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01-01-2019 | Clinical Study

Tubular brain tumor biopsy improves diagnostic yield for subcortical lesions

Authors: Evan D. Bander, Samuel H. Jones, David Pisapia, Rajiv Magge, Howard Fine, Theodore H. Schwartz, Rohan Ramakrishna

Published in: Journal of Neuro-Oncology | Issue 1/2019

Abstract

Purpose

Molecular data has become an essential part of the updated World Health Organization (WHO) grading of central nervous system tumors. However, stereotactic needle biopsies provide only small volume specimens and limit the extent of histologic and molecular testing that can be performed. We assessed the use of a tubular retractor-based minimally invasive biopsy technique to provide improved tissue yield and diagnostic data compared to needle biopsy.

Methods

Eighteen patients underwent an open transtubular biopsy compared to 146 stereotactic biopsies during the years of 2010–2018.

Results

Tubular biopsies resulted in a higher volume of tissue provided to the pathologist than needle biopsies (1.26 cm³ vs. 0.3 cm³; p < 0.0001). There was a higher rate of non-diagnostic sample with stereotactic compared to transtubular biopsy (13% vs. 0%; p = 0.13). Six patients who underwent stereotactic biopsy required reoperation for diagnosis, while no transtubular biopsy patient required reoperation in order to obtain a diagnostic specimen. Postoperative hematoma was the most common post-operative complication in both groups.

Conclusions

Stereotactic transtubular biopsies are a viable alternative to stereotactic needle biopsies with excellent rates of diagnostic success and acceptable morbidity relative to the needle biopsy technique. As molecular data begins to increasingly drive treatment decisions, additional biopsy techniques that afford large tissue volumes may be necessary to adapt to the new needs of pathologists and treating oncologists.

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Title: Tubular brain tumor biopsy improves diagnostic yield for subcortical lesions
Authors: Evan D. Bander
Samuel H. Jones
David Pisapia
Rajiv Magge
Howard Fine
Theodore H. Schwartz
Rohan Ramakrishna
Publication date: 01-01-2019
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 1/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-03014-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tubular brain tumor biopsy improves diagnostic yield for subcortical lesions

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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