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European Radiology

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01-02-2011 | Magnetic Resonance

Simultaneous assessment of liver volume and whole liver fat content: a step towards one-stop shop preoperative MRI protocol

Authors: Gaspard d’Assignies, Claude Kauffmann, Yvan Boulanger, Marc Bilodeau, Valérie Vilgrain, Gilles Soulez, An Tang

Published in: European Radiology | Issue 2/2011

Abstract

Objective

The purpose of this study was to evaluate the ability of a whole liver volume (WLV) segmentation algorithm to measure fat fraction (FF).

Methods

Twenty consecutive patients with histologically proven fatty liver disease underwent dual-echo in-phase/out-of-phase MRI and magnetic resonance spectroscopy (MRS) at 1.5 T. Two readers independently performed semiautomatic 3D liver segmentation on the out-of-phase sequences using an active contour model. FF was calculated for voxels, segments and WLV. Segmentation inter-observer reproducibility was assessed by intra-class correlation coefficient (ICC) for WLV and FF. Fat fraction correlation and agreement as determined by histology, MRS and MRI were determined.

Results

ICC was 0.999 (95% CI: 0.999-1, P < 0.001) for WLV FF calculation and 0.996 (95% CI: 0.990–0.998, P < 0.001) for whole liver volume calculations. Strong correlations were found between FF measured by histology, MRS and WLV-MRI. A Bland-Altman analysis showed a good agreement between FF measured by MRS and WLV-MRI. No systematic variations of FF was found between segments when analyzed by ANOVA (F = 1.78, P = 0.096).

Conclusion

This study shows that a reproducible whole liver volume segmentation method to measure fat fraction can be performed. This strategy may be integrated to a “one-stop shop” protocol in liver surgery planning.

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Title: Simultaneous assessment of liver volume and whole liver fat content: a step towards one-stop shop preoperative MRI protocol
Authors: Gaspard d’Assignies
Claude Kauffmann
Yvan Boulanger
Marc Bilodeau
Valérie Vilgrain
Gilles Soulez
An Tang
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: European Radiology / Issue 2/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1941-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Simultaneous assessment of liver volume and whole liver fat content: a step towards one-stop shop preoperative MRI protocol

Abstract

Objective

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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