

Purpose

Inflammatory bowel disease (IBD) in childhood often presents with a more extensive and more aggressive disease course than adult-onset disease. We aimed to evaluate if biological treatment started in childhood decreases the need for intestinal surgery over time.

Methods

This was a retrospective, single-center, cohort study. All pediatric patients with IBD initiated to biological therapy at the Children’s Hospital, were included in the study and followed up to the first surgical procedure or re-operation in their adulthood or until 31.12.2021 when ≥ 18 of age. Data were collected from the pediatric registry of IBD patients with biologicals and medical charts.

Results

A total of 207 pediatric IBD patients were identified [150 with Crohn´s disease (CD), 31 with ulcerative colitis (UC), 26 with IBD unclassified (IBDU)] of which 32.9% (n = 68; CD 49, UC 13, IBDU 6) underwent intestinal surgery. At the end of a median follow-up of 9.0 years (range 2.0-25.9), patients reached a median age of 21.4 years (range 18–36). Patients who had intestinal surgery in childhood were more likely to have IBD-related surgery also in early adulthood. The duration of the disease at induction of the first biological treatment emerged as the only risk factor, with a longer duration in the surgical group than in patients with no surgery.

Conclusion

Despite initiation of biological treatment, the risk of intestinal surgery remains high in pediatric IBD patients and often the need for surgery emerges after the transition to adult IBD clinics.

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Title: The need for surgery in pediatric patients with inflammatory bowel disease treated with biologicals
Authors: Kaija-Leena Kolho
Anne Nikkonen
Laura Merras-Salmio
Pauliina Molander
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Ulcerative Colitis
Crohn's Disease
Chronic Inflammatory Bowel Disease
Infliximab
Published in: International Journal of Colorectal Disease / Issue 1/2024
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-024-04634-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The need for surgery in pediatric patients with inflammatory bowel disease treated with biologicals

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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