Skip to main content
Top
Published in: BMC Infectious Diseases 1/2023

Open Access 01-12-2023 | Tuberculosis | Research

Influence of COVID-19 on the notification of drug-resistant pulmonary tuberculosis cases

Authors: Nathalia Halax Orfão, Rubia Laine de Paula Andrade, Antônio Ruffino-Netto, Leila Wiedmann Florentino da Silva, Tereza Cristina Scatena Villa, Marva Lynn Seifert, Adriana Zilly, Marcos Augusto Moraes Arcoverde, Ismael Hoare, Ricardo Izurieta, Reinaldo Antônio da Silva-Sobrinho

Published in: BMC Infectious Diseases | Issue 1/2023

Login to get access

Abstract

Background

To analyze the influence of the COVID-19 pandemic on the process of diagnosis and monitoring of drug-resistant pulmonary tuberculosis (TB) cases reported in the state of Paraná, Brazil, from 2015 to 2020.

Methods

Ecological study with quantitative approach. This study was based on diagnosed cases of pulmonary TB reported in the Notifiable Disease Information System in residents of Paraná; as well as through the number of confirmed cases of COVID-19 in the state epidemiological bulletin for the year 2020. The study data were analyzed using descriptive statistics.

Results

It was found that, although the number of reported pulmonary TB cases (drug-resistant and general) increased between 2015 and 2019, there was a drop in notification in 2020, the first year of the COVID-19 pandemic. The notification of TB cases was also influenced monthly during the year according to the increase in the number of COVID-19 cases. For cases of drug-resistant pulmonary TB, the provision of diagnostic tests and Directly Observed Treatment decreased by more than half in 2020, especially when compared to 2019.

Conclusions

In view of these findings, the influence of COVID-19 on the diagnosis and monitoring of drug-resistant and general pulmonary TB cases is evident, showing that the pandemic has compromised the advances of recent decades in achieving the goals established for its eradication by 2035.
Literature
1.
go back to reference World Health Organization (WHO). Global tuberculosis Report 2021. Geneva: WHO; 2021. World Health Organization (WHO). Global tuberculosis Report 2021. Geneva: WHO; 2021.
2.
go back to reference Kendall EA, Fofana MO, Dowdy DW. Carga da multirresistência transmitida em epidemias de tuberculose: uma análise de modelagem de transmissão. Lancet Respir Med. 2015;3(12):963–72.CrossRefPubMedPubMedCentral Kendall EA, Fofana MO, Dowdy DW. Carga da multirresistência transmitida em epidemias de tuberculose: uma análise de modelagem de transmissão. Lancet Respir Med. 2015;3(12):963–72.CrossRefPubMedPubMedCentral
3.
go back to reference Brasil. Ministério da Saúde. Manual de Recomendações para o Controle da tuberculose no Brasil. Brasília, 2019. Brasil. Ministério da Saúde. Manual de Recomendações para o Controle da tuberculose no Brasil. Brasília, 2019.
4.
go back to reference Bartholomay P, Pinheiro RS, Johansen FDC, Oliveira SB, Rocha MS, Pelissari DM, Araújo WN. Lacunas na vigilância da tuberculose drogarresistente: relacionando sistemas de informação do Brasil. Cad Saúde Pública. 2020;36(4):e00082219.CrossRefPubMed Bartholomay P, Pinheiro RS, Johansen FDC, Oliveira SB, Rocha MS, Pelissari DM, Araújo WN. Lacunas na vigilância da tuberculose drogarresistente: relacionando sistemas de informação do Brasil. Cad Saúde Pública. 2020;36(4):e00082219.CrossRefPubMed
5.
go back to reference Gniech AL, Gniech NR, Polese TR, D’Agostini FM, Fernandes LS. Tuberculose: perfil epidemiológico no estado de Santa Catarina, fatores de risco e resistência microbiana. Revista Multidisciplinar em Saúde. 2021;2(1):1. Gniech AL, Gniech NR, Polese TR, D’Agostini FM, Fernandes LS. Tuberculose: perfil epidemiológico no estado de Santa Catarina, fatores de risco e resistência microbiana. Revista Multidisciplinar em Saúde. 2021;2(1):1.
6.
go back to reference Villegas L, Otero L, Sterling TR, Huaman MA, Van der Stuyft P, Gotuzzo E, Seas C, Prevalence. Risk factors, and treatment outcomes of isoniazid- and rifampicin-mono-resistant pulmonary tuberculosis in Lima, Peru. PLoS ONE. 2016;11(4):e0152933.CrossRefPubMedPubMedCentral Villegas L, Otero L, Sterling TR, Huaman MA, Van der Stuyft P, Gotuzzo E, Seas C, Prevalence. Risk factors, and treatment outcomes of isoniazid- and rifampicin-mono-resistant pulmonary tuberculosis in Lima, Peru. PLoS ONE. 2016;11(4):e0152933.CrossRefPubMedPubMedCentral
7.
go back to reference Hogan AB, Jewell BL, Sherrard-Smith E, Vesga JF, Watson OJ, Whittaker C, et al. Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: a modelling study. The Lancet Global Health. 2020;8(9):e1132–41.CrossRefPubMedPubMedCentral Hogan AB, Jewell BL, Sherrard-Smith E, Vesga JF, Watson OJ, Whittaker C, et al. Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: a modelling study. The Lancet Global Health. 2020;8(9):e1132–41.CrossRefPubMedPubMedCentral
8.
go back to reference Vela-Ruiz JM, Ramos W, Cruz-Vargas JA. Cancer care challenges during COVID – 19 pandemic. Rev peru med exp salud publica. 2020;37(3):580–1.CrossRefPubMed Vela-Ruiz JM, Ramos W, Cruz-Vargas JA. Cancer care challenges during COVID – 19 pandemic. Rev peru med exp salud publica. 2020;37(3):580–1.CrossRefPubMed
9.
go back to reference Tullo JE, Lerea MJ, López P, Alonso L. Impact of COVID-19 on the provision of essential health services in Paraguay. Rev Panam Salud Publica. 2020;44:e161.CrossRefPubMedPubMedCentral Tullo JE, Lerea MJ, López P, Alonso L. Impact of COVID-19 on the provision of essential health services in Paraguay. Rev Panam Salud Publica. 2020;44:e161.CrossRefPubMedPubMedCentral
11.
go back to reference Maceira V, Vázquez G, Ariovich A, Crojethovic M, Jiménez C. Pandemia y desigualdad social: los barrios populares del conurbano bonaerense en el aislamiento social preventivo y obligatorio. Rev argent salud pública [online]. 2020;12(suppl1):12. Maceira V, Vázquez G, Ariovich A, Crojethovic M, Jiménez C. Pandemia y desigualdad social: los barrios populares del conurbano bonaerense en el aislamiento social preventivo y obligatorio. Rev argent salud pública [online]. 2020;12(suppl1):12.
12.
go back to reference Arroyo LH, Yamamura M, Ramos ACV, Campoy LT, Crispim JA, Berra TZ, Alves LS, Alves YM, Dos Santos FL, Souza LLL, Bruce ATI, de Andrade HLP, Bollela VR, Krainski ET, Nunes C, Arcêncio RA. Determinants of multidrug-resistant tuberculosis in São Paulo-Brazil: a multilevel bayesian analysis of factors associated with individual, community and access to health services. Trop Med Int Health. 2020 Jul;25(7):839–49. Arroyo LH, Yamamura M, Ramos ACV, Campoy LT, Crispim JA, Berra TZ, Alves LS, Alves YM, Dos Santos FL, Souza LLL, Bruce ATI, de Andrade HLP, Bollela VR, Krainski ET, Nunes C, Arcêncio RA. Determinants of multidrug-resistant tuberculosis in São Paulo-Brazil: a multilevel bayesian analysis of factors associated with individual, community and access to health services. Trop Med Int Health. 2020 Jul;25(7):839–49.
14.
go back to reference Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico. Brasília: Ministério da Saúde; 2020. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico. Brasília: Ministério da Saúde; 2020.
15.
go back to reference Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico. Brasília: Ministério da Saúde; 2021. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico. Brasília: Ministério da Saúde; 2021.
16.
go back to reference Magnabosco GT, Orfão NH, Brunello MEF, Wysoccki AD, Lopes LM, Campoy LT. Novas doenças e ameaças antigas: a repercussão da COVID-19 no manejo da tuberculose. Saúde Coletiva (Barueri). 2020;10(54):2639–44.CrossRef Magnabosco GT, Orfão NH, Brunello MEF, Wysoccki AD, Lopes LM, Campoy LT. Novas doenças e ameaças antigas: a repercussão da COVID-19 no manejo da tuberculose. Saúde Coletiva (Barueri). 2020;10(54):2639–44.CrossRef
17.
go back to reference Marwah V, Peter DK, Ajai Kumar T, Bhati G, Kumar A. Multidrug-resistant tuberculosis in COVID-19: double trouble. Med J Armed Forces India. 2021;77(Suppl 2):479–S482.CrossRef Marwah V, Peter DK, Ajai Kumar T, Bhati G, Kumar A. Multidrug-resistant tuberculosis in COVID-19: double trouble. Med J Armed Forces India. 2021;77(Suppl 2):479–S482.CrossRef
18.
go back to reference Santos FLd, Souza LLL, Bruce ATI, Crispim JdA, Arroyo LH, et al. Patients’ perceptions regarding multidrug-resistant tuberculosis and barriers to seeking care in a priority city in Brazil during COVID-19 pandemic: a qualitative study. PLoS ONE. 2021;16(4):e0249822.CrossRefPubMed Santos FLd, Souza LLL, Bruce ATI, Crispim JdA, Arroyo LH, et al. Patients’ perceptions regarding multidrug-resistant tuberculosis and barriers to seeking care in a priority city in Brazil during COVID-19 pandemic: a qualitative study. PLoS ONE. 2021;16(4):e0249822.CrossRefPubMed
19.
go back to reference Vilbrun SC, Mathurin L, Pape JW, Fitzgerald D, Walsh KF. Case Report: Multidrug-Resistant tuberculosis and COVID-19 coinfection in Port-au-Prince, Haiti. Am J Trop Med Hyg. 2020;103(5):1986–8.CrossRefPubMedPubMedCentral Vilbrun SC, Mathurin L, Pape JW, Fitzgerald D, Walsh KF. Case Report: Multidrug-Resistant tuberculosis and COVID-19 coinfection in Port-au-Prince, Haiti. Am J Trop Med Hyg. 2020;103(5):1986–8.CrossRefPubMedPubMedCentral
20.
21.
go back to reference Alene KA, Wangdi K, Clements ACA. Impact of the COVID-19 pandemic on Tuberculosis Control: an overview. Trop Med Infect Dis. 2020 Jul;24(3):123. Alene KA, Wangdi K, Clements ACA. Impact of the COVID-19 pandemic on Tuberculosis Control: an overview. Trop Med Infect Dis. 2020 Jul;24(3):123.
22.
go back to reference Brasil. Ministério da Saúde. Linha de cuidado da tuberculose: orientações para gestores e profissionais de saúde. Brasília, 2021. Brasil. Ministério da Saúde. Linha de cuidado da tuberculose: orientações para gestores e profissionais de saúde. Brasília, 2021.
23.
go back to reference Orfão NH, Ferreira MRL, de Souza GASC, Martins LM, Feitosa VG. COVID-19: estratégias de enfrentamento e comportamentos adaptativos pelos profissionais de saúde durante a pandemia. Volume 10. Revista de Epidemiologia e Controle de Infecção; 2020. 4. Orfão NH, Ferreira MRL, de Souza GASC, Martins LM, Feitosa VG. COVID-19: estratégias de enfrentamento e comportamentos adaptativos pelos profissionais de saúde durante a pandemia. Volume 10. Revista de Epidemiologia e Controle de Infecção; 2020. 4.
24.
go back to reference Saunders MJ, Evans CA. COVID-19, tuberculose e pobreza: evitando uma tempestade perfeita. Eur Respir J. 2020 julho;56(1):2001348. Saunders MJ, Evans CA. COVID-19, tuberculose e pobreza: evitando uma tempestade perfeita. Eur Respir J. 2020 julho;56(1):2001348.
25.
go back to reference Ballestero JGA, Garcia JM, Bollela VR, Ruffino-Netto A, Dalcolmo MMP, Moncaio ACS, Miguel NS, Rigolin IZ, Palha PF. Management of multidrug-resistant tuberculosis: main recommendations of the brazilian guidelines. J Bras Pneumol. 2020;46(2):e20190290.CrossRefPubMedPubMedCentral Ballestero JGA, Garcia JM, Bollela VR, Ruffino-Netto A, Dalcolmo MMP, Moncaio ACS, Miguel NS, Rigolin IZ, Palha PF. Management of multidrug-resistant tuberculosis: main recommendations of the brazilian guidelines. J Bras Pneumol. 2020;46(2):e20190290.CrossRefPubMedPubMedCentral
26.
go back to reference Soares VM, Almeida IN, Figueredo LJA, Haddad JPA, Oliveira CSF, Carvalho WDS, Miranda SS. Factors associated with tuberculosis and multidrug-resistant tuberculosis in patients treated at a tertiary referral hospital in the state of Minas Gerais, Brazil. J Bras Pneumol. 2020;46(2):e20180386.CrossRefPubMedPubMedCentral Soares VM, Almeida IN, Figueredo LJA, Haddad JPA, Oliveira CSF, Carvalho WDS, Miranda SS. Factors associated with tuberculosis and multidrug-resistant tuberculosis in patients treated at a tertiary referral hospital in the state of Minas Gerais, Brazil. J Bras Pneumol. 2020;46(2):e20180386.CrossRefPubMedPubMedCentral
27.
go back to reference Becerra MC, Huang CC, Lecca L, Bayona J, Contreras C, Calderon R, Yataco R, Galea J, Zhang Z, Atwood S, Cohen T, Mitnick CD, Farmer P, Murray M. Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study. BMJ. 2019;367:l5894.CrossRefPubMedPubMedCentral Becerra MC, Huang CC, Lecca L, Bayona J, Contreras C, Calderon R, Yataco R, Galea J, Zhang Z, Atwood S, Cohen T, Mitnick CD, Farmer P, Murray M. Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study. BMJ. 2019;367:l5894.CrossRefPubMedPubMedCentral
28.
go back to reference Chen MP, Miramontes R, Kammerer JS. Multidrug-resistant tuberculosis in the United States, 2011–2016: patient characteristics and risk factors. Int J Tuberc Lung Dis. 2020;24(1):92–9.CrossRefPubMed Chen MP, Miramontes R, Kammerer JS. Multidrug-resistant tuberculosis in the United States, 2011–2016: patient characteristics and risk factors. Int J Tuberc Lung Dis. 2020;24(1):92–9.CrossRefPubMed
29.
go back to reference Ndiaye M, Yanogo PK, Sawadogo B, Diallo F, Antara S, Meda N. Fatores associados à tuberculose multirresistente em Dacar, Senegal, 2010–2016. J Public Health Afr. 2020;10(2):1099.CrossRefPubMedPubMedCentral Ndiaye M, Yanogo PK, Sawadogo B, Diallo F, Antara S, Meda N. Fatores associados à tuberculose multirresistente em Dacar, Senegal, 2010–2016. J Public Health Afr. 2020;10(2):1099.CrossRefPubMedPubMedCentral
30.
go back to reference Jacobs MG, Pinto Junior VL. Caracterização da tuberculose drogarresistente no Brasil, 2014. Epidemiol Serv Saude. 2019;28(3):e2018294. Jacobs MG, Pinto Junior VL. Caracterização da tuberculose drogarresistente no Brasil, 2014. Epidemiol Serv Saude. 2019;28(3):e2018294.
32.
go back to reference Mohammed H, Oljira L, Roba KT, Yimer G, Fekadu A, Manyazewal T. Containment of COVID-19 in Ethiopia and implications for tuberculosis care and research. Infect Dis Poverty. 2020 Sep;16(1):131. Mohammed H, Oljira L, Roba KT, Yimer G, Fekadu A, Manyazewal T. Containment of COVID-19 in Ethiopia and implications for tuberculosis care and research. Infect Dis Poverty. 2020 Sep;16(1):131.
33.
go back to reference Visca D, Tiberi S, Pontali E, Spanevello A, Migliori GB. Tuberculosis in the time of COVID-19: quality of life and digital innovation. Eur Respir J. 2020 Aug;6(2):2001998. Visca D, Tiberi S, Pontali E, Spanevello A, Migliori GB. Tuberculosis in the time of COVID-19: quality of life and digital innovation. Eur Respir J. 2020 Aug;6(2):2001998.
Metadata
Title
Influence of COVID-19 on the notification of drug-resistant pulmonary tuberculosis cases
Authors
Nathalia Halax Orfão
Rubia Laine de Paula Andrade
Antônio Ruffino-Netto
Leila Wiedmann Florentino da Silva
Tereza Cristina Scatena Villa
Marva Lynn Seifert
Adriana Zilly
Marcos Augusto Moraes Arcoverde
Ismael Hoare
Ricardo Izurieta
Reinaldo Antônio da Silva-Sobrinho
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2023
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-023-08463-x

Other articles of this Issue 1/2023

BMC Infectious Diseases 1/2023 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine