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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-04-2021 | Tremor | Research Article

Altered spontaneous brain activity in essential tremor with and without resting tremor: a resting-state fMRI study

Authors: Jun-ying Li, Xue-ling Suo, Nan-nan Li, Du Lei, Zhong-Jiao Lu, Ling Wang, Jia-xin Peng, Li-ren Duan, Jing-Xi, Yi-Jiang, Qi-yong Gong, Rong Peng

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 2/2021

Abstract

Objectives

Essential tremor with resting tremor (rET) often exhibits severer clinical features and more extensive functional impairment than essential tremor without resting tremor (ETwr). However, the pathophysiology of rET is still unclear. This study aims to use resting-state functional magnetic resonance imaging (rs-fMRI) to explore the alterations of brain activity between the drug-naïve patients of rET and ETwr.

Methods

We recruited 19 patients with rET, 31 patients with ETwr and 25 healthy controls (HCs) to undergo a 3.0-T rs-fMRI examination. The differences of regional brain spontaneous activity between the rET, ETwr and HCs, as well as between total ET (rET + ETwr) and HCs were measured by amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF). The relationships between the altered brain measurements and the clinical scores were analyzed.

Results

Compared with HCs, both ET subgroups showed significantly decreased ALFF or fALFF values in the basal ganglia, inferior orbitofrontal gyrus and insula. The rET group specifically showed decreased ALFF values in the hippocampus and motor cortices, while the ETwr group specifically evidenced increased ALFF and fALFF values in the cerebellum.

Discussion

Regional spontaneous activity in rET and ETwr share common changes and have differences, which may suggest that the functional activities in the limbic system and cerebellum are different between the two subtypes. Improved insights into rET and ETwr subtypes and the different brain spontaneous activity will be valuable for improving our understanding of the pathophysiology of the disease.

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Title: Altered spontaneous brain activity in essential tremor with and without resting tremor: a resting-state fMRI study
Authors: Jun-ying Li
Xue-ling Suo
Nan-nan Li
Du Lei
Zhong-Jiao Lu
Ling Wang
Jia-xin Peng
Li-ren Duan
Jing-Xi
Yi-Jiang
Qi-yong Gong
Rong Peng
Publication date: 01-04-2021
Publisher: Springer International Publishing
Keyword: Tremor
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 2/2021
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-020-00865-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Altered spontaneous brain activity in essential tremor with and without resting tremor: a resting-state fMRI study

Abstract

Objectives

Methods

Results

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Discussion

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