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Diabetologia
Published in: Diabetologia 10/2005

01-10-2005 | Commentary

Type 1 diabetes: treatment without tears?

Author: S. A. Amiel

Published in: Diabetologia | Issue 10/2005

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Excerpt

The tight relationship between intensified insulin therapy for type 1 diabetes and increased risk of severe hypoglycaemia is axiomatic. This assumption is repeated in paper after paper, usually quoting the DCCT, in which patients allocated randomly to the intensive therapy arm of the study showed a three-fold increase in severe hypoglycaemia [1]. But the DCCT, which demonstrated beyond doubt that improved glycaemic control reduced the risk of microvascular complications [2], reported its findings in 1993. It would be a sad reflection on the art and science of diabetes care if we had not moved forwards since then. …
Literature
1.
The DCCT Research Group (1991) Epidemiology of severe hypoglycemia in the Diabetes Control and Complications Trial. Am J Med 90:450–459
2.
The DCCT Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977–986
3.
Sämann A, Mühlhauser I, Bender R, Kloos C, Müller UA (2005) Glycaemic control and severe hypoglycaemia following training in flexible, intensive insulin therapy to enable dietary freedom in people with type 1 diabetes: a prospective implementation study. Diabetologia DOI 10.​1007/​s00125-005-1905-1
4.
Mühlhauser I, Jörgens V, Berger M et al (1983) Bicentric evaluation of a teaching and treatment programme for type 1 (insulin-dependent) diabetic patients: improvement of metabolic control and other measures of diabetes care for up to 22 months. Diabetologia 25:470–476PubMed
5.
Berger M, Cuppers HJ, Hegner H, Jorgens V, Berchtold P (1982) Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care 2:77–91
6.
Müller UA, Femerling M, Reinauer KM et al (1999) Intensified treatment and education of type 1 diabetes as clinical routine. A nationwide quality-circle experience in Germany. ASD (the Working Group on Structured Diabetes Therapy of the German Diabetes Association). Diabetes Care 22(Suppl 2):B29–B34PubMed
7.
Mühlhauser I, Bott U, Overmann H (1995) Liberalized diet in patients with type 1 diabetes. J Intern Med. 237:591–597PubMed
8.
Pieber TR, Brunner GA, Schnedl WJ, Schattenberg S, Kaufmann P, Krejs GJ (1995) Evaluation of a structured outpatient group education program for intensive insulin therapy. Diabetes Care 18:625–630PubMed
9.
DAFNE Study Group (2002) Training in flexible, intensive insulin management to enable dietary freedom in people with type 1 diabetes: dose adjustment for normal eating (DAFNE) randomised controlled trial. BMJ 325:746
10.
11.
Shearer A, Bagust A, Sanderson D, Heller S, Roberts S (2004) Effectiveness of flexible intensive insulin management to enable dietary freedom in people with type1 diabetes in the UK. Diabet Med 21:460–467CrossRefPubMed
Metadata
Title
Type 1 diabetes: treatment without tears?
Author
S. A. Amiel
Publication date
01-10-2005
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 10/2005
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-005-1923-z

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