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American Journal of Clinical Dermatology
Published in: American Journal of Clinical Dermatology 1/2020

01-02-2020 | Review Article

Twenty Clinically Pertinent Factors/Observations for Percutaneous Absorption in Humans

Authors: Rebecca M. Law, Mai A. Ngo, Howard I. Maibach

Published in: American Journal of Clinical Dermatology | Issue 1/2020

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Abstract

At least 20 clinically relevant factors affect percutaneous absorption of drugs and chemicals: relevant physico-chemical properties, vehicle/formulation, drug exposure conditions (dose, duration, surface area, exposure frequency), skin appendages (hair follicles, glands) as sub-anatomical pathways, skin application sites (regional variation in penetration), population variability (premature, infants, and aged), skin surface conditions (hydration, temperature, pH), skin health and integrity (trauma, skin diseases), substantivity and binding to different skin components, systemic distribution and systemic toxicity, stratum corneum exfoliation, washing-off and washing-in, rubbing/massaging, transfer to others (human to human and hard surface to human), volatility, metabolic biotransformation/cutaneous metabolism, photochemical transformation and photosensitivity, excretion pharmacokinetics, lateral spread, and chemical method of determining percutaneous absorption.
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Metadata
Title
Twenty Clinically Pertinent Factors/Observations for Percutaneous Absorption in Humans
Authors
Rebecca M. Law
Mai A. Ngo
Howard I. Maibach
Publication date
01-02-2020
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 1/2020
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-019-00480-4

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