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Published in: Lung 4/2017

01-08-2017

Total IgM and Anti-Phosphatidylcholine IgM Antibody Secretion Continue After Clearance of Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection

Authors: Ciara Ordoñez, Musharaf Tarajia, René Rivera, Dilcia Sambrano, Victoria Batista, Mónica Chávez, Denis Tapia, Patricia L. Fernández, Amador Goodridge

Published in: Lung | Issue 4/2017

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Abstract

The cellular immune response to Mycobacterium tuberculosis infection has been well characterized, while the humoral antibody response remains underexplored. We aimed to examine the total and anti-phospholipid IgM levels in the pleural lavage from mice with Mycobacterium bovis BCG extrapulmonary infection. We found that the levels of total and anti-phosphatidylcholine IgM antibodies remained significantly higher in infected mice as compared to non-infected mice up to day 90 after BCG infection, while the anti-cardiolipin IgM antibody levels decreased with bacteria clearance. Our findings suggest that IgM antibodies are secreted and their composition vary during early and late immune response to BCG pleurisy.
Literature
1.
WHO (2016) The Global Tuberculosis Report 2015. Geneve, Switzerland
2.
3.
Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Inoue Y, Matsumoto M, McMurray DN, Dela Cruz EC, Tan EV, Abalos RM, Burgos JA, Saunderson P, Sakatani M (2009) Novel prophylactic and therapeutic vaccine against tuberculosis. Vaccine 27(25–26):3267–3270. doi:10.​1016/​j.​vaccine.​2009.​01.​064 CrossRefPubMed
4.
Kita Y, Okada M, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Nishimatsu S, Sekine Y, Takamori Y, McMurray DN, De la Cruz EC, Tan EV, Abalos RM, Burgos JA, Saunderson P, Sakatani M (2011) Development of therapeutic and prophylactic vaccine against Tuberculosis using monkey and transgenic mice models. Hum Vaccin 7(Suppl):108–114CrossRefPubMed
5.
Keicho N (2010) Biomarkers to assess different aspects of tuberculosis–from development to relapse. Kekkaku 85(11):823–828PubMed
6.
Fukui M, Shinjo K, Umemura M, Shigeno S, Harakuni T, Arakawa T, Matsuzaki G (2015) Enhanced effect of BCG vaccine against pulmonary Mycobacterium tuberculosis infection in mice with lung Th17 response to mycobacterial heparin-binding hemagglutinin adhesin antigen. Microbiol Immunol 59(12):735–743. doi:10.​1111/​1348-0421.​12340 CrossRefPubMed
7.
Ordway D, Palanisamy G, Henao-Tamayo M, Smith EE, Shanley C, Orme IM, Basaraba RJ (2007) The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig. J Immunol 179(4):2532–2541CrossRefPubMed
8.
Kahnert A, Hopken UE, Stein M, Bandermann S, Lipp M, Kaufmann SH (2007) Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs. J Infectious Dis 195(1):46–54. doi:10.​1086/​508894 CrossRef
9.
10.
Sato K, Shimizu T, Sano C, Tomioka H (2005) Effects of type II alveolar epithelial cells on T cell mitogenic responses to concanavalin A and purified protein derivatives. Microbiol Immunol 49(10):885–890CrossRefPubMed
11.
12.
13.
Momotani E, Kubo M, Ishikawa Y, Yoshino T (1989) Immunohistochemical localization of immunoglobulins in bovine granulomatous lesions. J Comp Pathol 100(2):129–136CrossRefPubMed
14.
Phuah JY, Mattila JT, Lin PL, Flynn JL (2012) Activated B cells in the granulomas of nonhuman primates infected with Mycobacterium tuberculosis. Am J Pathol 181(2):508–514CrossRefPubMedPubMedCentral
15.
Linge I, Dyatlov A, Kondratieva E, Avdienko V, Apt A, Kondratieva T (2017) B-lymphocytes forming follicle-like structures in the lung tissue of tuberculosis-infected mice: dynamics, phenotypes and functional activity. Tuberculosis 102:16–23. doi:10.​1016/​j.​tube.​2016.​11.​005 CrossRefPubMed
16.
Goodridge A, Zhang T, Miyata T, Lu S, Riley LW (2014) Antiphospholipid IgM antibody response in acute and chronic Mycobacterium tuberculosis mouse infection model. Clin Respir J 8(2):137–144. doi:10.​1111/​crj.​12049 CrossRefPubMed
17.
18.
Dunphy KY, Senaratne RH, Masuzawa M, Kendall LV, Riley LW (2010) Attenuation of Mycobacterium tuberculosis functionally disrupted in a fatty acyl-coenzyme A synthetase gene fadD5. J Infectious Dis 201(8):1232–1239CrossRef
19.
Sugawara I, Yamada H, Li C, Mizuno S, Takeuchi O, Akira S (2003) Mycobacterial infection in TLR2 and TLR6 knockout mice. Microbiol Immunol 47(5):327–336CrossRefPubMed
20.
Takatsu K, Kouro T, Nagai Y (2009) Interleukin 5 in the link between the innate and acquired immune response. Adv Immunol 101:191–236CrossRefPubMed
21.
Morosini M, Meloni F, Uccelli M, Marone Bianco A, Solari N, Fietta AM (2005) Ex vivo evaluation of PPD-specific IFN-gamma or IL-5 secreting cells in the peripheral blood and lungs of patients with tuberculosis. Int J Tuberc Lung Dis 9(7):753–759PubMed
22.
Somoskovi A, Zissel G, Zipfel PF, Ziegenhagen MW, Klaucke J, Haas H, Schlaak M, Muller-Quernheim J (1999) Different cytokine patterns correlate with the extension of disease in pulmonary tuberculosis. Eur Cytokine Netw 10(2):135–142PubMed
23.
Barnes PF, Lu S, Abrams JS, Wang E, Yamamura M, Modlin RL (1993) Cytokine production at the site of disease in human tuberculosis. Infect Immun 61(8):3482–3489PubMedPubMedCentral
24.
Romanowski B, Sutherland R, Fick GH, Mooney D, Love EJ (1991) Serologic response to treatment of infectious syphilis. Ann Intern Med 114(12):1005–1009CrossRefPubMed
25.
26.
27.
Jacobsen M, Mattow J, Repsilber D, Kaufmann SH (2008) Novel strategies to identify biomarkers in tuberculosis. Biol Chem 389(5):487–495CrossRefPubMed
Metadata
Title
Total IgM and Anti-Phosphatidylcholine IgM Antibody Secretion Continue After Clearance of Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection
Authors
Ciara Ordoñez
Musharaf Tarajia
René Rivera
Dilcia Sambrano
Victoria Batista
Mónica Chávez
Denis Tapia
Patricia L. Fernández
Amador Goodridge
Publication date
01-08-2017
Publisher
Springer US
Published in
Lung / Issue 4/2017
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-017-0019-0

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