3.7% of women under 40 globally suffer from primary ovarian insufficiency (POI), a condition previously known as premature or primary ovarian failure (POF) and marked by amenorrhea, elevated gonadotropins, and decreased estrogen levels [ 1 ]. The …

Primary ovarian insufficiency (POI) is defined by a decline in ovarian function leading to elevated gonadotropin levels and low estrogen levels in woman less than 40 years of age, accompanied by amenorrhea or infrequent menses [ 1 , 2 ••, 3 ]. POI …

Primary ovarian insufficiency (POI) is a common condition leading to the pathological decline of ovarian function in women of reproductive age, resulting in amenorrhea, hypogonadism, and infertility. Biochemical premature ovarian insufficiency …

Primary ovarian insufficiency (POI) is a hypoestrogenic endocrine disorder due to the premature cessation of ovarian function at < 40 years of age. The POI could be syndromic, as in Turner syndrome, due to genetic aberrations or iatrogenic …

Primary ovarian insufficiency (POI) is defined as primary or secondary amenorrhea with hypergonadotropic hypogonadism and hypoestrogenism prior to age 40, resulting from follicle dysfunction or follicle depletion. It can be observed either as an …

Recent advances in targeted therapy with monoclonal antibodies have significantly improved outcomes for people with cancer, sometimes allowing patients to avoid ovotoxic agents altogether. The current understanding is that monoclonal antibody …

Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is caused by 200 or more CGG repeats in the 5′ untranslated region of the FMR1 gene [ 1 ]. The fragile X premutation, characterized by 55–199 CGG repeats, occurs …

Premature activation of ovarian follicles leads to early depletion of the ovarian reserve, known as primary ovarian insufficiency (POI), a non-reversible pathology leading to female infertility [ 1 ]. POI is most commonly associated with X …

Over the last several decades, as women have delayed childbirth into their thirties, the diagnosis of primary ovarian insufficiency (POI) has increased. POI is defined as loss of ovarian follicles function with amenorrhea prior to the age of 40 [ 1 …]. A clinically heterogenous disorder, POI can be caused by infection, chronic disease, X-linked chromosomal abnormalities, and environment. Single gene defects are associated with > 10% of POI cases. More than forty genes (reviewed in [

Primary ovarian insufficiency (POI) is also known as premature menopause or premature ovarian failure and occurs when a woman’s ovaries are no longer working before 40 years of age. For women with POI, irregular menstruation and reduced fertility …

Premature or primary ovarian insufficiency (POI) affects approximately 1% of women and can be due to a variety of causes. Genetic causes include syndromic and non-syndromic POI. There are several promising candidate genes for whom a clear …

Human ovarian aging is related to the depletion of a preset primordial follicular pool that undergoes programmed cell death from conception until menopause [ 1 ]. A variety of factors affect this rate of follicular atresia, impacting a woman’s …

Primary ovarian insufficiency (POI) is a heterogeneous and multifactorial disorder characterized by absent menarche (primary amenorrhea) or cessation of menses for a period of at least 4–6 months (secondary amenorrhea), hypoestrogenism …