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Journal of Thrombosis and Thrombolysis
Published in: Journal of Thrombosis and Thrombolysis 2/2013

01-02-2013 | Editorial

Toward a guided approach to platelet activation in diabetes

Author: M. D. Linden

Published in: Journal of Thrombosis and Thrombolysis | Issue 2/2013

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Excerpt

Diabetes is associated with substantially poorer cardiovascular outcomes. Furthermore, people with diabetes are at greatly increased risk of not responding to standard anti-platelet therapy for acute coronary syndromes, leading to higher mortality and stent thrombosis [1]. Poor glucose control likely contributes to these cardiovascular events through changes in platelet membrane fluidity and signalling, increased production of platelets leading to a greater fraction of younger and more reactive platelets not yet exposed to antiplatelet therapy, and increased triggering of platelet activation arising from an underlying thromboinflammatory milieu [2]. …
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Vivas D, Garcia-Rubira JC, Bernardo E, Angiolillo DJ, Martin P, Calle-Pascual A, Nunez-Gil I, Macaya C, Fernandez-Ortiz A (2011) Effects of intensive glucose control on platelet reactivity in patients with acute coronary syndromes. Results of the CHIPS Study (“Control de Hiperglucemia y Actividad Plaquetaria en Pacientes con Sindrome Coronario Agudo”). Heart 97(10):803–809PubMedCrossRef
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Linden MD, Furman MI, Frelinger AL 3rd, Fox ML, Barnard MR, Li Y, Przyklenk K, Michelson AD (2007) Indices of platelet activation and the stability of coronary artery disease. J Thromb Haemost 5(4):761–765PubMedCrossRef
Metadata
Title
Toward a guided approach to platelet activation in diabetes
Author
M. D. Linden
Publication date
01-02-2013
Publisher
Springer US
Published in
Journal of Thrombosis and Thrombolysis / Issue 2/2013
Print ISSN: 0929-5305
Electronic ISSN: 1573-742X
DOI
https://doi.org/10.1007/s11239-012-0852-1

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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