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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2004

01-04-2004 | Review

Towards in vivoapplication of RNA interference – new toys, old problems

Authors: Sascha Rutz, Alexander Scheffold

Published in: Arthritis Research & Therapy | Issue 2/2004

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Abstract

RNA interference (RNAi) is the sequence-specific degradation of mRNA by short double-stranded RNA molecules. The technology, introduced only 5 years ago, has stimulated many fantasies regarding the future of functional gene analysis and gene therapy. Given its ease of application, its high efficiency and remarkable specificity, RNAi holds great promise for broad in vitro and in vivo application in all areas of biomedicine. Despite its potential, the major obstacle to the use of RNAi (as for all previous gene silencing approaches) is the need for efficient and sustained delivery of small interfering RNA into primary mammalian cells, and specific targeting of particular cell types in vivo.
Appendix
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Metadata
Title
Towards in vivoapplication of RNA interference – new toys, old problems
Authors
Sascha Rutz
Alexander Scheffold
Publication date
01-04-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1168

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