Published in:
01-06-2017 | Images in CV Applications
Transthyretin cardiac amyloid and aortic stenosis in the elderly, the role of nuclear imaging
Authors:
Elisa Merli, Eleonora Del Giudice, Athanassios Antonopoulos, Gianadrea Amadei, Elisabetta Varani
Published in:
The International Journal of Cardiovascular Imaging
|
Issue 6/2017
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Excerpt
Cardiac amyloidosis is an under recognised cause of heart failure in the elderly [
1]. It is predominantly related to myocardial deposition of wild-type transthyretin protein (aTTR) causing a restrictive cardiomyopathy and it is associated with poor prognosis [
2]. Radionuclide bone scan is able to detect transthyretin myocardial deposition. Moderate and intense captation by the myocardium has been demonstrated diagnostic without need of myocardial biopsy [
3]. This tool has given us the possibility to expand the diagnosis of transthyretin cardiac amyloidosis. Data from post-mortem studies in unselected subjects indicate a prevalence of cardiac amyloidosis of 22–25% in subjects older than 80 years of age [
4]. …
