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European Radiology

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01-02-2013 | Hepatobiliary-Pancreas

Two- versus three-dimensional dual gradient-echo MRI of the liver: a technical comparison

Authors: Michael A. Fischer, Olivio F. Donati, Natalie Chuck, Iris N. Blume, Roger Hunziker, Hatem Alkadhi, Daniel Nanz

Published in: European Radiology | Issue 2/2013

Abstract

Objective

To compare 2D spoiled dual gradient-echo (SPGR-DE) and 3D SPGR-DE with fat and water separation for the assessment of focal and diffuse fatty infiltration of the liver.

Methods

A total of 227 consecutive patients (141 men; 56 ± 14 years) underwent clinically indicated liver MRI at 1.5 T including multiple-breath-hold 2D SPGR-DE and single-breath-hold 3D SPGR-DE with automatic reconstruction of fat-only images. Two readers assessed the image quality and number of fat-containing liver lesions on 2D and 3D in- and opposed-phase (IP/OP) images. Liver fat content (LFC) was quantified in 138 patients without chronic liver disease from 2D, 3D IP/OP, and 3D fat-only images.

Results

Mean durations of 3D and 2D SPGR-DE acquisitions were 23.7 ± 2.9 and 97.2 ± 9.1 s respectively. The quality of all 2D and 3D images was rated diagnostically. Three-dimensional SPGR-DE revealed significantly more breathing artefacts resulting in lower image quality (P < 0.001); 2D and 3D IP/OP showed a similar detection rate of fat-containing lesions (P = 0.334) and similar LFC estimations (mean: +0.4 %; P = 0.048). LFC estimations based on 3D fat-only images showed significantly higher values (mean: 2.7 % + 3.5 %) than those from 2D and 3D IP/OP images (P < 0.001).

Conclusion

Three dimensional SPGR-DE performs as well as 2D SPGR-DE for the assessment of focal and diffuse fatty infiltration of liver parenchyma. The 3D SPGR-DE sequence used was quicker but more susceptible to breathing artefacts. Significantly higher LFC values are derived from 3D fat-only images than from 2D or 3D IP/OP images.

Key Points

• Magnetic resonance imaging can assess focal and diffuse hepatic fatty infiltration

• Both 2D and 3D dual-echo MRI techniques can be used for chemical shift imaging of the liver.

• The single breath-hold 3D dual-echo technique is faster but more susceptible to breathing artefacts.

• Three-dimensional fat-only images show higher fat estimates than in- and out-of-phase images.

Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C (2006) Prevalence of fatty liver in children and adolescents. Pediatrics 118:1388–1393PubMedCrossRef

Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ (2001) Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 21:17–26PubMedCrossRef

Clavien PA, Petrowsky H, DeOliveira ML, Graf R (2007) Strategies for safer liver surgery and partial liver transplantation. N Engl J Med 356:1545–1559PubMedCrossRef

Cassidy FH, Yokoo T, Aganovic L et al (2009) Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics 29:231–260PubMedCrossRef

Hines CD, Yu H, Shimakawa A et al (2010) Quantification of hepatic steatosis with 3-T MR imaging: validation in ob/ob mice. Radiology 254:119–128PubMedCrossRef

Raptis DA, Fischer MA, Graf R et al (2012) MRI: the new reference standard in quantifying hepatic steatosis? Gut 61:117–127PubMedCrossRef

d’Assignies G, Kauffmann C, Boulanger Y et al (2011) Simultaneous assessment of liver volume and whole liver fat content: a step towards one-stop shop preoperative MRI protocol. Eur Radiol 21:301–309PubMedCrossRef

d’Assignies G, Ruel M, Khiat A et al (2009) Noninvasive quantitation of human liver steatosis using magnetic resonance and bioassay methods. Eur Radiol 19:2033–2040PubMedCrossRef

Kim H, Taksali SE, Dufour S et al (2008) Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL. Magn Reson Med 59:521–527PubMedCrossRef

10.

Westphalen AC, Qayyum A, Yeh BM et al (2007) Liver fat: effect of hepatic iron deposition on evaluation with opposed-phase MR imaging. Radiology 242:450–455PubMedCrossRef

11.

Reeder SB, Cruite I, Hamilton G, Sirlin CB (2011) Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging 34:729–749PubMedCrossRef

12.

Hines CD, Frydrychowicz A, Hamilton G et al (2011) T(1) independent, T(2) (*) corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis. J Magn Reson Imaging 33:873–881PubMedCrossRef

13.

Kohgo Y, Ohtake T, Ikuta K, Suzuki Y, Torimoto Y, Kato J (2008) Dysregulation of systemic iron metabolism in alcoholic liver diseases. J Gastroenterol Hepatol 23(Suppl 1):S78–S81PubMedCrossRef

14.

Ma J, Vu AT, Son JB, Choi H, Hazle JD (2006) Fat-suppressed three-dimensional dual echo Dixon technique for contrast agent enhanced MRI. J Magn Reson Imaging 23:36–41PubMedCrossRef

15.

Ma J (2004) Breath-hold water and fat imaging using a dual-echo two-point Dixon technique with an efficient and robust phase-correction algorithm. Magn Reson Med 52:415–419PubMedCrossRef

16.

Mason D (2009) pydicom: a pure python package for working with DICOM files. http://pypi.python.org/pypi/pydicom/. Accessed 14.03.2011.

17.

Ringe KI, Husarik DB, Sirlin CB, Merkle EM (2010) Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver. AJR Am J Roentgenol 195:13–28PubMedCrossRef

18.

Rofsky NM, Lee VS, Laub G et al (1999) Abdominal MR imaging with a volumetric interpolated breath-hold examination. Radiology 212:876–884PubMed

19.

Springer F, Ehehalt S, Sommer J et al (2011) Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: a quantitative comparison with spectroscopic findings. Eur Radiol 21:816–822PubMedCrossRef

20.

Kim MJ, Mitchell DG, Ito K, Kim PN (2001) Hepatic MR imaging: comparison of 2D and 3D gradient echo techniques. Abdom Imaging 26:269–276PubMedCrossRef

21.

Marin D, Soher BJ, Dale BM, Boll DT, Youngblood RS, Merkle EM (2010) Characterization of adrenal lesions: comparison of 2D and 3D dual gradient-echo MR imaging at 3T–preliminary results. Radiology 254:179–187PubMedCrossRef

22.

Mitchell DG, Vinitski S, Saponaro S, Tasciyan T, Burk DL, Rifkin MD Jr (1991) Liver and pancreas: improved spin-echo T1 contrast by shorter echo time and fat suppression at 1.5 T. Radiology 178:67–71PubMed

23.

Cesbron-Metivier E, Roullier V, Boursier J et al (2010) Noninvasive liver steatosis quantification using MRI techniques combined with blood markers. Eur J Gastroenterol Hepatol 22:973–982PubMedCrossRef

24.

Fischer MA, Nanz D, Reiner CS et al (2010) Diagnostic performance and accuracy of 3-D spoiled gradient-dual-echo MRI with water- and fat-signal separation in liver-fat quantification: comparison to liver biopsy. Invest Radiol 45:465–470PubMedCrossRef

25.

McPherson S, Jonsson JR, Cowin GJ et al (2009) Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered. J Hepatol 51:389–397PubMedCrossRef

26.

Boll DT, Marin D, Redmon GM, Zink SI, Merkle EM (2010) Pilot study assessing differentiation of steatosis hepatis, hepatic iron overload, and combined disease using two-point dixon MRI at 3T: in vitro and in vivo results of a 2D decomposition technique. AJR Am J Roentgenol 194:964–971PubMedCrossRef

27.

Liu CY, McKenzie CA, Yu H, Brittain JH, Reeder SB (2007) Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise. Magn Reson Med 58:354–364PubMedCrossRef

28.

Meisamy S, Hines CD, Hamilton G et al (2011) Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy. Radiology 258:767–775PubMedCrossRef

Title: Two- versus three-dimensional dual gradient-echo MRI of the liver: a technical comparison
Authors: Michael A. Fischer
Olivio F. Donati
Natalie Chuck
Iris N. Blume
Roger Hunziker
Hatem Alkadhi
Daniel Nanz
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: European Radiology / Issue 2/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2614-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Two- versus three-dimensional dual gradient-echo MRI of the liver: a technical comparison

Abstract

Objective

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Key Points

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