Skip to main content
Top
Published in: BMC Pulmonary Medicine 1/2019

Open Access 01-12-2019 | Tracheostomy | Research article

Impact of leaks and ventilation parameters on the efficacy of humidifiers during home ventilation for tracheostomized patients: a bench study

Authors: Noémie Haziot, Mohamed Ibrahim, Kaixian Zhu, Charles-Philippe Thevenin, Sebastien Hardy, Jésus Gonzalez-Bermejo

Published in: BMC Pulmonary Medicine | Issue 1/2019

Login to get access

Abstract

Background

During invasive ventilation, the upper airway is bypassed and no longer participates in humidification of inspired gases, which is essential to avoid harmful consequences such as endotracheal tube occlusion. In the case of increased air flow, especially in the presence of leaks (intentional or unintentional), the humidification provided by humidifiers may become ineffective. The objective of this bench study was to evaluate the quality of humidification provided by heated humidifiers under various home ventilation conditions.

Methods

Five heated humidifiers were tested in eight configurations combining circuit (expiratory valve or vented circuit), tidal volume (600 or 1000 mL) and presence of unintentional leak. Absolute humidity (AH) was measured at the upstream of the test lungs, which were placed in a 34 °C environmental chamber in order to simulate body temperature.

Results

The AH measured in the valve circuit ranged between 30 mg/L and 40 mg/L and three out of the five humidifiers achieved an AH higher than the recommended level (33 mg/L). With the vented circuit without unintentional leak, when tidal volume was set at 600 mL, all humidifiers reached an AH higher than 33 mg/L except one device; when the tidal volume was set at 1000 mL and unintentional leak was present, four out of the five humidifiers provided an AH lower than 33 mg/L.

Conclusion

This study shows that, except under certain home ventilation conditions, such as high tidal volumes with unintentional leak in vented circuit, most heated humidifiers ensure sufficient humidification to avoid the risk of side effect in patients.
Appendix
Available only for authorised users
Literature
1.
go back to reference Cerpa F, Cáceres D, Romero-Dapueto C, Giugliano-Jaramillo C, Pérez R, Budini H, et al. Humidification on ventilated patients: heated Humidifications or heat and moisture exchangers? Open Respir Med J. 2015;9:104–11.PubMedPubMedCentralCrossRef Cerpa F, Cáceres D, Romero-Dapueto C, Giugliano-Jaramillo C, Pérez R, Budini H, et al. Humidification on ventilated patients: heated Humidifications or heat and moisture exchangers? Open Respir Med J. 2015;9:104–11.PubMedPubMedCentralCrossRef
2.
go back to reference American Association for Respiratory Care. Restrepo RD, Walsh BK. Humidification during invasive and noninvasive mechanical ventilation: 2012. Respir Care. 2012 May;57(5):782–8.CrossRef American Association for Respiratory Care. Restrepo RD, Walsh BK. Humidification during invasive and noninvasive mechanical ventilation: 2012. Respir Care. 2012 May;57(5):782–8.CrossRef
3.
go back to reference Sortor Leger S. Upper airways humidification in patients using home mechanical ventilation. Rev Mal Respir. 2005 Dec;22(6 Pt 1):1065–70.PubMedCrossRef Sortor Leger S. Upper airways humidification in patients using home mechanical ventilation. Rev Mal Respir. 2005 Dec;22(6 Pt 1):1065–70.PubMedCrossRef
4.
go back to reference Roux NG, Plotnikow GA, Villalba DS, Gogniat E, Feld V, Ribero Vairo N, et al. Evaluation of an active humidification system for inspired gas. Clin Exp Otorhinolaryngol. 2015 Mar;8(1):69–75.PubMedPubMedCentralCrossRef Roux NG, Plotnikow GA, Villalba DS, Gogniat E, Feld V, Ribero Vairo N, et al. Evaluation of an active humidification system for inspired gas. Clin Exp Otorhinolaryngol. 2015 Mar;8(1):69–75.PubMedPubMedCentralCrossRef
6.
go back to reference McFadden ER, Pichurko BM, Bowman HF, Ingenito E, Burns S, Dowling N, et al. Thermal mapping of the airways in humans J Appl Physiol Bethesda Md 1985. 1985 Feb;58(2):564–70. McFadden ER, Pichurko BM, Bowman HF, Ingenito E, Burns S, Dowling N, et al. Thermal mapping of the airways in humans J Appl Physiol Bethesda Md 1985. 1985 Feb;58(2):564–70.
7.
go back to reference Chamney AR. Humidification requirements and techniques. Including a review of the performance of equipment in current use. Anaesthesia. 1969 Oct;24(4):602–17.PubMedCrossRef Chamney AR. Humidification requirements and techniques. Including a review of the performance of equipment in current use. Anaesthesia. 1969 Oct;24(4):602–17.PubMedCrossRef
8.
go back to reference Chalon J, Loew DA, Malebranche J. Effects of dry anesthetic gases on tracheobronchial ciliated epithelium. Anesthesiology. 1972 Sep;37(3):338–43.PubMedCrossRef Chalon J, Loew DA, Malebranche J. Effects of dry anesthetic gases on tracheobronchial ciliated epithelium. Anesthesiology. 1972 Sep;37(3):338–43.PubMedCrossRef
9.
go back to reference Chalon J, Patel C, Ali M, Ramanathan S, Capan L, Tang CK, et al. Humidity and the anesthetized patient. Anesthesiology. 1979 Mar;50(3):195–8.PubMedCrossRef Chalon J, Patel C, Ali M, Ramanathan S, Capan L, Tang CK, et al. Humidity and the anesthetized patient. Anesthesiology. 1979 Mar;50(3):195–8.PubMedCrossRef
10.
go back to reference Kilgour E, Rankin N, Ryan S, Pack R. Mucociliary function deteriorates in the clinical range of inspired air temperature and humidity. Intensive Care Med. 2004 Jul;30(7):1491–4.PubMedCrossRef Kilgour E, Rankin N, Ryan S, Pack R. Mucociliary function deteriorates in the clinical range of inspired air temperature and humidity. Intensive Care Med. 2004 Jul;30(7):1491–4.PubMedCrossRef
11.
go back to reference Shelly MP, Lloyd GM, Park GR. A review of the mechanisms and methods of humidification of inspired gases. Intensive Care Med. 1988;14(1):1–9.PubMedCrossRef Shelly MP, Lloyd GM, Park GR. A review of the mechanisms and methods of humidification of inspired gases. Intensive Care Med. 1988;14(1):1–9.PubMedCrossRef
12.
go back to reference Forbes AR. Humidification and mucous flow in the intubated trachea. Br J Anaesth. 1973 Jan;45(1):118.PubMed Forbes AR. Humidification and mucous flow in the intubated trachea. Br J Anaesth. 1973 Jan;45(1):118.PubMed
13.
go back to reference Solomita M, Smaldone GC. Humidification and noninvasive ventilation. Respir Care. 2007 Jan;52(1):24–5.PubMed Solomita M, Smaldone GC. Humidification and noninvasive ventilation. Respir Care. 2007 Jan;52(1):24–5.PubMed
14.
go back to reference Martin C, Perrin G, Gevaudan MJ, Saux P, Gouin F. Heat and moisture exchangers and vaporizing humidifiers in the intensive care unit. Chest. 1990 Jan;97(1):144–9.PubMedCrossRef Martin C, Perrin G, Gevaudan MJ, Saux P, Gouin F. Heat and moisture exchangers and vaporizing humidifiers in the intensive care unit. Chest. 1990 Jan;97(1):144–9.PubMedCrossRef
15.
go back to reference Villafane MC, Cinnella G, Lofaso F, Isabey D, Harf A, Lemaire F, et al. Gradual reduction of endotracheal tube diameter during mechanical ventilation via different humidification devices. Anesthesiology. 1996 Dec;85(6):1341–9.PubMedCrossRef Villafane MC, Cinnella G, Lofaso F, Isabey D, Harf A, Lemaire F, et al. Gradual reduction of endotracheal tube diameter during mechanical ventilation via different humidification devices. Anesthesiology. 1996 Dec;85(6):1341–9.PubMedCrossRef
16.
go back to reference Jaber S, Pigeot J, Fodil R, Maggiore S, Harf A, Isabey D, et al. Long-term effects of different humidification systems on endotracheal tube patency: evaluation by the acoustic reflection method. Anesthesiology. 2004 Apr;100(4):782–8.PubMedCrossRef Jaber S, Pigeot J, Fodil R, Maggiore S, Harf A, Isabey D, et al. Long-term effects of different humidification systems on endotracheal tube patency: evaluation by the acoustic reflection method. Anesthesiology. 2004 Apr;100(4):782–8.PubMedCrossRef
17.
go back to reference Kapadia FN. Factors associated with blocked tracheal tubes. Intensive Care Med. 2001 Oct;27(10):1679–81.PubMedCrossRef Kapadia FN. Factors associated with blocked tracheal tubes. Intensive Care Med. 2001 Oct;27(10):1679–81.PubMedCrossRef
18.
go back to reference American National Standards Institute, 1979. Z79.9 - Humidifiers and Nebulizers for Medical Use. ANSI, Washington American National Standards Institute, 1979. Z79.9 - Humidifiers and Nebulizers for Medical Use. ANSI, Washington
19.
go back to reference ISO 80601-2-74:2017 - Medical electrical equipment - Part 2–74: Particular requirements for basic safety and essential performance of respiratory humidifying equipment. ISO 80601-2-74:2017 - Medical electrical equipment - Part 2–74: Particular requirements for basic safety and essential performance of respiratory humidifying equipment.
20.
go back to reference Lellouche F, Taillé S, Maggiore SM, Qader S, L’her E, Deye N, et al. Influence of ambient and ventilator output temperatures on performance of heated-wire humidifiers. Am J Respir Crit Care Med. 2004 Nov 15;170(10):1073–9.PubMedCrossRef Lellouche F, Taillé S, Maggiore SM, Qader S, L’her E, Deye N, et al. Influence of ambient and ventilator output temperatures on performance of heated-wire humidifiers. Am J Respir Crit Care Med. 2004 Nov 15;170(10):1073–9.PubMedCrossRef
21.
go back to reference Nishida T, Nishimura M, Fujino Y, Mashimo T. Performance of heated humidifiers with a heated wire according to ventilatory settings. J Aerosol Med Off J Int Soc Aerosols Med. 2001;14(1):43–51.CrossRef Nishida T, Nishimura M, Fujino Y, Mashimo T. Performance of heated humidifiers with a heated wire according to ventilatory settings. J Aerosol Med Off J Int Soc Aerosols Med. 2001;14(1):43–51.CrossRef
22.
go back to reference Solomita M, Daroowalla F, Leblanc DS. Smaldone GC. Y-piece temperature and humidification during mechanical ventilation. Respir Care. 2009 Apr;54(4):480–6.PubMed Solomita M, Daroowalla F, Leblanc DS. Smaldone GC. Y-piece temperature and humidification during mechanical ventilation. Respir Care. 2009 Apr;54(4):480–6.PubMed
23.
go back to reference Wenzel M, Wenzel G, Klauke M, Kerl J, Hund-Rinke K. Characteristics of several humidifiers for CPAP-therapy, invasive and non-invasive ventilation and oxygen therapy under standardised climatic conditions in a climatic chamber. Pneumol Stuttg Ger. 2008 Jun;62(6):324–9.CrossRef Wenzel M, Wenzel G, Klauke M, Kerl J, Hund-Rinke K. Characteristics of several humidifiers for CPAP-therapy, invasive and non-invasive ventilation and oxygen therapy under standardised climatic conditions in a climatic chamber. Pneumol Stuttg Ger. 2008 Jun;62(6):324–9.CrossRef
24.
go back to reference Gilmour IJ, Boyle MJ, Rozenberg A, Palahniuk RJ. The effect of heated wire circuits on humidification of inspired gases. Anesth Analg. 1994 Jul;79(1):160–4.PubMedCrossRef Gilmour IJ, Boyle MJ, Rozenberg A, Palahniuk RJ. The effect of heated wire circuits on humidification of inspired gases. Anesth Analg. 1994 Jul;79(1):160–4.PubMedCrossRef
25.
go back to reference Lellouche F, Maggiore SM, Lyazidi A, Deye N, Taillé S, Brochard L. Water content of delivered gases during non-invasive ventilation in healthy subjects. Intensive Care Med. 2009 Jun;35(6):987–95.PubMedCrossRef Lellouche F, Maggiore SM, Lyazidi A, Deye N, Taillé S, Brochard L. Water content of delivered gases during non-invasive ventilation in healthy subjects. Intensive Care Med. 2009 Jun;35(6):987–95.PubMedCrossRef
26.
go back to reference Carter BG, Whittington N, Hochmann M, Osborne A. The effect of inlet gas temperatures on heated humidifier performance. J Aerosol Med Off J Int Soc Aerosols Med. 2002;15(1):7–13.CrossRef Carter BG, Whittington N, Hochmann M, Osborne A. The effect of inlet gas temperatures on heated humidifier performance. J Aerosol Med Off J Int Soc Aerosols Med. 2002;15(1):7–13.CrossRef
27.
go back to reference Oto J, Chenelle CT, Marchese AD, Kacmarek RM. A comparison of leak compensation in acute care ventilators during noninvasive and invasive ventilation: a lung model study. Respir Care. 2013 Dec 1;58(12):2027–37.PubMedCrossRef Oto J, Chenelle CT, Marchese AD, Kacmarek RM. A comparison of leak compensation in acute care ventilators during noninvasive and invasive ventilation: a lung model study. Respir Care. 2013 Dec 1;58(12):2027–37.PubMedCrossRef
28.
go back to reference Miyoshi E, Fujino Y, Uchiyama A, Mashimo T, Nishimura M. Effects of gas leak on triggering function, humidification, and inspiratory oxygen fraction during noninvasive positive airway pressure ventilation. Chest. 2005 Nov;128(5):3691–8.PubMedCrossRef Miyoshi E, Fujino Y, Uchiyama A, Mashimo T, Nishimura M. Effects of gas leak on triggering function, humidification, and inspiratory oxygen fraction during noninvasive positive airway pressure ventilation. Chest. 2005 Nov;128(5):3691–8.PubMedCrossRef
29.
go back to reference Holland AE, Denehy L, Buchan CA, Wilson JW. Efficacy of a heated passover humidifier during noninvasive ventilation: a bench study. Respir Care. 2007 Jan;52(1):38–44.PubMed Holland AE, Denehy L, Buchan CA, Wilson JW. Efficacy of a heated passover humidifier during noninvasive ventilation: a bench study. Respir Care. 2007 Jan;52(1):38–44.PubMed
30.
go back to reference Luján M, Sogo A, Grimau C, Pomares X, Blanch L, Monsó E. Influence of dynamic leaks in volume-targeted pressure support noninvasive ventilation: a bench study. Respir Care. 2015 Feb;60(2):191–200.PubMedCrossRef Luján M, Sogo A, Grimau C, Pomares X, Blanch L, Monsó E. Influence of dynamic leaks in volume-targeted pressure support noninvasive ventilation: a bench study. Respir Care. 2015 Feb;60(2):191–200.PubMedCrossRef
31.
go back to reference Prigent H, Samuel C, Louis B, Abinun M-F, Zerah-Lancner F, Lejaille M, et al. Comparative effects of two ventilatory modes on speech in tracheostomized patients with neuromuscular disease. Am J Respir Crit Care Med. 2003 Jan 15;167(2):114–9.PubMedCrossRef Prigent H, Samuel C, Louis B, Abinun M-F, Zerah-Lancner F, Lejaille M, et al. Comparative effects of two ventilatory modes on speech in tracheostomized patients with neuromuscular disease. Am J Respir Crit Care Med. 2003 Jan 15;167(2):114–9.PubMedCrossRef
32.
go back to reference Branson. Humidification for patients with artificial airways ricard Branson. Respir Care 1999;44(6):630–642. Branson. Humidification for patients with artificial airways ricard Branson. Respir Care 1999;44(6):630–642.
Metadata
Title
Impact of leaks and ventilation parameters on the efficacy of humidifiers during home ventilation for tracheostomized patients: a bench study
Authors
Noémie Haziot
Mohamed Ibrahim
Kaixian Zhu
Charles-Philippe Thevenin
Sebastien Hardy
Jésus Gonzalez-Bermejo
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Tracheostomy
Published in
BMC Pulmonary Medicine / Issue 1/2019
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/s12890-019-0812-z

Other articles of this Issue 1/2019

BMC Pulmonary Medicine 1/2019 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.