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5233 search results for:

Pharmacology and Toxicology 

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  1. Open Access 01-12-2024 | ReviewPaper

    Traditional uses, phytochemistry, pharmacology, quality control and clinical studies of Cimicifugae Rhizoma: a comprehensive review

    Cimicifugae Rhizoma, generally known as “Sheng Ma” in China, has great medicinal and dietary values. Cimicifugae Rhizoma is the dried rhizome of Cimicifuga foetida L., Cimicifuga dahurica (Turcz.) Maxim. and Cimicifuga heracleifolia Kom., which …

  2. 25-04-2024 | Erratum

    Correction: Uncovering the Mechanism of Chinese Hawthorn Leaf on Myocardial Ischemia Based on Network Pharmacology, Molecular Docking Verification, and In Vitro Studies

  3. Open Access 01-12-2024 | Mood Disorders | OriginalPaper

    Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach

    Major depressive disorder (MDD) is predicted to become the second most common cause of disability in the near future. Exposure to glyphosate (Gly)-based herbicides has been linked to the onset of MDD. However, the underlying mechanisms remain …

  4. Open Access 01-12-2024 | Liver Cirrhosis | OriginalPaper

    A novel network pharmacology strategy to decode mechanism of Wuling Powder in treating liver cirrhosis

    Liver cirrhosis is a chronic liver disease with hepatocyte necrosis and lesion. Liver ascites will appear when liver cirrhosis develops to the late stage. As of 2019, it was responsible for 2.4% of deaths worldwide [ 1 ]. Complex pathogenic …

  5. Oncology | Journal

    Cancer Chemotherapy and Pharmacology

    Cancer Chemotherapy and Pharmacology addresses a wide range of pharmacologic and oncologic concerns on both experimental and clinical levels. The primary focus of this rapid publication medium is on new anticancer agents, their experimental …

  6. Open Access 01-12-2023 | Pharmacokinetics | ReviewPaper

    Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics

    Psoralea corylifolia L. (PCL), referred to as “Bu-gu-zhi” in Chinese, has great medicinal values since ancient times. PCL is the dried ripe fruit of Psoralea corylifolia L., which has been widely used in traditional Chinese medicine (TCM) for the …

  7. 02-03-2024 | Checkpoint Inhibitors | ReviewPaper

    Utility and impact of quantitative pharmacology on dose selection and clinical development of immuno-oncology therapy

    Immuno-oncology (IO) therapies have changed the cancer treatment landscape. Immune checkpoint inhibitors (ICIs) have improved overall survival in 20–40% of patients with malignancies that were previously refractory. Due to the uniqueness in …

  8. 01-03-2024 | Addiction | Online First

    Understanding methiopropamine, a new psychoactive substance: an in-depth review on its chemistry, pharmacology and implications to human health

    Methiopropamine or 1-(thiophen-2-yl)-2-methylaminopropane (MPA) is a thiophene ring-based structural analogue of methamphetamine, first synthesized in 1942 but become popular when it started to be available for purchase on websites selling ‘legal …

  9. 16-12-2023 | Opioids | ReviewPaper

    Parenteral Meperidine: a Review of the Pharmacology and Clinical Applications

    Meperidine (1-methyl 4-phenyl-piperidine 4-carboxylic acid ethyl ester hydrochloride), commonly known by its trade name Demerol, was first synthesized by Eisleb and Shaumann in 1939 [ 1 ]. Meperidine’s opiate-like analgesic properties generated …

  10. 20-02-2024 | Active Ingredients | OriginalPaper

    Uncovering the Mechanism of Chinese Hawthorn Leaf on Myocardial Ischemia Based on Network Pharmacology, Molecular Docking Verification, and In Vitro Studies

    Hawthorn leaf has shown therapeutic effects in the patients with myocardial ischemia. Our study combines network pharmacology, molecular docking techniques, and in vitro experiment with the aim of revealing the mechanism of hawthorn leaves in the …

  11. Open Access 01-12-2022 | ReviewPaper

    Taxillus chinensis (DC.) Danser: a comprehensive review on botany, traditional uses, phytochemistry, pharmacology, and toxicology

    T. chinensis is predominantly found in East Asia, mainly in China, and belongs to the Loranthaceae species. T. chinensis is commonly found in some alpine and arid desert areas, mainly in southern and southwestern China, such as Guangxi, Fujian …

  12. 18-01-2023 | ReviewPaper

    Medicinal Effects, Phytochemistry, Pharmacology of Euphorbia prostrata and Promising Molecular Mechanisms

    Euphorbiaceae is a large family of dicotyledonous angiosperms with diverse genera including Euphorbia prostrata (E. prostrata). Current research has provided scientific evidence for traditional uses of E. prostrata against diverse pathological …

  13. 23-03-2022 | ReviewPaper

    Traditional Uses, Phytochemistry, Pharmacology and Toxicology of Rhizoma phragmitis: A Narrative Review

    Rhizoma phragmitis is a common Chinese herbal medicine whose effects are defined as ‘clearing heat and fire, promoting fluid production to quench thirst, eliminating irritability, stopping vomiting, and disinhibiting urine’. During the Novel …

  14. Open Access 01-12-2023 | ReviewPaper

    Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine

    Network pharmacology can ascertain the therapeutic mechanism of drugs for treating diseases at the level of biological targets and pathways. The effective mechanism study of traditional Chinese medicine (TCM) characterized by multi-component …

  15. 01-12-2020 | Pharmacokinetics

    Correction to: Review of traditional uses, botany, chemistry, pharmacology, pharmacokinetics, and toxicology of Radix Cyathulae

    In the original publication of this article [1], the English official name of the affiliation 1 has been changed to “Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China”.

  16. Open Access 01-12-2019 | Pharmacokinetics | ReviewPaper

    Review of traditional uses, botany, chemistry, pharmacology, pharmacokinetics, and toxicology of Radix Cyathulae

    Cyathulae Radix (CR), also known as “Chuanniux” is a well-known traditional Chinese herbal medicine that has been used in China for thousands of years. The present work reviewed advances in traditional uses, origin, chemical constituents …

  17. Open Access 15-07-2023 | Tianeptine | ReviewPaper

    Tianeptine, an Antidepressant with Opioid Agonist Effects: Pharmacology and Abuse Potential, a Narrative Review

    Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and …

  18. 16-06-2023 | Plague | ReviewPaper

    Clinical and Translational Pharmacology Considerations for Anti-infectives Approved Under the FDA Animal Rule

    The US Food and Drug Administration's Animal Rule provides a pathway for approval of drugs and biologics aimed to treat serious or life-threatening conditions wherein traditional clinical trials are either not ethical or feasible. In such a …

  19. 01-03-2021 | ReviewPaper

    Ethnopharmacology, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Radix Astragali

    Radix Astragali (RA), a traditional Chinese medicine from the dried root of Astragalus species, is widely distributed throughout the temperate regions of the world. The major bioactive constituents of RA are triterpene glycosides, flavonoids …

  20. Open Access 01-12-2022 | Active Ingredients | OriginalPaper

    Network toxicology and molecular docking analyses on strychnine indicate CHRM1 is a potential neurotoxic target

    ‘Maqianzi’ herb is used in Chinese folk medicine. It is used as a herbal remedy for rheumatism, musculoskeletal injuries and limb paralysis after processing to reduce its toxicity [ 1 ]. In addition, maqianzi exhibits excellent anti-tumor effect on …

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