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01-01-2012 | Note

Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark

Authors: Weuller F. de Moraes, Pablinny Moreira Galdino, Marcus Vinícius M. Nascimento, Frederico Argollo Vanderlinde, Maria Teresa F. Bara, Elson A. Costa, José Realino de Paula

Published in: Journal of Natural Medicines | Issue 1/2012

Abstract

Bioassay-guided fractionation of the ethanolic extract of Pterodon emarginatus Vogel stem bark (EtEx) resulted in the isolation and characterization of lupeol and betulin. Their structures were elucidated by spectroscopic methods including IR, ¹H-NMR, ¹³C-NMR and comparison with literature values. This study showed the anti-inflammatory activity of EtEx, the hexane (HexL) and dichloromethane (DichL) layers, and lupeol and betulin. The extract, HexL, DichL, lupeol and betulin were able to inhibit acetic acid-induced writhing. In the formalin test, EtEx decreased licking time only in the second phase characterizing anti-inflammatory activity. In the oil-induced ear oedema test, EtEx, lupeol and betulin decrease edema formation. In conclusion, EtEx has antinociceptive effects arising from anti-inflammatory activity; this activity could be due to the presence of lupeol and betulin.

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Title: Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark
Authors: Weuller F. de Moraes
Pablinny Moreira Galdino
Marcus Vinícius M. Nascimento
Frederico Argollo Vanderlinde
Maria Teresa F. Bara
Elson A. Costa
José Realino de Paula
Publication date: 01-01-2012
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 1/2012
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-011-0547-5

2024 ASCO Annual Meeting

Springer Medicine

Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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