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BMC Pediatrics

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01-12-2021 | Toxoplasmosis | Research article

Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies

Authors: Jamila S. Al Malki, Nahed Ahmed Hussien, Fuad Al Malki

Published in: BMC Pediatrics | Issue 1/2021

Abstract

Background

Toxoplasmosis resulting from infection with the Toxoplasma parasite has become an endemic disease worldwide. Recently, a few studies have reported a high prevalence of Toxoplasmosis infections among Saudi Arabian women. This disease could become life threatening for pregnant women and for immunodeficient people. There is evidence that infections during pregnancy, especially in the early stages, are associated with neurodevelopmental disorders. Autism disorder represents one of the most common neurodevelopmental disorders worldwide; it is associated with delayed language development, weak communication interaction, and repetitive behavior. The relationship between prenatal toxoplasmosis and autism in childhood remains unclear. The present study aims to report a link between maternal toxoplasmosis and autistic offspring among Saudi Arabian women.

Method

Blood samples (36 maternal, 36 from their non-autistic children, and 36 from their autistic children) were collected for serological and molecular evaluation.

Results

A toxoplasmosis infection was reported for 33.34% of participants using an ELISA assay (5.56% IgG+/IgM+, 11.11% IgG−/IgM+, and 16.67% IgG+/IgM-); however, a nested PCR assay targeting B1 toxoplasmosis specific genes recorded positive tests for 80.56% of the samples. In addition, the present study detected several points of mutation of mtDNA including NADH dehydrogenase (ND1, ND4) and Cyt B genes and the nDNA pyruvate kinase (PK) gene for autistic children infected with toxoplasmosis.

Conclusion

Considering previous assumptions, we suggest that a maternal toxoplasmosis infection could have a role in the development of childhood autism linked to mtDNA and nDNA impairment.

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Title: Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies
Authors: Jamila S. Al Malki
Nahed Ahmed Hussien
Fuad Al Malki
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Toxoplasmosis
Published in: BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-021-02604-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies

Abstract

Background

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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