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01-03-2018 | Diagnostic Neuroradiology

Transit time corrected arterial spin labeling technique aids to overcome delayed transit time effect

Authors: Tae Jin Yun, Chul-Ho Sohn, Roh-Eul Yoo, Kyung Mi Kang, Seung Hong Choi, Ji-hoon Kim, Sun-Won Park, Moonjung Hwang, R. Marc Lebel

Published in: Neuroradiology | Issue 3/2018

Abstract

Purpose

This study aimed to evaluate the usefulness of transit time corrected cerebral blood flow (CBF) maps based on multi-phase arterial spin labeling MR perfusion imaging (ASL-MRP).

Methods

The Institutional Review Board of our hospital approved this retrospective study. Written informed consent was waived. Conventional and multi-phase ASL-MRPs and dynamic susceptibility contrast MR perfusion imaging (DSC-MRP) were acquired for 108 consecutive patients. Vascular territory-based volumes of interest were applied to CBF and time to peak (TTP) maps obtained from DSC-MRP and CBF maps obtained from conventional and multi-phase ASL-MRPs. The concordances between normalized CBF (nCBF) from DSC-MRP and nCBF from conventional and transition time corrected CBF maps from multi-phase ASL-MRP were evaluated using Bland-Altman analysis. In addition, the dependence of difference between nCBF (ΔnCBF) values obtained from DSC-MRP and conventional ASL-MRP (or multi-phase ASL-MRP) on TTP obtained from DSC-MRP was also analyzed using regression analysis.

Results

The values of nCBFs from conventional and multi-phase ASL-MRPs had lower values than nCBF based on DSC-MRP (mean differences, 0.08 and 0.07, respectively). The values of ΔnCBF were dependent on TTP values from conventional ASL-MRP technique (F = 5.5679, P = 0.0384). No dependency of ΔnCBF on TTP values from multi-phase ASL-MRP technique was revealed (F = 0.1433, P > 0.05).

Conclusion

The use of transit time corrected CBF maps based on multi-phase ASL-MRP technique can overcome the effect of delayed transit time on perfusion maps based on conventional ASL-MRP.

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Title: Transit time corrected arterial spin labeling technique aids to overcome delayed transit time effect
Authors: Tae Jin Yun
Chul-Ho Sohn
Roh-Eul Yoo
Kyung Mi Kang
Seung Hong Choi
Ji-hoon Kim
Sun-Won Park
Moonjung Hwang
R. Marc Lebel
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 3/2018
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-017-1969-x

At a glance: The STEP trials

Springer Medicine

Transit time corrected arterial spin labeling technique aids to overcome delayed transit time effect

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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