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Journal of Neuro-Oncology

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01-01-2019 | Clinical Study

Brain T1ρ mapping for grading and IDH1 gene mutation detection of gliomas: a preliminary study

Authors: Mengqiu Cao, Weina Ding, Xu Han, Shiteng Suo, Yawen Sun, Yao Wang, Jianxun Qu, Xiaohua Zhang, Yan Zhou

Published in: Journal of Neuro-Oncology | Issue 1/2019

Abstract

Introduction

The longitudinal relaxation time in the rotating frame (T1ρ) has proved to be sensitive to metabolism and useful in application to neurodegenerative diseases. However, few literature exists on its utility in gliomas. Thus, this study was conducted to explore the performance of T1ρ mapping in tumor grading and characterization of isocitrate dehydrogenase 1 (IDH1) gene mutation status of gliomas.

Methods

Fifty-seven patients with gliomas underwent brain MRI and quantitative measurements of T1ρ and apparent diffusion coefficient (ADC) were recorded. Parameters were compared between high-grade gliomas (HGG) and low-grade gliomas (LGG) and between IDH1 mutant and wildtype groups.

Results

HGG showed significantly higher T1ρ values in both the solid and peritumoral edema areas compared with LGG (P < 0.001 and P = 0.005, respectively), whereas no significant differences in the two areas were found for ADC (both P > 0.05). Receiver operating characteristic (ROC) curve analysis showed that T1ρ value in the solid area achieved the highest area under the ROC curve (AUC, 0.841) in grading with a sensitivity of 80.6% and a specificity of 81.0%. In the grade II/III glioma group, multivariate logistic regression showed that both tumor frontal lobe location (odds ratio [OR] 526.608; P = 0.045) and T1ρ value of the peritumoral edema area (OR 0.863; P = 0.037) were significant predictors of IDH1 mutation. Using the combination, the diagnostic sensitivity and specificity for IDH1 mutated gliomas were 93.3% and 88.9%, respectively.

Conclusions

Our study shows the feasibility of applying T1ρ mapping in assessing the histologic grade and IDH1 mutation status of gliomas.

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Title: Brain T1ρ mapping for grading and IDH1 gene mutation detection of gliomas: a preliminary study
Authors: Mengqiu Cao
Weina Ding
Xu Han
Shiteng Suo
Yawen Sun
Yao Wang
Jianxun Qu
Xiaohua Zhang
Yan Zhou
Publication date: 01-01-2019
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 1/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-03033-7

At a glance: The STEP trials

Springer Medicine

Brain T1ρ mapping for grading and IDH1 gene mutation detection of gliomas: a preliminary study

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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