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Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 1/2024

Open Access 01-12-2024 | Tranexamic Acid | Original research

Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis

Authors: Jia-Xing Song, Jian-Xiang Wu, Hai Zhong, Wei Chen, Jian-Chun Zheng

Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | Issue 1/2024

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Abstract

Objective

Tranexamic acid (TXA) demonstrates therapeutic efficacy in the management of traumatic brain injury (TBI). The objective of this systematic review and meta-analysis was to evaluate the safety and effectiveness of TXA in patients with TBI.

Methods

The databases, namely PubMed, Embase, Web of Science, and Cochrane Library databases, were systematically searched to retrieve randomized controlled trials (RCTs) investigating the efficacy of TXA for TBI from January 2000 to November 2023.

Results

The present meta-analysis incorporates ten RCTs. Compared to the placebo group, administration of TXA in patients with TBI resulted in a significant reduction in mortality (P = 0.05), hemorrhage growth (P = 0.03), and volume of hemorrhage growth (P = 0.003). However, no significant impact was observed on neurosurgery outcomes (P = 0.25), seizure occurrence (P = 0.78), or pulmonary embolism incidence (P = 0.52).

Conclusion

The administration of TXA is significantly associated with reduced mortality and hemorrhage growth in patients suffering from TBI, while the need of neurosurgery, seizures, and incidence of pulmonary embolism remains comparable to that observed with placebo.
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Metadata
Title
Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis
Authors
Jia-Xing Song
Jian-Xiang Wu
Hai Zhong
Wei Chen
Jian-Chun Zheng
Publication date
01-12-2024
Publisher
BioMed Central
DOI
https://doi.org/10.1186/s13049-024-01188-z

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