Tumor necrosis factor alpha increases following sleep in young adults with type 1 diabetes

Excerpt

Poor glycemic control is associated with increased incidence of cardiovascular disease (CVD) in type 1 diabetes (T1DM). Disrupted sleep increases inflammation, a known contributor to CVD, in healthy individuals [1]. Young adults with T1DM have impaired sleep in comparison with healthy controls [2]. Degraded sleep architecture may contribute to chronic inflammation, ultimately increasing CVD risk. It is important to understand whether sleep plays a role in increased inflammation in individuals with T1DM as sleep is a potentially modifiable behavior. We hypothesized that sleep characteristics may mediate inflammation in young adults with T1DM. The aim was to define the relationships between sleep and the inflammatory markers interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in young adults with T1DM. …