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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-04-2021 | Magnetic Resonance Imaging | Research Article

Sodium MRI of human articular cartilage of the wrist: a feasibility study on a clinical 3T MRI scanner

Authors: Anja Müller-Lutz, Benedikt Kamp, Armin M. Nagel, Alexandra Ljimani, Daniel Abrar, Christoph Schleich, Lena Wollschläger, Sven Nebelung, Hans-Jörg Wittsack

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 2/2021

Abstract

Objective

To measure sodium relaxation times and concentrations in human wrists on a clinical magnetic resonance imaging (MRI) scanner with a density-adapted radial sequence.

Materials and methods

Sodium MRI of human wrists was conducted on a 3T MR system using a dual-tuned ¹H/²³Na surface coil. We performed two studies with 10 volunteers each investigating either sodium T₁ (study 1) or sodium T₂* (study 2) relaxation times in the radiocarpal joint (RCJ) and midcarpal joint (MCJ). Sodium concentrations of both regions were determined.

Results

No differences for transversal of longitudinal relaxation times were found between RCJ and MCJ (T_2,s*(RCJ) = (0.9 ± 0.4) ms; T_2,s*(MCJ) = (0.9 ± 0.3) ms; T_2,l*(RCJ) = (14.9 ± 0.9) ms; T_2,l*(MCJ) = (13.9 ± 1.1) ms; T₁(RCJ) = (19.0 ± 2.4) ms; T₁(MCJ) = (18.5 ± 2.1) ms). Sodium concentrations were (157.7 ± 28.4) mmol/l for study 1 and (159.8 ± 29.1) mmol/l for study 2 in the RCJ, and (172.7 ± 35.6) mmol/l for study 1 and (163.4 ± 26.3) mmol/l for study 2 in the MCJ.

Conclusion

We successfully determined sodium relaxation times and concentrations of the human wrist on a 3T MRI scanner.

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Title: Sodium MRI of human articular cartilage of the wrist: a feasibility study on a clinical 3T MRI scanner
Authors: Anja Müller-Lutz
Benedikt Kamp
Armin M. Nagel
Alexandra Ljimani
Daniel Abrar
Christoph Schleich
Lena Wollschläger
Sven Nebelung
Hans-Jörg Wittsack
Publication date: 01-04-2021
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 2/2021
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-020-00856-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sodium MRI of human articular cartilage of the wrist: a feasibility study on a clinical 3T MRI scanner

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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