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Open Access 01-12-2024 | Tuberculosis | Research

Neutrophil lncRNA ZNF100-6:2 is a potential diagnostic marker for active pulmonary tuberculosis

Authors: Shuying Huang, Xiuhua Kang, Zhenguo Zeng, Qilong Zhang, Zikun Huang, Kaihang Luo, Qinqin Yao, Bing Chen, Cheng Qing

Published in: European Journal of Medical Research | Issue 1/2024

Abstract

Active pulmonary tuberculosis (PTB) poses challenges in rapid diagnosis within complex clinical conditions. Given the close association between neutrophils and tuberculosis, we explored differentially expressed long non-coding RNAs (lncRNAs) in neutrophils as potential molecular markers for diagnosing active PTB. We employed a gene microarray to screen for lncRNA alterations in neutrophil samples from three patients with active PTB and three healthy controls. The results revealed differential expression of 1457 lncRNAs between the two groups, with 916 lncRNAs upregulated and 541 lncRNAs down-regulated in tuberculosis patients. Subsequent validation tests demonstrated down-regulation of lncRNA ZNF100-6:2 in patients with active PTB, which was restored following anti-tuberculosis treatment. Our findings further indicated a high diagnostic potential for lncRNA ZNF100-6:2, as evidenced by an area under the receiver operating characteristic (ROC) curve of 0.9796 (95% confidence interval: 0.9479 to 1.000; P < 0.0001). This study proposes lncRNA ZNF100-6:2 as a promising and novel diagnostic biomarker for active PTB.

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Title: Neutrophil lncRNA ZNF100-6:2 is a potential diagnostic marker for active pulmonary tuberculosis
Authors: Shuying Huang
Xiuhua Kang
Zhenguo Zeng
Qilong Zhang
Zikun Huang
Kaihang Luo
Qinqin Yao
Bing Chen
Cheng Qing
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Tuberculosis
Tuberculosis
Mycobacterium Tuberculosis
Published in: European Journal of Medical Research / Issue 1/2024
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-024-01755-1

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Neutrophil lncRNA ZNF100-6:2 is a potential diagnostic marker for active pulmonary tuberculosis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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