Top

BMC Health Services Research

Published in:

01-12-2020 | Tuberculosis | Research article

Review of tuberculosis treatment outcome reporting system in Denmark, a retrospective study cohort study from 2009 through 2014

Authors: Inge K. Holden, Peter H. Andersen, Christian Wejse, Troels Lillebaek, Isik S. Johansen

Published in: BMC Health Services Research | Issue 1/2020

Abstract

Background

In Denmark, reporting of tuberculosis (TB) treatment outcome is voluntary and data incomplete. In the European Centre for Disease Prevention and Control most recent report presenting data from 2017, only 53.9% of Danish pulmonary TB cases had a reported outcome. Monitoring of TB treatment outcome is not feasible based on such limited results. In this retrospective study from 2009 to 2014, we present complete treatment outcome data and describe characteristics of cases lost to follow up.

Methods

All cases notified from 2009 through 2014 were reviewed. Hospital records were examined, and TB treatment outcome was categorized according to the World Health Organization’s (WHO) definitions.

Results

A total of 2131 TB cases were included. Treatment outcome was reported to the Surveillance Unit in 1803 (84.6%) cases, of which 468 (26.0%) were reclassified. For pulmonary TB, 339 (28.9%) cases were reclassified between cured and treatment completed.

Overall, the proportion of cases who achieved successful treatment outcome increased from 1488 (70.4%) to 1748 (81.8%).

Conclusion

A high number of cases were reclassified during the review process. Increased focus on correct treatment outcome reporting is necessary in Denmark. A more comprehensive and exhaustive categorization of TB treatment outcome could be beneficial, especially for cases where collection of sputum or tissue towards the end of treatment is challenging.

WHO Regional Office for Europe/European Centre for Disease Prevention and Control. Tuberculosis surveillance and monitoring in Europe 2019 – 2017 data. Copenhagen: WHO Regional Office for Europe; 2019.

Ditah IC, Reacher M, Palmer C, Watson JM, Innes J, Kruijshaar ME, et al. Monitoring tuberculosis treatment outcome: analysis of national surveillance data from a clinical perspective. Thorax. 2008;63(5):440–6.CrossRef

Dedicoat MJ, Gunther G, Crudu V, Duarte R, Gualano G, Magis-Escurra C, et al. Tuberculosis Treatment Outcomes in Europe: Based on Treatment Completion, Not Cure. Am J Respir Crit Care Med. 2017;196(9):1222–4.CrossRef

Holden IK, Lillebaek T, Seersholm N, Andersen PH, Wejse C, Johansen IS. Predictors for Pulmonary Tuberculosis Treatment Outcome in Denmark 2009-2014. Sci Rep. 2019;9(1):12995.CrossRef

World Health Organization. Definitions and reporting framework for tuberculosis – 2013 revision (updated December 2014). 2014.

Marx FM, Dunbar R, Enarson DA, Williams BG, Warren RM, van der Spuy GD, et al. The temporal dynamics of relapse and reinfection tuberculosis after successful treatment: a retrospective cohort study. Clin Infect Dis. 2014;58(12):1676–83.CrossRef

Luzze H, Johnson DF, Dickman K, Mayanja-Kizza H, Okwera A, Eisenach K, et al. Relapse more common than reinfection in recurrent tuberculosis 1-2 years post treatment in urban Uganda. Int J Tuberc Lung Dis. 2013;17(3):361–7.CrossRef

Antoine D, Che D. Treatment outcome monitoring of pulmonary tuberculosis cases notified in France in 2009. Euro Surveill. 2013;18(12).pii: 20434.

Baussano I, Pivetta E, Vizzini L, Abbona F, Bugiani M. Predicting tuberculosis treatment outcome in a low-incidence area. Int J Tuberc Lung Dis. 2008;12(12):1441–8.PubMed

10.

Diel R, Niemann S. Outcome of tuberculosis treatment in Hamburg: a survey, 1997-2001. Int J Tuberc Lung Dis. 2003;7(2):124–31.PubMed

11.

Holden IK, Lillebaek T, Andersen PH, Bjerrum S, Wejse C, Johansen IS. Extrapulmonary tuberculosis in Denmark from 2009 through 2014; characteristics and predictors for treatment outcome. Open Forum Infect Dis. 2019;6(10):ofz388. https://doi.org/10.1093/ofid/ofz388. eCollection 2019 Oct.

12.

Pascopella L, Barry PM, Flood J, DeRiemer K. Death with tuberculosis in california, 1994-2008. Open Forum Infect Dis. 2014;1(3):ofu090.CrossRef

13.

Borgdorff MW, Veen J, Kalisvaart NA, Nagelkerke N. Mortality among tuberculosis patients in The Netherlands in the period 1993-1995. Eur Respir J. 1998;11(4):816–20.CrossRef

14.

Caylà JACJ, Rey R, Lara N, Vallés X, Galdós-Tangüis H, Working Group on Completion of Tuberculosis Treatment in Spain. Current status of treatment completion and fatality among tuberculosis patients in Spain. Int J Tuberc Lung Dis. 2014;8(4):458–64.

15.

Kattan JA, Sosa LE, Lobato MN. Tuberculosis mortality: death from a curable disease, Connecticut, 2007-2009. Int J Tuberc Lung Dis. 2012;16(12):1657–62.CrossRef

16.

Sterling TR, Zhao Z, Khan A, Chaisson RE, Schluger N, Mangura B, et al. Mortality in a large tuberculosis treatment trial: modifiable and non-modifiable risk factors. Int J Tuberc Lung Dis. 2006;10(5):542–9.PubMed

17.

Day M, Middlemiss A, Thorpe J, Okereke E. What really happens to tuberculosis patients classified as lost to follow-up in West Yorkshire? Euro Surveill. 2012;17(38).pii: 20278.

18.

Thrane FD, Andersen PH, Johansen IS, Holden IK. Underreporting of patients diagnosed with tuberculosis in the Region of Southern Denmark. Scand J Public Health. 2019. https://doi.org/10.1177/1403494819884433.

Title: Review of tuberculosis treatment outcome reporting system in Denmark, a retrospective study cohort study from 2009 through 2014
Authors: Inge K. Holden
Peter H. Andersen
Christian Wejse
Troels Lillebaek
Isik S. Johansen
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Tuberculosis
Expectoration
Tuberculosis
Published in: BMC Health Services Research / Issue 1/2020
Electronic ISSN: 1472-6963
DOI: https://doi.org/10.1186/s12913-020-4927-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Review of tuberculosis treatment outcome reporting system in Denmark, a retrospective study cohort study from 2009 through 2014

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2020

The translation and psychometric assessment of the perception of empowerment in midwifery scale: the Persian version

The impact of accessibility and service quality on the frequency of patient visits to the primary diabetes care provider: results from a cross-sectional survey performed in six European countries

Identification of psychiatric patients with high mortality and low medical utilization: a population-based propensity score-matched analysis

Changes in health inequalities for patients with diabetes among middle-aged and elderly in China from 2011 to 2015

Persistence, adherence, healthcare resource utilisation and costs for interferon Beta in multiple sclerosis: a population-based study in the Campania region (southern Italy)

Association of Patient-Centered Medical Home designation and quality indicators within HRSA-funded community health center delivery sites